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A Critical Review of the Toxicology of Glutaraldehyde
Abstract
Glutaraldehyde, a low molecular weight aldehyde, has been investigated for toxicity in humans and animals. Examination of this dialdehyde was indicated from previous studies with other aldehydes in which carcinogenicity of formaldehyde and toxicity of acetaldehyde and malonaldehyde have been disclosed. Information gaps concerning the actions of glutaraldehyde have been identified in this review and recommendations are suggested for additional short- and long-term studies. In particular, information regarding irritation of the respiratory tract, potential neurotoxicity, and developmental effects would assist in a complete hazard evaluation of glutaraldehyde. Further study related to disposition, metabolism, and reactions of glutaraldehyde may elucidate the mechanism of action.
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Citations
Cited by
Riess, J. G. (2001) · Chemical Reviews · doi:10.1021/cr970143c · Cited by 773
Hamouda, T., & Baker, J. R. (2000) · Journal of Applied Microbiology · doi:10.1046/j.1365-2672.2000.01127.x · Cited by 277
Excessive use of disinfectants against COVID-19 posing a potential threat to living beings
Ghafoor, D., Khan, Z., Khan, A., Ualiyeva, D., & Zaman, N. (2021) · Current Research in Toxicology · doi:10.1016/j.crtox.2021.02.008 · Cited by 151
Metadata
- Authors
- Beauchamp, R. O., St Clair, M. B. G., Fennell, T. R., Clarke, D. O., Morgan, K. T., & Karl, F. W.
- Venue
- Critical Reviews in Toxicology
- Publisher
- Informa UK Limited
- Published
- 1992-01
- Volume
- 22
- Issue
- 3-4
- Pages
- 143-174
- ISSN
- 0045-6446 (ISSN-L)
- 1040-8444
- 1547-6898
- OpenAlex
- W2146569034
- Cited by
- 223
- References
- 0
- FWCI
- 1.22
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: A Critical Review of the Toxicology of Glutaraldehyde. https://app.cochat.ai/papers/10.3109/10408449209145322
- The paper
- Beauchamp, R. O., St Clair, M. B. G., Fennell, T. R., Clarke, D. O., Morgan, K. T., & Karl, F. W. (1992). A Critical Review of the Toxicology of Glutaraldehyde. Critical Reviews in Toxicology. https://doi.org/10.3109/10408449209145322
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
