The Enhancement of Hippocampal Primed Burst Potentiation by Dehydroepiandrosterone Sulfate (DHEAS) is Blocked by Psychological Stress
Abstract
This series of studies investigated the effects of psychological stress and the neurosteroid dehydroepiandrosterone sulfate (DHEAS) on hippocampal primed burst (PB) and long-term (LTP) potentiation, two electrophysiological models of memory. The DHEAS and stress manipulations were performed on awake rats, and then PB and LTP were recorded while the rats were anesthetized. DHEAS enhanced PB potentiation when administered to rats under non-stress conditions, but had no effect when given to stressed rats. Further study showed that DHEAS enhanced PB potentiation only when it was administered before, but not after, the rats were stressed. The DHEAS and stress manipulations had no effect on LTP. This study provides three major findings regarding stress, neurosteroids and hippocampal plasticity. First, DHEAS enhanced a threshold form of plasticity (PB potentiation), but had no effect on a supra-threshold form of plasticity (LTP). Second, stress blocked the DHEAS-induced enhancement of PB potentiation. Third, stress and DHEAS effects on the hippocampus were so durable they could be performed on awake animals and then be studied while the animals were anesthetized. That DHEAS enhanced a subset of forms of hippocampal plasticity under restricted behavioral conditions may help to resolve conflicting observations of DHEAS effects on cognition and mood in people.
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Stress blocked the induction of PB potentiation in vivo and in vitro.
“and blocked the induction of PB potentiation in vivo (Diamond et al. [139]; Vouimba et al. [140]) and in vitro (Mesches et al. [51]).”
From The Temporal Dynamics Model of Emotional Memory Processing: A Synthesis on the Neurobiological Basis of Stress-Induced Amnesia, Flashbulb and Traumatic Memories, and the Yerkes-Dodson Law (2007) · cites this paper as Diamond et al. [139]
Stress or stress-related neuromodulators block LTP produced by relatively weak (primed burst or theta burst) tetanizing stimulation, but stress has no effect on LTP produced by stronger forms of tetanizing stimulation.
“Moreover, in electrophysiological studies, stress or stress-related neuromodulators have been shown to block LTP produced by relatively weak (primed burst or theta burst) tetanizing stimulation, but stress has been shown to have no effect on LTP produced by stronger forms of tetanizing stimulation (Corradetti et al. [283]; Mesches et al. [51]; Diamond et al. [139]; Alfarez et al. [152]; Vouimba et”
From The Temporal Dynamics Model of Emotional Memory Processing: A Synthesis on the Neurobiological Basis of Stress-Induced Amnesia, Flashbulb and Traumatic Memories, and the Yerkes-Dodson Law (2007) · cites this paper as Diamond et al. [139]
Cites
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Induction of synaptic potentiation in hippocampus by patterned stimulation involves two events
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Effects of glucocorticoids on hippocampal long‐term potentiation
Pavlides, C., Watanabe, Y., & McEwen, B. S. (1993) · Hippocampus · doi:10.1002/hipo.450030210 · Cited by 323 · see citing works
Exposing Rats to a Predator Blocks Primed Burst Potentiation in the Hippocampus<i>In Vitro</i>
Mesches, M. H., Fleshner, M., Heman, K. L., Rose, G. M., & Diamond, D. M. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-14-j0004.1999 · Cited by 276 · see citing works
Self-citationDehydroepiandrosterone and its sulfate enhance memory retention in mice.
Flood, J. F., Smith, G. E., & Roberts, E. (1988) · Brain Research · doi:10.1016/0006-8993(88)91129-8 · Cited by 227 · see citing works
Type I adrenal steroid receptors prolong hippocampal long-term potentiation
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Diamond, D. M., Campbell, A. M., Park, C. R., Halonen, J., & Zoladz, P. R. (2007) · Neural Plasticity · doi:10.1155/2007/60803 · Cited by 762 · see citing works
“…impaired hippocampus-dependent memory (Diamond et al. [134]; Diamond et al. [52]; Woodson et al. [135]; Sandi et al. [136]; Diamond et al. [137]; Park et al. [138]) and blocked the induction of PB potentiation in vivo (Di-amond et al. [139]; Vouimba et al. [140]) and in vitro (Mesches et al. [51]).”
BackgroundSelf-citationExposing Rats to a Predator Blocks Primed Burst Potentiation in the Hippocampus<i>In Vitro</i>
Mesches, M. H., Fleshner, M., Heman, K. L., Rose, G. M., & Diamond, D. M. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-14-j0004.1999 · Cited by 276 · see citing works
Self-citationNeurosteroid Actions in Memory and Neurologic/Neuropsychiatric Disorders
Ratner, M. H., Kumaresan, V., & Farb, D. H. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00169 · Cited by 96 · see citing works
Vouimba, R.-M., Muñoz, C., & Diamond, D. M. (2006) · Stress · doi:10.1080/10253890600610973 · Cited by 96 · see citing works
Self-citation
- Authors
- Diamond, D. M., Fleshner, M., & Rose, G. M.
- Affiliations
- University of South Florida (US)
- University of Colorado Boulder (US)
- Corresponding author
- Diamond, David M.
- Venue
- Stress
- Publisher
- Informa UK Limited
- Published
- 1999-01
- Volume
- 3
- Issue
- 2
- Pages
- 107-121
- ISSN
- 1025-3890 (ISSN-L)
- 1607-8888
- OpenAlex
- W1971989539
- Cited by
- 24
- References
- 6
- Citations by year
- 2019: 2 · 2015: 2 · 2014: 1 · 2013: 2 · 2012: 1
- FWCI
- 0.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Stress (publishedVersion)
- PubMed (publishedVersion)
- Digital Commons - University of South Florida (University of South Florida) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- dehydroepiandrosterone sulfate, psychological stress, hippocampus, long-term potentiation, hippocampal plasticity, neurosteroids, memory
- MeSH terms
- Animals, Corticosterone, Electrophysiology, Hippocampus, Male, Neuronal Plasticity, Stress, Psychological, Rats, Sprague-Dawley, Long-Term Potentiation, Dehydroepiandrosterone Sulfate, Rats
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