Beneficial effects of ginger Zingiber officinale Roscoe on obesity and metabolic syndrome: a review

The Diagnosis and Management of Non-alcoholic Fatty Liver Disease: Practice Guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology

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Comparative antioxidant and anti-inflammatory effects of [6]-gingerol, [8]-gingerol, [10]-gingerol and [6]-shogaol

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Anti-diabetic and hypolipidaemic properties of ginger (Zingiber officinale) in streptozotocin-induced diabetic rats

Al-Amin, Z. M., Thomson, M., Al‐Qattan, K. K., Peltonen‐Shalaby, R., & Ali, M. (2006) · British Journal Of Nutrition · doi:10.1079/bjn20061849 · Cited by 420 · see citing works

Pharmacokinetics of 6-Gingerol, 8-Gingerol, 10-Gingerol, and 6-Shogaol and Conjugate Metabolites in Healthy Human Subjects

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Peroxisome Proliferator–Activated Receptors as Transcriptional Nodal Points and Therapeutic Targets

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Ginger Extract Consumption Reduces Plasma Cholesterol, Inhibits LDL Oxidation and Attenuates Development of Atherosclerosis in Atherosclerotic, Apolipoprotein E-Deficient Mice

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Effect of ethanolic extract of Zingiber officinale on dyslipidaemia in diabetic rats

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The effect of ginger consumption on glycemic status, lipid profile and some inflammatory markers in patients with type 2 diabetes mellitus

Arablou, T., Aryaeian, N., Valizadeh, M., Sharifi, F., Hosseini, A. F., & Djalali, M. (2014) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637486.2014.880671 · Cited by 228 · see citing works

Anti-diabetic activity of Zingiber officinale in streptozotocin-induced type I diabetic rats

Akhani, S. P., Vishwakarma, S., & Goyal, R. K. (2004) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357022403 · Cited by 222 · see citing works

Natural Dietary and Herbal Products in Anti-Obesity Treatment

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Deficiency of carbohydrate-activated transcription factor ChREBP prevents obesity and improves plasma glucose control in leptin-deficient ( ob/ob ) mice

Iizuka, K., Miller, B., & Uyeda, K. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00027.2006 · Cited by 195 · see citing works

Anti‐obesity action of gingerol: effect on lipid profile, insulin, leptin, amylase and lipase in male obese rats induced by a high‐fat diet

Saravanan, G., Ponmurugan, P., Deepa, M. A., & Senthilkumar, B. (2014) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.6642 · Cited by 161 · see citing works

Long-term biomedical and psychosocial outcomes following DAFNE (Dose Adjustment For Normal Eating) structured education to promote intensive insulin therapy in adults with sub-optimally controlled Type 1 diabetes

Speight, J., Amiel, S. A., Bradley, C., Heller, S., Oliver, L., Roberts, S., Rogers, H., Taylor, C., & Thompson, G. (2010) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2010.03.017 · Cited by 160 · see citing works

6-Shogaol and 6-gingerol, the pungent of ginger, inhibit TNF-α mediated downregulation of adiponectin expression via different mechanisms in 3T3-L1 adipocytes

Isa, Y., Miyakawa, Y., Yanagisawa, M., Goto, T., Kang, M., Kawada, T., Morimitsu, Y., Kubota, K., & Tsuda, T. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.06.046 · Cited by 156 · see citing works

The effect of ginger powder supplementation on insulin resistance and glycemic indices in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled trial

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Effects of ginger ( <i>Zingiber officinale</i> ) on plasma glucose level, HbA1c and insulin sensitivity in type 2 diabetic patients

Mahluji, S., Attari, V. E., Mobasseri, M., Payahoo, L., Ostadrahimi, A., & Golzari, S. E. (2013) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637486.2013.775223 · Cited by 153 · see citing works

Protective Effects of Ethanolic Extract of Zingiber officinale Rhizome on the Development of Metabolic Syndrome in High‐Fat Diet‐Fed Rats

Nammi, S., Satyanarayana, S., & Roufogalis, B. D. (2009) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2008.00362.x · Cited by 152 · see citing works

[6]-Gingerol isolated from ginger attenuates sodium arsenite induced oxidative stress and plays a corrective role in improving insulin signaling in mice

Chakraborty, D., Mukherjee, A., Sikdar, S., Paul, A., Ghosh, S., & Khuda‐Bukhsh, A. R. (2012) · Toxicology Letters · doi:10.1016/j.toxlet.2012.01.002 · Cited by 150 · see citing works

Ginger Essential Oil Ameliorates Hepatic Injury and Lipid Accumulation in High Fat Diet-Induced Nonalcoholic Fatty Liver Disease

Lai, Y.-S., Lee, W.-C., Lin, Y., Ho, C., Lu, K., Lin, S.-H., Panyod, S., Chu, Y., & Sheen, L. (2016) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5b06159 · Cited by 137 · see citing works

Effect of cinnamon, cardamom, saffron and ginger consumption on blood pressure and a marker of endothelial function in patients with type 2 diabetes mellitus: A randomized controlled clinical trial

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Inhibitory potential of ginger extracts against enzymes linked to type 2 diabetes, inflammation and induced oxidative stress

Rani, M. P., Padmakumari, K. P., Sankarikutty, B., Ozhathil, L. C., Nisha, V. M., & Raghu, K. G. (2010) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637486.2010.515565 · Cited by 135 · see citing works

Distinctive pharmacological differences between liver cancer cell lines HepG2 and Hep3B

Qiu, G., Xie, X., Xu, F., Shi, X., Wang, Y., & Deng, L. (2014) · Cytotechnology · doi:10.1007/s10616-014-9761-9 · Cited by 134 · see citing works

The effects of ginger on fasting blood sugar, hemoglobin a1c, apolipoprotein B, apolipoprotein a-I and malondialdehyde in type 2 diabetic patients.

