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Local Supercoil-Stabilized DNA Structure

Paleček, E.·1991·Critical Reviews in Biochemistry and Molecular Biology

Abstract

The DNA double helix exhibits local sequence-dependent polymorphism at the level of the single base pair and dinucleotide step. Curvature of the DNA molecule occurs in DNA regions with a specific type of nucleotide sequence periodicities. Negative supercoiling induces in vitro local nucleotide sequence-dependent DNA structures such as cruciforms, left-handed DNA, multistranded structures, etc. Techniques based on chemical probes have been proposed that make it possible to study DNA local structures in cells. Recent results suggest that the local DNA structures observed in vitro exist in the cell, but their occurrence and structural details are dependent on the DNA superhelical density in the cell and can be related to some cellular processes.

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Metadata

Authors
Paleček, E.
Venue
Critical Reviews in Biochemistry and Molecular Biology
Published
1991-01
Volume
26
Issue
2
Pages
151-226
ISSN
  • 0045-6411 (ISSN-L)
  • 1040-9238
  • 1549-7798
OpenAlex
W2123786201
Cited by
250
References
0
FWCI
2.59
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Local Supercoil-Stabilized DNA Structure. https://app.cochat.ai/papers/10.3109/10409239109081126
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Paleček, E. (1991). Local Supercoil-Stabilized DNA Structure. Critical Reviews in Biochemistry and Molecular Biology. https://doi.org/10.3109/10409239109081126

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