Effects of Alpha-Interferon on Serum Beta-2-Microglobulin
Abstract
Beta-2-microglobulin (B2M) forms the small invariable light chain subunit of class I HLA antigens on the cell membrane of all nucleated cells. During the continuous turnover of the HLA molecules, B2M is shed from the cell membrane into blood. Lymphocytes are the main source of serum free B2M. Serum B2M concentration is increased in renal diseases, various malignant diseases and some inflammatory and autoimmune disorders. In lymphatic malignancies serum B2M has significant prognostic value. Interferons (IFNs) have the ability to enhance the expression of class I and II histocompatibility antigens. Accordingly, IFNs cause a rise in formation and release of B2M. Currently, treatment with IFN alpha is used in diseases, like multiple myeloma, where serum B2M measurements are used to assess tumor burden. We have measured serum B2M levels during IFN alpha treatment in patients with both multiple myeloma and chronic myeloproliferative diseases, and IFN alpha caused a significant increase in serum B2M. It can be concluded that use of IFN alpha abolishes the value of serum B2M as an indicator of disease activity.
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The changes in both B2M and IGHE can be explained by increased interferon signaling.
“the changes in both B2M and IGHE can be explained by increased interferon signaling21–24.”
From Trisomy 21 causes changes in the circulating proteome indicative of chronic autoinflammation (2017) · cites this paper as [23]
Cites
Ford, R. C., & Eisenberg, S. (1990) · Nursing Clinics of North America · doi:10.1016/s0029-6465(22)02934-6 · Cited by 2,734 · see citing works
Isolation and Properties of a Low Molecular Weight β2-Globulin Occurring in Human Biological Fluids
Berggård, I., & Bearn, A. G. (1968) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)93284-9 · Cited by 740 · see citing works
The interferons. Mechanisms of action and clinical applications
Baron, S. (1991) · JAMA · doi:10.1001/jama.266.10.1375 · Cited by 569 · see citing works
Reid, R. P., DeVita, V. T., Hellman, S., & Rosenberg, S. A. (1992) · Histopathology · doi:10.1111/j.1365-2559.1992.tb00973.x · Cited by 473 · see citing works
Preferential effect of γ interferon on the synthesis of HLA antigens and their mRNAs in human cells
Wallach, D., Fellous, M. M., & Revel, M. (1982) · Nature · doi:10.1038/299833a0 · Cited by 386 · see citing works
Mandelli, F., Avvisati, G., Amadori, S., Boccadoro, M., Gernone, A., Lauta, V. M., Marmont, F., Petrucci, M. T., Tribalto, M., Vegna, M. L., et al. (1990) · New England Journal of Medicine · doi:10.1056/nejm199005173222005 · Cited by 382 · see citing works
Solal‐Céligny, P., Lepage, É., Brousse, N., Reyes, F., Haïoun, C., Leporrier, M., Peuchmaur, M. M., Bosly, A., Parlier, Y., Brice, P., et al. (1993) · New England Journal of Medicine · doi:10.1056/nejm199311253292203 · Cited by 266 · see citing works
The Serum Levels and Urinary Excretion of β2-Microglobulin in Apparently Healthy Subjects
Evrin, P., & Wibell, L. B. (1972) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365517209081057 · Cited by 254 · see citing works
Cresswell, P., Springer, T. A., Strominger, J. L., Turner, M. J., Grey, H. M., & Kubo, R. T. (1974) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.71.5.2123 · Cited by 204 · see citing works
Bataille, R., Grenier, J., & Sany, J. (1984) · Blood · doi:10.1182/blood.v63.2.468.468 · Cited by 186 · see citing works
Durie, B., Stock-Novack, D., Salmon, S., Finley, P. R., Beckord, J., Crowley, J. J., & Coltman, C. A. (1990) · Blood · doi:10.1182/blood.v75.4.823.823 · Cited by 186 · see citing works
Bataille, R., Durie, B. G. M., & Grenier, J. (1983) · British Journal of Haematology · doi:10.1111/j.1365-2141.1983.tb02158.x · Cited by 178 · see citing works
Prognostic factors and staging in multiple myeloma: a reappraisal.