Khandouzi, N., Shidfar, F., Rajab, A., Rahideh, S. T., Hosseini, P., & Taheri, M. M. (2015) · Europe PMC (PubMed Central) · Cited by 123 · see citing works

Ginger extract prevents high-fat diet-induced obesity in mice via activation of the peroxisome proliferator-activated receptor δ pathway

Misawa, K., Hashizume, K., Yamamoto, M., Minegishi, Y., Hase, T., & Shimotoyodome, A. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.04.014 · Cited by 123 · see citing works

Herbal or Natural Medicines as Modulators of Peroxisome Proliferator‐Activated Receptors and Related Nuclear Receptors for Therapy of Metabolic Syndrome

Huang, T. H.-W., Kota, B. P., Razmovski, V., & Roufogalis, B. D. (2005) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2005.pto960102.x · Cited by 121 · see citing works

Ameliorative potential of gingerol: Promising modulation of inflammatory factors and lipid marker enzymes expressions in HFD induced obesity in rats

Naidu, P. B., Uddandrao, V. V. S., Naik, R. R., Suresh, P., Meriga, B., Begum, M. S., Pandiyan, R., & Saravanan, G. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.10.007 · Cited by 116 · see citing works

Protective effect of dietary ginger on antioxidant enzymes and oxidative damage in experimental diabetic rat tissues

Shanmugam, K. R., Korivi, M., Nishanth, K., Kuo, C., & Reddy, K. S. (2010) · Food Chemistry · doi:10.1016/j.foodchem.2010.07.104 · Cited by 111 · see citing works

Beneficial effects of ginger ( Zingiber officinale ) on carbohydrate metabolism in streptozotocin-induced diabetic rats

Nafiu, B. A., Cho, M. M., Win, N. N., Zaman, R., & Rahman, M. T. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511006635 · Cited by 104 · see citing works

Mechanisms for antidiabetic effect of gingerol in cultured cells and obese diabetic model mice

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Effect of dietary supplementation of ginger and turmeric rhizomes on angiotensin-1 converting enzyme (ACE) and arginase activities in L-NAME induced hypertensive rats

Akinyemi, A. J., Thomé, G. R., Morsch, V. M., Stefanello, N., Goularte, J. F., Belló‐Klein, A., Oboh, G., & Schetinger, M. R. C. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.06.011 · Cited by 98 · see citing works

Ginger consumption enhances the thermic effect of food and promotes feelings of satiety without affecting metabolic and hormonal parameters in overweight men: A pilot study

Mansour, M. S., Ni, Y.-M., Roberts, A. L., Kelleman, M., RoyChoudhury, A., & St-Onge, M.-P. (2012) · Metabolism · doi:10.1016/j.metabol.2012.03.016 · Cited by 96 · see citing works

Ginger Supplementation in Nonalcoholic Fatty Liver Disease: A Randomized, Double-Blind, Placebo-Controlled Pilot Study

Rahimlou, M., Yari, Z., Hekmatdoost, A., Alavian, S. M., & Keshavarz, S. A. (2016) · Hepatitis Monthly · doi:10.5812/hepatmon.34897 · Cited by 93 · see citing works

6-Gingerol prevents adipogenesis and the accumulation of cytoplasmic lipid droplets in 3T3-L1 cells

Tzeng, T., & Liu, I.-M. (2013) · Phytomedicine · doi:10.1016/j.phymed.2012.12.006 · Cited by 90 · see citing works

Antihypercholesterolaemic effect of ginger rhizome (Zingiber officinale) in rats

ElRokh, E.-S. M., Yassin, N., El-Shenawy, S. M. A., & Ibrahim, B. M. M. (2010) · Inflammopharmacology · doi:10.1007/s10787-010-0053-5 · Cited by 87 · see citing works

Anti-Inflammatory Effects of Zingiber Officinale in Type 2 Diabetic Patients

Mahluji, S., Ostadrahimi, A., Mobasseri, M., Attari, V. E., & Payahoo, L. (2013) · Europe PMC (PubMed Central) · doi:10.5681/apb.2013.044 · Cited by 87 · see citing works

Changes of serum adipocytokines and body weight following Zingiber officinale supplementation in obese women: a RCT

Attari, V. E., Ostadrahimi, A., Jafarabadi, M. A., Sajjad, M., & Mahluji, S. (2015) · European Journal of Nutrition · doi:10.1007/s00394-015-1027-6 · Cited by 84 · see citing works

Treatment with Ginger Ameliorates Fructose-Induced Fatty Liver and Hypertriglyceridemia in Rats: Modulation of the Hepatic Carbohydrate Response Element-Binding Protein-Mediated Pathway

Gao, H., Guan, T., Li, C., Zuo, G., Yamahara, J., Wang, J., & Li, Y. (2012) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2012/570948 · Cited by 82 · see citing works

Anti‐inflammatory Effects of the Zingiber officinale roscoe Constituent 12‐Dehydrogingerdione in Lipopolysaccharide‐stimulated Raw 264.7 Cells

Han, Y. A., Song, C. W., Koh, W. S., Yon, G. H., Kim, Y. S., Ryu, S. Y., Kwon, H. J., & Lee, K. H. (2012) · Phytotherapy Research · doi:10.1002/ptr.4847 · Cited by 72 · see citing works

Zingiber officinale extract exhibits antidiabetic potential via modulating glucose uptake, protein glycation and inhibiting adipocyte differentiation: an in vitro study

Rani, M. P., Krishna, M. S., Padmakumari, K. P., Raghu, K. G., & Sundaresan, A. (2012) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.5567 · Cited by 71 · see citing works

Preventative Effect of Zingiber officinale on Insulin Resistance in a High‐Fat High‐Carbohydrate Diet‐Fed Rat Model and its Mechanism of Action

