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Current nutritional and pharmacological anti-aging interventions

Ros, Manuel, Carrascosa, José María·2020·Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
DOI 10.1016/j.bbadis.2019.165612
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Abstract

Aging is the main risk factor for chronic diseases and disablement in human societies with a great impact in social and health care expenditures. So far, aging and, eventually, death are unavoidable. Nevertheless, research efforts on aging-associated diseases with the aim not only to extend life span but also to increment health span in an attempt to delay, stop and even reverse the aging process have not stopped growing. Caloric restriction extends both health and life span in several short-lived experimental models and has brought to light the role of different molecular effectors involved in nutrient sensing pathways and longevity. This opens the possibility of modulating these molecular effectors also in humans to increase longevity and health span. The difficulty to implement caloric restricted diets in humans has led to the development of new bearable diets such as time-restricted feeding, intermittent fasting or diets with limited amounts of some nutrients and to the search of pharmacological agents, targeted to the effectors that mediate the extension of life and health span in response to these anti-aging diets. Pharmacological approaches that eliminate senescent cells or prevent primary causes of aging such as telomere attrition also emerge as potential anti-aging strategies. In the present article, we review these possible nutritional and pharmacological interventions designed to mitigate and/or delay the aging process and to increase health and life span.

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  • Multiple interventions, acting at different levels, can delay or even reverse the aging process.

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    From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [16]

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Metadata

Authors
Ros, M., & Carrascosa, J. M.
Venue
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Publisher
Elsevier BV
Published
2020-03
Volume
1866
Issue
3
Pages
165612
ISSN
0925-4439
DOI
10.1016/j.bbadis.2019.165612
Cited by
86
References
37
Language
en
Licence
Funders
  • Consejería de Educación, Juventud y Deporte, Comunidad de Madrid (S2017/BMD-3684)
  • Ministerio de Economía y Competitividad (BFU2017-90578-REDT, SAF2015-65267-R)
  • Comunidad de Madrid
  • Ministerio de Economía, Industria y Competitividad, Gobierno de España
  • Fundación Ramón Areces

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