Bataille, R., Durie, B. G. M., Grenier, J., & Sany, J. (1986) · Journal of Clinical Oncology · doi:10.1200/jco.1986.4.1.80 · Cited by 162 · see citing works
Peptide and beta 2-microglobulin regulation of cell surface MHC class I conformation and expression
Otten, G. R., Bikoff, E. K., Ribaudo, R. K., Kozlowski, S., Margulies, D. H., & Germain, R. N. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.12.3723 · Cited by 125 · see citing works
Beta 2-microglobulin: its significance and clinical usefulness.
Bethea, M. C., & Forman, D. T. (1990) · PubMed · Cited by 117 · see citing works
ENDOGENOUS IFN-GAMMA DURING HUMAN BONE MARROW TRANSPLANTATION
Niederwieser, D. W., HEROLD, M., Woloszczuk, W., Aulitzky, W. E., Meister, B., Tilg, H., GASTL, G., Bowden, R., & HUBER, C. (1990) · Transplantation · doi:10.1097/00007890-199010000-00019 · Cited by 106 · see citing works
Österborg, A., Björkholm, M., Björeman, M., Brenning, G., Carlson, K. E., Celsing, F., Gahrton, G., Grimfors, G., Gyllenhammar, H., & Hast, R. (1993) · Blood · doi:10.1182/blood.v81.6.1428.1428 · Cited by 104 · see citing works
Prognostic Value of Serum β-2 Microglobulin in Low-Grade Lymphoma
Litam, P. P., Swan, F., Cabanillas, F., Tucker, S. L., McLaughlin, P. J., Hagemeister, F. B., Rodriguez, M. A., & Velasquez, W. S. (1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-114-10-855 · Cited by 100 · see citing works
Westin, J., Rödjer, S., Turesson, I., Cortelezzi, A., Hjorth, M., Zador, G., & for a Cooperative Study Group (1995) · British Journal of Haematology · doi:10.1111/j.1365-2141.1995.tb08364.x · Cited by 92 · see citing works
Cuzick, J. M., Cooper, E. H., & Maclennan, I. C. M. (1985) · British Journal of Cancer · doi:10.1038/bjc.1985.140 · Cited by 86 · see citing works
Garewal, H. S., Durie, B. G. M., Kyle, R. A., Finley, P. R., Bower, B., & Serokman, R. (1984) · Journal of Clinical Oncology · doi:10.1200/jco.1984.2.1.51 · Cited by 83 · see citing works
Beta‐2‐microglobulin review: Its relevance in clinical oncology
Cooper, E. H., & Plesner, T. (1980) · Medical and Pediatric Oncology · doi:10.1002/mpo.2950080403 · Cited by 77 · see citing works
β-2 microglobulin: a prognostic factor in diffuse aggressive non-Hodgkin's lymphomas
Johnson, P., Whelan, J. S., Longhurst, S., Stepniewska, K., Matthews, J., AMESS, J. A. L., Norton, A. J., Rohatiner, A., & Lister, T. A. (1993) · British Journal of Cancer · doi:10.1038/bjc.1993.144 · Cited by 54 · see citing works
The serum level and urinary excretion of beta2-microglobulin in health and renal disease.
Wibell, L. B. (1978) · PubMed · Cited by 49 · see citing works
Aulitzky, W. E., GROSSE-WILDE, H., WESTHOFF, U., TILG, H., AULITZKY, W., GASTL, G., HEROLD, M., & HUBER, C. (1991) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.1991.tb05802.x · Cited by 47 · see citing works
Hayata, T., Nakano, Y., Yoshizawa, K., Sodeyama, T., & Kiyosawa, K. (1991) · Hepatology · doi:10.1002/hep.1840130603 · Cited by 47 · see citing works
Plesner, T., & Bjerrum, O. J. (1980) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.1980.tb00243.x · Cited by 46 · see citing works
Kantarjian, H. M., Smith, T., Estey, E. H., Polyzos, A., O'Brien, S. M., Pierce, S. A., Beran, M., Feldman, E. J., & Keating, M. J. (1992) · The American Journal of Medicine · doi:10.1016/0002-9343(92)90191-d · Cited by 40 · see citing works
Hofmann, B., Bass, H. Z., Nishanian, P., Faisal, M., Figlin, R. A., Sarna, G. P., & Fahey, J. L. (1992) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.1992.tb06485.x · Cited by 40 · see citing works
β2-Microglobulin and the Major Histocompatibility Complex