Li, Y., Tran, V. H., Kota, B. P., Nammi, S., Duke, C. C., & Roufogalis, B. D. (2014) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.12196 · Cited by 65 · see citing works

Attenuation of Liver Pro‐Inflammatory Responses by Zingiber officinale via Inhibition of NF‐kappa B Activation in High‐Fat Diet‐Fed Rats

Li, X., McGrath, K. C. Y., Nammi, S., Heather, A. K., & Roufogalis, B. D. (2011) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2011.00791.x · Cited by 63 · see citing works

Inhibition of Angiotensin-1-Converting Enzyme Activity by Two Varieties of Ginger ( Zingiber officinale ) in Rats Fed a High Cholesterol Diet

Akinyemi, A. J., Ademiluyi, A. O., & Oboh, G. (2014) · Journal of Medicinal Food · doi:10.1089/jmf.2012.0264 · Cited by 62 · see citing works

Effects of ginger on serum glucose, advanced glycation end products, and inflammation in peritoneal dialysis patients

Imani, H., Tabibi, H., Najafi, I., Atabak, S., Hedayati, M., & Rahmani, L. (2014) · Nutrition · doi:10.1016/j.nut.2014.11.020 · Cited by 62 · see citing works

Regulation of Low‐Density Lipoprotein Receptor and 3‐Hydroxy‐3‐Methylglutaryl Coenzyme A Reductase Expression by Zingiber officinale in the Liver of High‐Fat Diet‐Fed Rats

Nammi, S., Kim, M. S., Gavande, N. S., Li, G. Q., & Roufogalis, B. D. (2010) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2009.00497.x · Cited by 60 · see citing works

A Bioactive Constituent of Ginger, 6-Shogaol, Prevents Adipogenesis and Stimulates Lipolysis in 3T3-L1 Adipocytes

Suk, S., Seo, S. G., Yu, J. G., Yang, H. S., Jeong, E., Jang, Y. J., Yaghmoor, S., Ahmed, Y. M., Yousef, J. M., Abualnaja, K. O., et al. (2015) · Journal of Food Biochemistry · doi:10.1111/jfbc.12191 · Cited by 59 · see citing works

Plasma Cholesterol-Lowering Activity of Gingerol- and Shogaol-Enriched Extract Is Mediated by Increasing Sterol Excretion

Lei, L., Liu, Y., Wang, X., Jiao, R., Ma, K. Y., Li, Y. M., Wang, L., Man, S. W., Sang, S., Huang, Y., et al. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf5043344 · Cited by 58 · see citing works

Upregulation of mRNA of retinoid binding protein and fatty acid binding protein by cholesterol enriched-diet and effect of ginger on lipid metabolism

Matsuda, A., Wang, Z., Takahashi, S., Tokuda, T., Miura, N., & Hasegawa, J. (2009) · Life Sciences · doi:10.1016/j.lfs.2009.04.004 · Cited by 55 · see citing works

Hypoglycemic effect of ginger (Zingiber officinale) in alloxan induced diabetic rats (Rattus norvagicus).

Jafri, S. A., Abass, S., & Qasim, M. (2011) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 53 · see citing works

Traditional Medicinal Herbs for the Management of Diabetes and its Complications: An Evidence-Based Review

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Inhibitory effect 6-gingerol on adipogenesis through activation of the Wnt/β-catenin signaling pathway in 3T3-L1 adipocytes

Li, C., & Zhou, L. (2015) · Toxicology in Vitro · doi:10.1016/j.tiv.2015.09.023 · Cited by 51 · see citing works

PPARγ Regulation in Hypertension and Metabolic Syndrome

Stump, M., Mukohda, M., Hu, C., & Sigmund, C. D. (2015) · Current Hypertension Reports · doi:10.1007/s11906-015-0601-x · Cited by 48 · see citing works

6-Gingerol Protects against Nutritional Steatohepatitis by Regulating Key Genes Related to Inflammation and Lipid Metabolism

Tzeng, T., Liou, S., Chang, C., & Liu, I.-M. (2015) · Nutrients · doi:10.3390/nu7020999 · Cited by 46 · see citing works

Dietary Supplementation of Ginger and Turmeric Rhizomes Modulates Platelets Ectonucleotidase and Adenosine Deaminase Activities in Normotensive and Hypertensive Rats

Akinyemi, A. J., Thomé, G. R., Morsch, V. M., Bottari, N. B., Baldissarelli, J., de Oliveira, L. S., Goularte, J. F., Belló‐Klein, A., Oboh, G., & Schetinger, M. R. C. (2016) · Phytotherapy Research · doi:10.1002/ptr.5621 · Cited by 46 · see citing works

Protective Effect of Free and Bound Polyphenol Extracts from Ginger (Zingiber officinaleRoscoe) on the Hepatic Antioxidant and Some Carbohydrate Metabolizing Enzymes of Streptozotocin-Induced Diabetic Rats

Kazeem, M. I., Akanji, M. A., Yakubu, M. T., & Ashafa, A. O. T. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/935486 · Cited by 45 · see citing works

Effect of the Combination of Gelam Honey and Ginger on Oxidative Stress and Metabolic Profile in Streptozotocin-Induced Diabetic Sprague-Dawley Rats

Sani, N. F. A., Belani, L. K., Sin, C. P., Rahman, S. N. A. A., Das, S., Chi, T. Z., Makpol, S., & Yusof, Y. A. M. (2014) · BioMed Research International · doi:10.1155/2014/160695 · Cited by 44 · see citing works

[6]‐Gingerol Affects Glucose Metabolism by Dual Regulation via the AMPKα2‐Mediated AS160–Rab5 Pathway and AMPK‐Mediated Insulin Sensitizing Effects

