The DOI matches its Crossref record; 98 of the 98 references it cites were found in a registry or an index.
Hormetic mechanisms
Abstract
This article provides the first extensive documentation of mechanisms of hormetic dose/concentration responses. The mechanisms selected were principally those mediated via receptor and/or cell signaling pathways. Mechanisms are reported for greater than 100 agents affecting nearly 400 dose/concentration responses from a wide range of chemical classes, affecting a broad range of cell types and endpoints. Regardless of the model (i.e. in vitro or in vivo), inducing agent, endpoint, or receptor/cell signaling pathway mediated mechanism, the quantitative features of the hormetic dose/concentration responses are similar, suggesting that the magnitude of the response is a measure of biological plasticity, within a broad range of biological contexts. These findings represent an important advance in the understanding of the hormetic dose/concentration response, its generalizability and potential biomedical applications, including drug discovery/efficacy assessment and the risk assessment process.
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Cites
Mattson, M. P. (2008) · Ageing Research Reviews · doi:10.1016/j.arr.2007.08.007 · Cited by 1,253
Calabrese, E. J., & Baldwin, L. A. (2002) · Human & Experimental Toxicology · doi:10.1191/0960327102ht217oa · Cited by 752
Self-citationPicomolar Amyloid-β Positively Modulates Synaptic Plasticity and Memory in Hippocampus
Puzzo, D., Privitera, L., Leznik, E., Fà, M., Staniszewski, A., Palmeri, A., & Arancio, O. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2692-08.2008 · Cited by 740
Hormesis: Why it is important to toxicology and toxicologists
Calabrese, E. J. (2008) · Environmental Toxicology and Chemistry · doi:10.1897/07-541.1 · Cited by 730
Self-citationHormesis — The stimulation of growth by low levels of inhibitors
Stebbing, A. R. D. (1982) · Science of The Total Environment · doi:10.1016/0048-9697(82)90066-3 · Cited by 714
Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver
Duranski, M. R., Greer, J. J. M., Dejam, A., Jaganmohan, S., Hogg, N., Langston, W., Patel, R. P., Yet, S.-F., Wang, X., Kevil, C. G., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci22493 · Cited by 674 · cited 2×
“While the strong majority of the hormetic mechanism studies are performed within an in vitro system, some experiments employed whole animals (Boccia et al., 1998; Duranski et al., 2005; Homayoun et al., 2002; Houshmand et al., 2009; Kawabata et al., 1994; Kelly et al., 2010; Kim et al., 2008; Ogura et al., 2009; Roger…”
BackgroundCALABRESE, E., & BLAIN, R. (2005) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2004.06.023 · Cited by 557
Self-citationHormesis: U-shaped dose responses and their centrality in toxicology
Calabrese, E. J., & Baldwin, L. A. (2001) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01719-3 · Cited by 458
Self-citationThe Frequency of U-Shaped Dose Responses in the Toxicological Literature
Calabrese, E. J. (2001) · Toxicological Sciences · doi:10.1093/toxsci/62.2.330 · Cited by 436
Self-citationCalabrese, E. J., & Blain, R. B. (2009) · Environmental Pollution · doi:10.1016/j.envpol.2008.07.028 · Cited by 429
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Health effects and toxicity mechanisms of rare earth elements—Knowledge gaps and research prospects
Pagano, G., Guida, M., Tommasi, F., & Oral, R. (2015) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2015.01.030 · Cited by 590
How does hormesis impact biology, toxicology, and medicine?
Calabrese, E. J., & Mattson, M. P. (2017) · npj Aging and Mechanisms of Disease · doi:10.1038/s41514-017-0013-z · Cited by 593
Self-citationInflammasomes, hormesis, and antioxidants in neuroinflammation: Role of NRLP3 in Alzheimer disease
Pennisi, M., Crupi, R., Di Paola, R., Ontario, M. L., Bella, R., Calabrese, E. J., Crea, R., Cuzzocrea, S., & Calabrese, V. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.23986 · Cited by 157
Current nutritional and pharmacological anti-aging interventions
Ros, M., & Carrascosa, J. M. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.165612 · Cited by 86
Jang, D., Morgan, S. J., Klubo-Gwiezdzinska, J., Banga, J. P., Neumann, S., & Gershengorn, M. C. (2020) · Thyroid® · doi:10.1089/thy.2019.0418 · Cited by 19
Metadata
- Authors
- Calabrese, E. J.
- Venue
- Critical Reviews in Toxicology
- Publisher
- Informa UK Limited
- Published
- 2013-07-23
- Volume
- 43
- Issue
- 7
- Pages
- 580-606
- ISSN
- 0045-6446 (ISSN-L)
- 1040-8444
- 1547-6898
- OpenAlex
- W4233403863
- Cited by
- 380
- References
- 98
- FWCI
- 21.15
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
