Effect of dietary fiber on circulating C-reactive protein in overweight and obese adults: a meta-analysis of randomized controlled trials
Abstract
Previous studies suggested that dietary fiber intake may have a lowing effect on circulating C-reactive protein (CRP) level, a sensitive marker of inflammation, in overweight/obese adults with inconsistent results. A literature search was performed in April 2014 for related randomized controlled trials (RCTs) and meta-analysis was conducted. Meta-analysis including 14 RCTs showed that intervention with dietary fiber or fiber-rich food, compared with control, produced a slight, but significant reduction of 0.37 mg/L (95% CI -0.74, 0) in circulating CRP level among this population. Subgroup analyses showed that such a significant reduction was only observed after combining studies where the total fiber intake was 8 g/d higher in the intervention group than in the control group. No obvious heterogeneity and publication bias were found in the meta-analysis. In conclusion, this meta-analysis provides evidence that dietary fiber or food naturally rich in fiber has beneficial effects on circulating CRP level in overweight/obese adults.
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Nuts and plant sterols have demonstrated only a non-significant tendency for CRP reductions.
“while nuts and plant sterols have demonstrated only a non-significant tendency for CRP reductions.44”
From Portfolio Dietary Pattern and Cardiovascular Disease: A Systematic Review and Meta-analysis of Controlled Trials (2018) · cites this paper as [44]
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References 35 · Cited by 93
- Authors
- Jiao, J., Xu, J.-Y., Zhang, W., Han, S., & Qin, L.-Q.
- Affiliations
- Soochow University (CN)
- Corresponding author
- Han, Shufen
- Qin, Li-Qiang
- Venue
- International Journal of Food Sciences and Nutrition
- Publisher
- Informa UK Limited
- Published
- 2015-01-02
- Volume
- 66
- Issue
- 1
- Pages
- 114-119
- ISSN
- 0963-7486 (ISSN-L)
- 1465-3478
- OpenAlex
- W2094565792
- Cited by
- 93
- References
- 35
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 11 · 2023: 5 · 2022: 7 · 2021: 8 · 2020: 6 · 2019: 8 · 2018: 16 · 2017: 16 · 2016: 4
- FWCI
- 1.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Food Sciences and Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- dietary fiber, C-reactive protein, inflammation, overweight, obesity, fiber-rich foods, dietary intervention
- MeSH terms
- C-Reactive Protein, Dietary Fiber, Humans, Obesity, Sensitivity and Specificity, Randomized Controlled Trials as Topic, Databases, Factual, Overweight
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