Lee, J. O., Kim, N., Lee, H. J., Moon, J. W., Lee, S. K., Kim, S. J., Kim, J. K., Park, S. H., & Kim, H. S. (2015) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25100 · Cited by 43 · see citing works

Dose-dependent effect in the inhibition of oxidative stress and anticlastogenic potential of ginger in STZ induced diabetic rats

Kota, N., Panpatil, V., Kaleb, R., Bhaskar, V., & Polasa, K. (2012) · Food Chemistry · doi:10.1016/j.foodchem.2012.06.116 · Cited by 43 · see citing works

Effect of <scp><i>Zingiber officinale</i></scp> Supplementation on Obesity Management with Respect to the Uncoupling Protein 1 ‐3826A&gt;G and ß3‐adrenergic Receptor Trp64Arg Polymorphism

Ebrahimzadeh Attari, V., Asghari Jafarabadi, M., Zemestani, M., & Ostadrahimi, A. (2015) · Phytotherapy Research · doi:10.1002/ptr.5343 · Cited by 42 · see citing works

Zingiber officinale(Ginger): A Future Outlook on Its Potential in Prevention and Treatment of Diabetes and Prediabetic States

Roufogalis, B. D. (2014) · New Journal of Science · doi:10.1155/2014/674684 · Cited by 39 · see citing works

Effect of dietary supplementation of ginger and turmeric rhizomes on ectonucleotidases, adenosine deaminase and acetylcholinesterase activities in synaptosomes from the cerebral cortex of hypertensive rats

Akinyemi, A. J., Thomé, G. R., Morsch, V. M., Stefanello, N., da Costa, P., Cardoso, A. M., Goularte, J. F., Belló‐Klein, A., Akindahunsi, A. A., Oboh, G., et al. (2015) · Journal of Applied Biomedicine · doi:10.1016/j.jab.2015.06.001 · Cited by 38 · see citing works

Effect of salicylic acid application on biochemical changes in ginger (Zingiber officinale Roscoe)

Ghasemzadeh, A. (2012) · Journal of Medicinal Plants Research · doi:10.5897/jmpr11.1459 · Cited by 36 · see citing works

[6]-Gingerol dampens hepatic steatosis and inflammation in experimental nonalcoholic steatohepatitis

Tzeng, T., Liou, S., Chang, C. J., & Liu, I.-M. (2015) · Phytomedicine · doi:10.1016/j.phymed.2015.01.015 · Cited by 34 · see citing works

(S)-[6]-Gingerol enhances glucose uptake in L6 myotubes by activation of AMPK in response to [Ca2+]i

Li, Y., Tran, V. H., Koolaji, N., Duke, C. C., & Roufogalis, B. D. (2013) · Journal of Pharmacy & Pharmaceutical Sciences · doi:10.18433/j34g7p · Cited by 31 · see citing works

Improvement of Liquid Fructose-Induced Adipose Tissue Insulin Resistance by Ginger Treatment in Rats Is Associated with Suppression of Adipose Macrophage-Related Proinflammatory Cytokines

Wang, J., Gao, H., Ke, D., Zuo, G., Yang, Y., Yamahara, J., & Li, Y. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/590376 · Cited by 31 · see citing works

Protective Effect of Zingiber Officinale against CCl4-Induced Liver Fibrosis Is Mediated through Downregulating the TGF-ß1/Smad3 and NF-κB/IκB Pathways

Hasan, I. H., El-Desouky, M. A., Hozayen, W. G., & Aziz, G. M. A. E. –. (2015) · Pharmacology · doi:10.1159/000441229 · Cited by 27 · see citing works

Enhancement of glucose transport by selected plant foods in muscle cell line L6

Noipha, K., Ratanachaiyavong, S., & Ninla‐aesong, P. (2010) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2010.04.021 · Cited by 22 · see citing works

Chemoprevention of obesity by dietary natural compounds targeting mitochondrial regulation

Lai, C., Wu, J.-C., Ho, C., & Pan, M. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600721 · Cited by 21 · see citing works

An aqueous extract of Zingiber officinale Roscoe protects mouse primary hepatic cells against hydrogen peroxide-induced oxidative stress

Oh, S. Y., Lee, J., Lee, J. S., Seo, S.-H., & Ma, J. (2012) · Biotechnology and Bioprocess Engineering · doi:10.1007/s12257-011-0433-8 · Cited by 6 · see citing works

Effect of Ginger on Inflammatory Diseases

Ballester, P., Cerdá, B., Arcusa, R., Marhuenda, J., Yamedjeu, K., & Zafrilla, P. (2022) · Molecules · doi:10.3390/molecules27217223 · Cited by 243 · see citing works

Zingiber officinale Rosc. essential oil, a review on its composition and bioactivity

Mahboubi, M. (2019) · Clinical Phytoscience · doi:10.1186/s40816-018-0097-4 · Cited by 229 · see citing works

Potential Role of Ginger (Zingiber officinale Roscoe) in the Prevention of Neurodegenerative Diseases

Arcusa, R., Villaño, D., Marhuenda, J., Cano, M., Cerdá, B., & Zafrilla, P. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.809621 · Cited by 176 · see citing works

Phytochemicals as modifiers of gut microbial communities

Dingeo, G., Alex Brito, O., Samouda, H., Iddir, M., Frano, M. R. L., & Bohn, T. (2020) · Food & Function · doi:10.1039/d0fo01483d · Cited by 170 · see citing works

Beneficial effects of ginger on prevention of obesity through modulation of gut microbiota in mice

Wang, J., Wang, P., Li, D., Hu, X., & Chen, F. (2019) · European Journal of Nutrition · doi:10.1007/s00394-019-01938-1 · Cited by 159 · see citing works

