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Bacterial degradation of strobilurin fungicides: a role for a promiscuous methyl esterase activity of the subtilisin proteases?

Clinton, Brook, Warden, Andrew C., Haboury, Stephanie, Easton, Christopher J., Kotsonis, Steven, Taylor, Matthew C., Oakeshott, John G., Russell, Robyn J., Scott, Colin·2011·Biocatalysis and Biotransformation
DOI 10.3109/10242422.2011.578740
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Abstract

Strobilurin fungicides are some of the most heavily used antifungal chemicals in agriculture. However, little is known of their fate in the environment. We have identified bacteria that slowly transform strobilurin fungicides via hydrolysis of a methyl ester group in the toxophore, rendering them non-fungicidal. A carboxypeptidase (subtilisin Carlsberg) was found to have this activity, albeit with low specific activity (2.4 × 10−2 nmol s−1 mg−1), and to possess specificity towards an analog of the fungicidal isomer of commercial strobilurins. Substrate-docking studies using the known structure for subtilisin Carlsberg revealed a plausible explanation for both the activity and isomer specificity of this class of hydrolase. These findings suggest that the promiscuous strobilurin methyl esterase activity of the subtilisin-like carboxypeptidases may have a role in the environmental fate of the strobilurin fungicides.

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Metadata

Authors
Clinton, B., Warden, A. C., Haboury, S., Easton, C. J., Kotsonis, S., Taylor, M. C., Oakeshott, J. G., Russell, R. J., & Scott, C.
Venue
Biocatalysis and Biotransformation
Publisher
Informa UK Limited
Published
2011-07-04
Volume
29
Issue
4
Pages
119-129
ISSN
  • 1024-2422
  • 1029-2446
DOI
10.3109/10242422.2011.578740
Cited by
31
References
0
Language
en

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CoChat. (2026). Citation check: Bacterial degradation of strobilurin fungicides: a role for a promiscuous methyl esterase activity of the subtilisin proteases? https://app.cochat.ai/papers/10.3109/10242422.2011.578740
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Clinton, B., Warden, A. C., Haboury, S., Easton, C. J., Kotsonis, S., Taylor, M. C., Oakeshott, J. G., Russell, R. J., & Scott, C. (2011). Bacterial degradation of strobilurin fungicides: a role for a promiscuous methyl esterase activity of the subtilisin proteases? Biocatalysis and Biotransformation. https://doi.org/10.3109/10242422.2011.578740