Peterson, P. A., Rask, L., & Östberg, L. (1977) · Advances in cancer research · doi:10.1016/s0065-230x(08)61014-3 · Cited by 39 · see citing works
Sensitive inhibitory effect of interferon-alpha on M-protein secretion of human myeloma cells
Tanaka, H., Tanabe, O., Iwato, K., Asaoku, H., Ishikawa, H., Nobuyoshi, M., Kawano, M., & Kuramoto, A. (1989) · Blood · doi:10.1182/blood.v74.5.1718.1718 · Cited by 37 · see citing works
Prognostic significance of pretreatment serum β2-microglobulin levels in multiple myeloma
Scarffe, J. H., Anderson, H., Palmer, M. K., & Crowther, D. (1983) · European Journal of Cancer and Clinical Oncology · doi:10.1016/0277-5379(93)90004-o · Cited by 34 · see citing works
Low-grade lymphoma 1993: State of the art
Horning, S. J. (1994) · Annals of Oncology · doi:10.1093/annonc/5.suppl_2.s23 · Cited by 30 · see citing works
Schiller, J. H., Hank, J. A., Storer, B. E., Borchert, A., Moore, K. H., Albertini, M. R., Bechhofer, R., Wesley, O., Brown, R. R., & Bastin, A. M. (1993) · PubMed · Cited by 29 · see citing works
Nachbaur, K., Troppmair, J., Kotlán, B., König, P., Aulitzky, W. E., Bieling, P., & Huber, C. (1988) · Immunobiology · doi:10.1016/s0171-2985(88)80092-5 · Cited by 28 · see citing works
Serum Beta2‐Microglobulin in Acute and Chronic Leukaemia
Ellegaard, J., Mogensen, C. E., & Kragballe, K. (1981) · Scandinavian Journal of Haematology · doi:10.1111/j.1600-0609.1981.tb01401.x · Cited by 28 · see citing works
Fuchs, D., Norkrans, G., Wejstål, R., Reibnegger, G. J., Weiss, G., Weiland, O., Schvarcz, R., Frydén, A., & WACHTER, H. (1992) · PubMed · Cited by 26 · see citing works
Schiller, J. H., Storer, B. E., Paulnock, D. M., Brown, R. R., Datta, S. P., Witt, P. L., & Borden, E. C. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114827 · Cited by 26 · see citing works
β2-microglobulin in urine and serum determined by ELIS A technique
Hemmingsen, L., & SKAARUP, P. (1985) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365518509161020 · Cited by 25 · see citing works
Beta 2 Microglobulin Level as an Indicator of Prognosis in Diffuse Large Cell Lymphoma
Avilés, A., Zepeda, G., Díaz‐Maqueo, J. C., Rodriguez, L., Guzmán, R., García, E. L., & Talavera, A. (1992) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428199209053613 · Cited by 25 · see citing works
Attal, M., Huguet, F., Schlaifer, D., Payen, C., Lassoued, S., Laroche, M., Rossi, J., Fournié, B., Mazières, B., & Pris, J. (1991) · PubMed · Cited by 24 · see citing works
Wejstål, R., Norkrans, G., Weiland, O., Schvarcz, R., Fuchs, D., WACHTER, H., Frydén, A., & Glaumann, H. (1992) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.1992.tb02999.x · Cited by 22 · see citing works
Regular Review: Interferon for treatment: the dust settles
Galvani, D. W., Griffiths, S. D., & Cawley, J. C. (1988) · BMJ · doi:10.1136/bmj.296.6636.1554 · Cited by 22 · see citing works
Serum Beta2-Microglobulin in Malignant Lymphoproliferative Disorders
Melillo, L. M. A., Musto, P., Tomasi, P., Cascavilla, N., Bodenizza, C., Ladogana, S., & Carotenuto, M. (1988) · Tumori Journal · doi:10.1177/030089168807400202 · Cited by 19 · see citing works
Aulitzky, W. E., Peschel, C., Desprès, D., Aman, J., Trautman, P. A., Tilg, H., Rudolf, G., Hüttmann, H., Obermeier, J., Herold, M., et al. (1993) · Annals of Hematology · doi:10.1007/bf01715048 · Cited by 13 · see citing works
Determination of β2-Microglobulin in Serum by a Microparticle-Enhanced Nephelometric Immunoassay
Viedma, J. A., Pacheco, S., & Albaladejo, M. D. (1992) · Clinical Chemistry · doi:10.1093/clinchem/38.12.2464 · Cited by 10 · see citing works