Effects of Ginger (Zingiber officinale Roscoe) on Type 2 Diabetes Mellitus and Components of the Metabolic Syndrome: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Zhu, J., Chen, H., Song, Z., Xu-dong, W., & Sun, Z. (2018) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2018/5692962 · Cited by 137 · see citing works

Effect of ginger (Zingiber officinale) on inflammatory markers: A systematic review and meta-analysis of randomized controlled trials

Morvaridzadeh, M., Fazelian, S., Agah, S., Khazdouz, M., Rahimlou, M., Agh, F., Potter, E., Heshmati, S., & Heshmati, J. (2020) · Cytokine · doi:10.1016/j.cyto.2020.155224 · Cited by 120 · see citing works

Natural Bioactive Compounds Useful in Clinical Management of Metabolic Syndrome

Noce, A., Lauro, M. D., Daniele, F. D., Zaitseva, A. P., Marrone, G., Borboni, P., & Daniele, N. D. (2021) · Nutrients · doi:10.3390/nu13020630 · Cited by 116 · see citing works

Scalable, large-area synthesis of heteroatom-doped few-layer graphene-like microporous carbon nanosheets from biomass for high-capacitance supercapacitors

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A comparative UPLC-Q/TOF-MS-based metabolomics approach for distinguishing Zingiber officinale Roscoe of two geographical origins

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Ameliorative and protective effects of ginger and its main constituents against natural, chemical and radiation-induced toxicities: A comprehensive review

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Ginger prevents obesity through regulation of energy metabolism and activation of browning in high-fat diet-induced obese mice

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Ginger Phytochemicals Inhibit Cell Growth and Modulate Drug Resistance Factors in Docetaxel Resistant Prostate Cancer Cell

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6-Gingerol, a Functional Polyphenol of Ginger, Promotes Browning through an AMPK-Dependent Pathway in 3T3-L1 Adipocytes

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The effects of ginger supplementation on markers of inflammatory and oxidative stress: A systematic review and meta‐analysis of clinical trials

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Extensive review of popular functional foods and nutraceuticals against obesity and its related complications with a special focus on randomized clinical trials

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A Review: Is Ginger (Zingiber officinale var. Roscoe) Potential for Future Phytomedicine?

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Ginger and its bioactive component 6-shogaol mitigate lung inflammation in a murine asthma model

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Effect of ginger ( Zingiber officinale ) supplementation on oxidative stress parameters: A systematic review and meta‐analysis

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The effect of ellagic acid on the metabolic syndrome: A review article

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Ginger (Zingiber Officinale Roscoe) Extract Protects the Heart Against Inflammation and Fibrosis in Diabetic Rats

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The effects of steamed ginger ethanolic extract on weight and body fat loss: a randomized, double-blind, placebo-controlled clinical trial

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6-gingerol ameliorates metabolic disorders by inhibiting hypertrophy and hyperplasia of adipocytes in high-fat-diet induced obese mice

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Ginger: From serving table to salient therapy

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Assessing the Effects of Ginger Extract on Polyphenol Profiles and the Subsequent Impact on the Fecal Microbiota by Simulating Digestion and Fermentation In Vitro

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The Effects of Ginger ( Zingiber Officinale Roscoe) on Non-Alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus: A Randomized Double-Blinded Placebo-Controlled Clinical Trial

Ghoreishi, P. S., Shams, M., Nimrouzi, M., Zarshenas, M. M., Lankarani, K. B., Fallahzadeh, E., Talebzadeh, M., & Hashempur, M. H. (2023) · Journal of Dietary Supplements · doi:10.1080/19390211.2023.2263788 · Cited by 44 · see citing works

The antioxidant activity of steamed ginger and its protective effects on obesity induced by high-fat diet in C57BL/6J mice

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The Beneficial Effects of Essential Oils in Anti-Obesity Treatment

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Nanoparticles as phytochemical carriers for cancer treatment: News of the last decade

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Antimetabolic Syndrome Effect of Phytosome Containing the Combined Extracts of Mulberry and Ginger in an Animal Model of Metabolic Syndrome

Palachai, N., Wattanathorn, J., Muchimapura, S., & Thukham-mee, W. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/5972575 · Cited by 39 · see citing works

Fungal and mycotoxin occurrence, affecting factors, and prevention in herbal medicines: a review

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Elucidating the Beneficial Effects of Ginger (Zingiber officinale Roscoe) in Parkinson’s Disease

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A Critical Review on Obesity: Herbal Approach, Bioactive Compounds, and Their Mechanism

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In vivo, in vitro and in silico anticancer investigation of fullerene C60 on DMBA induced breast cancer in rats

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Natural products for managing metabolic syndrome: a scoping review

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Activation of AMPK by Medicinal Plants and Natural Products: Its Role in Type 2 Diabetes Mellitus

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Impact of natural products on the cholesterol transporter ABCA1

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Impact of Thermal Processing on the Selected Biological Activities of Ginger Rhizome—A Review

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The effects of ginger and its constituents in the prevention of metabolic syndrome: A review.

