Horizontal gene transfer in human pathogens
Abstract
Horizontal gene transfer has a tremendous impact on the genome plasticity, adaptation and evolution of bacteria. Horizontally transferred mobile genetic elements are involved in the dissemination of antibiotic resistance and virulence genes, thus contributing to the emergence of novel "superbugs". This review provides update on various mechanisms of horizontal gene transfer and examines how horizontal gene transfer contributes to the evolution of pathogenic bacteria. Special focus is paid to the role horizontal gene transfer plays in pathogenicity of the emerging human pathogens: hypervirulent Clostridium difficile and Escherichia coli (including the most recent haemolytic uraemic syndrome outbreak strain) and methicillin-resistant Staphylococcus aureus (MRSA), which have been associated with largest outbreaks of infection recently.
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Horizontal gene transfer can have an impact on the evolution of microbial communities, including pathogenic bacteria, via ARGs, virulence factors or other diverse biological functions.
“HGT can have an impact on the evolution of microbial communities including pathogenic bacteria, via ARGs, virulence factors or other diverse biological functions which can be encoded on horizontally transferred genes (Juhas, 2015; Lopatkin et al., 2016).”
From Review of emerging contaminants in green stormwater infrastructure: antibiotic resistance genes, microplastics, tire wear particles, PFAS, and temperature (2024) · cites this paper as Juhas, 2015
Cites
Clostridium difficile infection: new developments in epidemiology and pathogenesis
Rupnik, M., Wilcox, M. H., & Gerding, D. N. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2164 · Cited by 1,380 · see citing works
Wang, R., Braughton, K. R., Kretschmer, D., Bach, T.-H. L., Queck, S. Y., Li, M., Kennedy, A. D., Dorward, D. W., Klebanoff, S. J., Peschel, A., et al. (2007) · Nature Medicine · doi:10.1038/nm1656 · Cited by 1,046 · see citing works
Li, M., Diep, B. A., Villaruz, A. E., Braughton, K. R., Jiang, X., DeLeo, F. R., Chambers, H. F., Lu, Y., & Otto, M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900743106 · Cited by 394 · see citing works
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Antibiotic-free selection in biotherapeutics: Now and forever
Mignon, C., Sodoyer, R., & Werle, B. (2015) · Pathogens · doi:10.3390/pathogens4020157 · Cited by 87 · see citing works
Bodus, B., O'Malley, K., Dieter, G., Gunawardana, C., & McDonald, W. (2024) · Science of The Total Environment · doi:10.1016/j.scitotenv.2023.167195 · Cited by 76 · see citing works
Models for Gut-Mediated Horizontal Gene Transfer by Bacterial Plasmid Conjugation
Ott, L. C., & Mellata, M. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.891548 · Cited by 32 · see citing works
- Authors
- Juhas, M.
- Venue
- Critical Reviews in Microbiology
- Publisher
- Informa UK Limited
- Published
- 2013-07-18
- Volume
- 41
- Issue
- 1
- Pages
- 101-108
- ISSN
- 1040-841X
- 1549-7828
- Cited by
- 198
- References
- 3
- Language
- en
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