Drews, J. (1990) · Springer eBooks · doi:10.1007/978-3-642-75561-3 · Cited by 9 · see citing works
Jones, R., Drexler, H. G., Gignac, S. M., Child, J. A., & Cs, S. (1990) · British Journal of Cancer · doi:10.1038/bjc.1990.153 · Cited by 8 · see citing works
de Wit, R., Bakker, P. J. M., Reiss, P., Hoek, F. J., Lange, J. M. A., Goudsmit, J., & Veenhof, K. H. N. (1990) · AIDS · doi:10.1097/00002030-199005000-00013 · Cited by 7 · see citing works
Evrin, P., Jansson, N. O., & Bergdahl, A. (1986) · Clinica Chimica Acta · doi:10.1016/0009-8981(86)90276-7 · Cited by 7 · see citing works
Alpha interferon raises serum beta‐2‐microglobulin in patients with multiple myeloma
Tienhaara, A., Remes, K., & Pelliniemi, T. (1991) · British Journal of Haematology · doi:10.1111/j.1365-2141.1991.tb08580.x · Cited by 7 · see citing works
Self-citationIFN-beta induced biochemical and immunological modifications in hairy cell leukemia patients.
Liberati, A. M., Schippa, M., Portuesi, M. G., Proietti, M. G., Angelis, V. D., Ferrajoli, A., Cinieri, S., Clemente, F., Palmisano, L., & Berruto, P. (1991) · PubMed · Cited by 6 · see citing works
Double monoclonal time-resolved immunofluorometric assay of beta 2-microglobulin in serum
Tienhaara, A., Eskola, J., & Näntö, V. (1990) · Clinical Chemistry · doi:10.1093/clinchem/36.11.1961 · Cited by 4 · see citing works
Self-citationAlpha interferon raises serum beta‐2‐microglobulin in patients treated for thrombocythaemia
Remes, K., Tienhaara, A., & Pelliniemi, T. (1993) · British Journal of Haematology · doi:10.1111/j.1365-2141.1993.tb03082.x · Cited by 2 · see citing works
Self-citationOpat, P., Drbal, J., Tauer, Z., & Wotke, R. (1988) · European Journal of Cancer and Clinical Oncology · doi:10.1016/0277-5379(88)90218-0 · Cited by 2 · see citing works
Demeter, J., Pálóczi, K., Bíbok, G., & Lehoczky, D. (1992) · PubMed · Cited by 2 · see citing works
Priming Therapy with Alpha-Interferon in Chemotherapy-Resistant Multiple Myeloma
Remes, K., Tienhaara, A., & Pelliniemi, T. (1992) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428199209064901 · Cited by 1 · see citing works
Self-citationPelosi, E., Testa, U., Gabbianelli, M., Valtieri, M., Montesoro, E., Samoggia, P., Mastroberardino, G., Isacchi, G., & Peschle, C. (1992) · PubMed · Cited by 1 · see citing works
Value of the serum beta-2-microglobulin/serum creatinine ratio following renal transplantation.
Wf, F., Ka, H., Dt, F., & Mandel, S. R. (1984) · PubMed · Cited by 1 · see citing works
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- Authors
- Remes, K., Tienhaara, A., & Pelliniemi, T.-T.
- Affiliations
- Turku University Hospital (FI)
- Venue
- Leukemia & Lymphoma
- Publisher
- Informa UK Limited
- Published
- 1996-01
- Volume
- 21
- Issue
- 3-4
- Pages
- 233-238
- ISSN
- 1026-8022 (ISSN-L)
- 1042-8194
- 1029-2403
- OpenAlex
- W2030520505
- Cited by
- 13
- References
- 59
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2018: 1 · 2017: 1 · 2012: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Leukemia & lymphoma/Leukemia and lymphoma (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Multiple Myeloma Research and Treatments
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
- Keywords
- interferon-alpha, beta2-microglobulin, serum biomarkers, multiple myeloma, myeloproliferative neoplasms, tumor burden monitoring, interferon therapy
- MeSH terms
- beta 2-Microglobulin, Humans, Multiple Myeloma, Myeloproliferative Disorders, Interferon-alpha
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