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Gingerenone A Sensitizes the Insulin Receptor and Increases Glucose Uptake by Inhibiting the Activity of p70 S6 Kinase

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The effects of ginger supplementation on biomarkers of inflammation and oxidative stress in adults: A systematic review and meta-analysis of randomized controlled trials

Askari, G., Aghajani, M., Salehi, M., Najafgholizadeh, A., Keshavarzpour, Z., Fadel, A., Venkatakrishnan, K., Salehi‐Sahlabadi, A., Hadi, A., & Pourmasoumi, M. (2020) · Journal of Herbal Medicine · doi:10.1016/j.hermed.2020.100364 · Cited by 26 · see citing works

The protective effects of steamed ginger on adipogenesis in 3T3-L1 cells and adiposity in diet-induced obese mice

Kim, B., Kim, H.-J., & Cha, Y. (2021) · Nutrition Research and Practice · doi:10.4162/nrp.2021.15.3.279 · Cited by 26 · see citing works

Pharmacological properties of ginger (Zingiber officinale): what do meta-analyses say? a systematic review

Paudel, K. R., Orent, J., & Penela, O. G. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1619655 · Cited by 25 · see citing works

The combination of ginger powder and zinc supplement improves the fructose‐induced metabolic syndrome in rats by modulating the hepatic expression of NF‐κB, mTORC1, PPAR‐α SREBP‐1c, and Nrf2

Mustafa, Z. A., Ali, R., Ali, D. R., Abdulkarimi, R., Abdulkareem, N. K., & Akbari, A. (2020) · Journal of Food Biochemistry · doi:10.1111/jfbc.13546 · Cited by 25 · see citing works

Zingiber officinale Rosc. in the Treatment of Metabolic Syndrome Disorders—A Review of In Vivo Studies

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The addition of spices and herbs to vegetables in the National School Lunch Program increased vegetable intake at an urban, economically-underserved, and predominantly African-American high school

D'Adamo, C. R., Parker, E. A., McArdle, P. F., Trilling, A., Bowden, B., Bahr-Robertson, M. K., Keller, K. L., & Berman, B. M. (2021) · Food Quality and Preference · doi:10.1016/j.foodqual.2020.104076 · Cited by 24 · see citing works

Modulatory functions of bioactive fruits, vegetables and spices in adipogenesis and angiogenesis

Sarkar, P. A., & Thirumurugan, K. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2018.12.036 · Cited by 22 · see citing works

Zingiber officinaleextract and omega‐3 fatty acids ameliorate endoplasmic reticulum stress in a nonalcoholic fatty liver rat model

Kandeil, M. A., Hashem, R. M., Mahmoud, M. O., Hetta, M. H., & Tohamy, M. A. (2019) · Journal of Food Biochemistry · doi:10.1111/jfbc.13076 · Cited by 22 · see citing works

The role of myocardial fibrosis in the diabetic cardiomyopathy

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Protective effects of zingerone on high cholesterol diet-induced atherosclerosis through lipid regulatory signaling pathway

Geng, X., Liu, H., Yuwen, Q., Wang, J., Zhang, S., Zhang, X., & Sun, J. (2021) · Human & Experimental Toxicology · doi:10.1177/09603271211006170 · Cited by 20 · see citing works

Encapsulation of ginger oleoresin in co-crystallized sucrose: development, characterization and storage stability

Rai, K., Chhanwal, N., Shah, N. N., & Singhal, R. S. (2021) · Food & Function · doi:10.1039/d1fo00565k · Cited by 20 · see citing works

Phytochemical profile and anti‐oxidation activity changes during ginger (Zingiber officinale) harvest: Baby ginger attenuates lipid accumulation and ameliorates glucose uptake in HepG2 cells

Li, H., Rafie, R., Xu, Z., & Siddiqui, R. A. (2021) · Food Science & Nutrition · doi:10.1002/fsn3.2654 · Cited by 20 · see citing works

6‐Dihydroparadol, a Ginger Constituent, Enhances Cholesterol Efflux from THP‐1‐Derived Macrophages

Wang, D., Hiebl, V., Ladurner, A., Latkolik, S. L., Bučar, F., Heiß, E. H., Dirsch, V. M., & Atanasov, A. G. (2018) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201800011 · Cited by 20 · see citing works

Comparative Study of Polyphenol Profile after Stimulated Post-intestinal Digestion of Raw and Dried Ginger Leaves

Okpoghono, J., Jacdonmi, O., Igue, U. B., Precious, I., Isoje, E. F., Okom, S. U., & Stephen-Onojedje, Q. O. (2023) · Annals of Science and Technology · doi:10.2478/ast-2023-0012 · Cited by 19 · see citing works

Evaluation of Ginger ( Zingiber Officinale Roscoe ) on Energy Metabolism and Obesity: Systematic Review and Meta-Analysis

Macit, M. S., Sözlü, S., Bozkurt, B. K., & Tek, N. A. (2019) · Food Reviews International · doi:10.1080/87559129.2019.1608556 · Cited by 19 · see citing works

Biological Activities of Zingiber officinale Roscoe Essential Oil against Fusarium spp.: A Minireview of a Promising Tool for Biocontrol

Radice, M., Maddela, N. R., & Scalvenzi, L. (2022) · Agronomy · doi:10.3390/agronomy12051168 · Cited by 18 · see citing works

Ginger essential oil: Chemical composition, extraction, characterization, pharmacological activities, and applications

Uddin, J., Ahmed, H., Asiri, Y. I., Kamal, G. M., & Musharraf, S. G. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-91740-7.00014-1 · Cited by 18 · see citing works

Natural compounds proposed for the management of non-alcoholic fatty liver disease

Merenda, T., Juszczak, F., Ferier, E., Duez, P., Patris, S., Declèves, A., & Nachtergael, A. (2024) · Natural Products and Bioprospecting · doi:10.1007/s13659-024-00445-z · Cited by 18 · see citing works

Moringa oleiferaLam. as a potential plant for alleviation of the metabolic syndrome—A narrative review based on in vivo and clinical studies

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The Effectiveness of Nigella sativa and Ginger as Appetite Suppressants: An Experimental Study on Healthy Wistar Rats

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Radioiodinated Ginger Compounds (6-gingerol and 6-shogaol) and Incorporation Assays on Breast Cancer Cells

Karatay, K. B., Kılçar, A. Y., Derviş, E., & Müftüler, F. Z. B. (2020) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1871520620666200128114215 · Cited by 16 · see citing works

Renoprotective effects of the ginger (Zingiber officinale) on Diabetic kidney disease, current knowledge and future direction: a systematic review of animal studies

