Type I adrenal steroid receptors prolong hippocampal long-term potentiation
Abstract
The effects of Type I adrenal steroid receptors in prolonging synaptic plasticity in the dentate gyrus of freely behaving rats was investigated. Rats were implanted with chronic, bilateral stimulating and recording electrodes in the perforant pathway and dentate gyrus, respectively, and adrenalectomized (ADX). After a 2-3 day recovery period, baseline recordings of field potentials were made followed by administration of aldosterone or vehicle. One hour later, high frequency stimulation (HFS; chosen to produce comparable long-term potentiation (LTP) in the aldosterone-treated and control groups) was applied unilaterally and recording was continued for 1 h and again performed at 3, 24 and 48 h. LTP in ADX controls decayed significantly within 3 h, and returned to baseline levels at 24 h. In contrast, the aldosterone-treated animals showed enhanced LTP at 3, 24 and 48 h. These findings demonstrate that aldosterone both enhances and prolongs hippocampal plasticity.
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Adrenal steroids exert biphasic effects on excitability of hippocampal neurons in terms of long-term potentiation and primed burst potentiation.
“Adrenal steroids exert biphasic effects on excitability of hippocampal neurons in terms of long-term potentiation and primed burst potentiation (Diamond et al., 1992; Pavlides et al., 1994; Pavlides et al., 1995)”
From Central effects of stress hormones in health and disease: understanding the protective and damaging effects of stress and stress mediators (2008) · cites this paper as Pavlides et al., 1994
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“Moreover, in awake, freely moving ADX rats, enhancement of LTP by the type I receptor agonist aldosterone lasts for at least 24 h, at which time it is still markedly higher than in ADX rats given only vehicle treatment before LTP induction (130).”
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- Authors
- Pavlides, C., Kimura, A., Magarinos, A.-M., & McEwen, B. S.
- Affiliations
- Rockefeller University (US)
- Venue
- Neuroreport
- Published
- 1994-12
- Volume
- 5
- Issue
- 18
- Pages
- 2673-2677
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W2093034762
- Cited by
- 76
- References
- 0
- Citations by year
- 2024: 1 · 2019: 1 · 2018: 1 · 2017: 6 · 2016: 1 · 2013: 1 · 2012: 7
- FWCI
- 1.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH-41256)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- aldosterone, long-term potentiation, hippocampus, dentate gyrus, perforant path, synaptic plasticity, adrenalectomy, high-frequency stimulation, field potentials, freely moving rats
- MeSH terms
- Adrenal Glands, Adrenalectomy, Aldosterone, Animals, Electric Stimulation, Hippocampus, Male, Receptors, Steroid, Time Factors, Rats, Sprague-Dawley, Long-Term Potentiation, Rats
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