Veisi, P., Zarezade, M., Rostamkhani, H., & Ghoreishi, Z. (2022) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-022-03768-x · Cited by 15 · see citing works

Anti‐inflammatory activity of ginger modulates macrophage activation against the inflammatory pathway of monosodium glutamate

Mousa, M. A. E. H., Mansour, H., Eid, F. A., & Mashaal, A. (2021) · Journal of Food Biochemistry · doi:10.1111/jfbc.13819 · Cited by 15 · see citing works

Zingiber officinale (Ginger) hydroalcoholic extract improved avoidance memory in rat model of streptozotocin-induced diabetes by regulating brain oxidative stress

Marefati, N., Abdi, T., Beheshti, F., Vafaee, F., Mahmoudabady, M., & Hosseini, M. (2021) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2021-0033 · Cited by 15 · see citing works

Natural Products as a Potential Source of Promising Therapeutics for COVID‐19 and Viral Diseases

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The Positive Effect of 6-Gingerol on High-Fat Diet and Streptozotocin-Induced Prediabetic Mice: Potential Pathways and Underlying Mechanisms

Wang, K., Kong, L., Wen, X., Li, M., Su, S., Ni, Y., & Gu, J. (2023) · Nutrients · doi:10.3390/nu15040824 · Cited by 14 · see citing works

The effects of medicinal and food homologous substances on blood lipid and blood glucose levels and liver function in patients with nonalcoholic fatty liver disease: a systematic review of randomized controlled trials

Zhang, Q., Jia, Y., Zhang, Y., Wang, Y., Li, X., Tian, X., & Han, S. (2023) · Lipids in Health and Disease · doi:10.1186/s12944-023-01900-5 · Cited by 14 · see citing works

Development of Standardized Prakriti Assessment Tool: An Overview of Ongoing CCRAS Initiatives

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Pharmacological Effects of Selected Medicinal Plants and Vitamins Against COVID-19

Yedjou, C. G. (2021) · doi:10.17303/jfn.2021.7.202 · Cited by 14 · see citing works

Immature ginger reduces triglyceride accumulation by downregulating Acyl CoA carboxylase and phosphoenolpyruvate carboxykinase-1 genes in 3T3-L1 adipocytes

Li, H., Rafie, A. R., Hamama, A. A., & Siddiqui, R. A. (2023) · Food & Nutrition Research · doi:10.29219/fnr.v67.9126 · Cited by 14 · see citing works

Zingiber officinale preserves testicular structure and the expression of androgen receptors and proliferating cell nuclear antigen in diabetic rats

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The Effects of Body Fat Reduction through the Metabolic Control of Steam-Processed Ginger Extract in High-Fat-Diet-Fed Mice

Lee, Y., Lee, S. R., Baek, H. J., Kwon, J. E., Baek, N., Kang, T. H., Kim, H., & Kang, S. C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052982 · Cited by 13 · see citing works

Efficacy of Ginger Supplementation in Relieving Persistent Hypothyroid Symptoms in Patients with Controlled Primary Hypothyroidism: A Pilot Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Ashraf, H., Heydari, M., Shams, M., Zarshenas, M. M., Tavakoli, A., & Sayadi, M. (2022) · Evidence-Based Complementary and Alternative Medicine · doi:10.1155/2022/5456855 · Cited by 13 · see citing works

Comprehensive analysis and therapeutic potential of ginger essential oil

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Nutraceutical management of metabolic syndrome as a palliative and a therapeutic to coronavirus disease (COVID) crisis

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Neuroprotective Effects of Shogaol in Metals (Al, As and Pb) and High-fat diet-induced Neuroinflammation and Behavior in Mice

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The effects of ginger supplementation on common gastrointestinal symptoms in patients with relapsing-remitting multiple sclerosis: a double-blind randomized placebo-controlled trial

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Medicinal Plants and Phytochemicals in Cardioprotection—Mechanistic Pathways and Translational Roadmap

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Applications of the Zingiberaceae in traditional medicine among the Dayak Tamambaloh Tribe in Labian Ira'ang and Temau Villages, Kapuas Hulu District, Indonesia

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Exploring the protective effect of Modified Xiaochaihu Decoction against hepatic steatosis and inflammation by network pharmacology and validation in ageing rats

Gao, S., Wang, T., Huang, X., Jin, Y., Xu, Y., Xi, Y., Zhang, J., Luo, Y., Xu, H., Guo, H., et al. (2020) · Chinese Medicine · doi:10.1186/s13020-020-00378-y · Cited by 11 · see citing works

Nutraceutical Potential of Ginger

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Is 6-Shogaol an Effective Phytochemical for Patients With Lower-risk Myelodysplastic Syndrome? A Narrative Review

Ooi, S. L., Campbell, R., Pak, S. C., Golombick, T., Manoharan, A., Ramakrishna, R., Badmaev, V., & Schloss, J. M. (2021) · Integrative Cancer Therapies · doi:10.1177/15347354211065038 · Cited by 11 · see citing works

Effects of Zingiber officinale extract supplementation on metabolic and genotoxic parameters in diet-induced obesity in mice

Luciano, T. F., de Souza, C. T., Pinho, R. A., Marques, S. D. O., Luiz, G. P., Tramontin, N. D. S., Silveira, P. C. L., de Andrade, V. M., & Muller, A. P. (2020) · British Journal Of Nutrition · doi:10.1017/s0007114520005073 · Cited by 10 · see citing works

Ginger ( Zingiber officinale Rosc. ) Ameliorated Metabolic and Inflammatory Dysfunction Induced by High-Refined Carbohydrate-Containing Diet in Mice

Oliveira, C. T., Lacerda, D. R., Zicker, M. C., Martins, L. B., Teixeira, M. M., de Araújo, R. L. B., & Ferreira, A. V. M. (2018) · Journal of Medicinal Food · doi:10.1089/jmf.2018.0062 · Cited by 10 · see citing works

Safety and antioxidant potential of traditional thai poly-herbal tea “phy-blica-d” used as a rejuvenation formula

Chusri, S., Issuriya, A., Puangkeaw, N., Choochana, P., Jaisamut, P., Kunworarath, N., Maneenoon, K., Limsuwan, S., & Kaewmanee, T. (2019) · Pharmacognosy Research · doi:10.4103/pr.pr_5_19 · Cited by 10 · see citing works

Effects of medical plants from Zingiberaceae family on cardiovascular risk factors of type 2 diabetes mellitus: A systematic review and meta‐analysis of randomized controlled trials

Zhang, X., Chen, X., Tang, Y., Guan, X.-X., Deng, J., & Fan, J. (2022) · Journal of Food Biochemistry · doi:10.1111/jfbc.14130 · Cited by 9 · see citing works

The Effect of Ginger (Zingiber officinale Roscoe) Aqueous Extract on Postprandial Glycemia in Nondiabetic Adults: A Randomized Controlled Trial

Diakos, A., Silva, M. L., Brito, J., Moncada, M. M., de Mesquita, M. F., & Bernardo, A. (2023) · Foods · doi:10.3390/foods12051037 · Cited by 9 · see citing works

Ginger Extract Ameliorates Renal Damage in High Fat Diet-Induced Obesity in Rats: Biochemical and Ultrastructural Study

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10‑Gingerol, a novel ginger compound, exhibits antiadipogenic effects without compromising cell viability in 3T3‑L1 cells

Preciado-Ortiz, M. E., Martínez‐López, E., Rodriguez‐Echevarría, R., Pérez-Robles, M., Gembe‐Olivarez, G., & Rivera-Valdes, J. J. (2023) · Biomedical Reports · doi:10.3892/br.2023.1687 · Cited by 9 · see citing works

Genetic diversity and utilization of ginger (Zingiber officinale) for varietal improvement: A review

Oladosu, Y. A., Rafii, M. Y., Arolu, F., Murugesu, S., Chukwu, S. C., Salisu, M. A., Fagbohun, I. K., Muftaudeen, T. K., & Kadar, A. I. (2024) · AIMS Agriculture and Food · doi:10.3934/agrfood.20240011 · Cited by 8 · see citing works

Ginger: a total-scale analysis of the scientific literature on a widely used spice and phytotherapeutic

Matin, M., Yeung, A. W. K., Joshi, T., Tzvetkov, N. T., Matin, F. B., Strzałkowska, N., Ksepka, N., Wysocki, K., Tomasik, C., Mickael, M., et al. (2024) · Animal Science Papers and Reports · doi:10.2478/aspr-2023-0042 · Cited by 8 · see citing works

Phytochemicals, Their Intestinal Metabolites, and Skeletal Muscle Function

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A helper T cell clone produces an antigen-specific molecule (T-ABM) which functions in the induction of suppression.

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Comprehensive study on the impact of ginger extract on laying performance, egg quality, inflammatory responses, intestinal barrier function, and cecal microbiome and resistome in laying hens

Tong, Y., Wang, Y., Zhang, J., Guo, Y., Yuan, T., Chen, H., Zhang, H., Zhan, K., Zhao, L., Ma, Q., et al. (2025) · Poultry Science · doi:10.1016/j.psj.2025.105448 · Cited by 6 · see citing works

Impact of ginger supplementation on obesity indices and Adipokine profiles in adults: A GRADE-based systematic review and dose-response meta-analysis of randomized controlled trials

Rjabi, S., Seyedhatami, S. S., Makhtoomi, M., Ahmadi, M. R., Alimohamadi, S., Aliabadi, E., Talakesh, S., Nouri, M., Zamani, B., & Askarpour, M. (2025) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2025.103260 · Cited by 6 · see citing works

Effectiveness of Ginger in the Treatment of Type 2 Diabetes Mellitus: A Pilot Study of the Randomized Clinical Trial Type

Carvalho, G. C. N., Neto, J. C. G. L., Nunes, L. C. C., Alencar, A. M. P. G., Marques, R. L. L., & Damasceno, M. M. C. (2021) · Aquichan · doi:10.5294/aqui.2021.21.1.5 · Cited by 6 · see citing works

Association between intensive health guidance focusing on eating quickly and metabolic syndrome in Japanese middle-aged citizens

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Gingerol supplementation does not change glucose tolerance, lipid profile and does not prevent weight gain in C57BL/6 mice fed a high-fat diet

Zordan, A. J. C. M., Silva, C. B., Joaquim, A. G., Rodrigues, M., Machado, C. D., Carlos, D., Foss‐Freitas, M. C., & Suen, V. M. M. (2020) · Clinical Nutrition Experimental · doi:10.1016/j.yclnex.2020.05.001 · Cited by 5 · see citing works

Neurohistopathological Alterations Induced by Theobroma Cacao and Camellia Sinensis Extracts in Diabetic Male Wistar Rats

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Zingiber officinale Rosc. in the Treatment of Metabolic Syndrome Disorders—A Review of In Vivo Studies

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ZINGIBER OFFICINALE IMPACT ON METABOLIC SYNDROME, OBESITY, AND INSULIN RESISTANCE

kizi, M. M. S. (2025) · Ethiopian International Journal of Multidisciplinary Research

Evaluation of Ginger ( Zingiber Officinale Roscoe ) on Energy Metabolism and Obesity: Systematic Review and Meta-Analysis

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A systematic review of the anti‐obesity and weight lowering effect of ginger (Zingiber officinale Roscoe) and its mechanisms of action

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Ginger: Warming the metabolism

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