Associations Between Day-by-Day Variability in Blood Pressure Measured at Home and Antihypertensive Drugs: The J-HOME-Morning Study
Abstract
We identified the factors associated with home blood pressure (BP) variability in 1933 patients treated with hypertensive drugs (mean age, 67 years; women, 55%). Multivariate regression analysis showed that female gender, advanced age, home BP value, and home heart rate variability were positively associated with home BP variability, whereas home heart rate, body mass index, and duration of antihypertensive treatment were negatively associated with home BP variability. Moreover, not being medicated with amlodipine and being medicated with angiotensin II receptor blockers were associated with increased home systolic BP variability only among patients who were treated for less than 12 months.
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In elderly individuals, it may be difficult to use HBPM because of physical and/or cognitive dysfunction of the users.
“However, in the elderly individuals, it may be difficult to use HBPM because of physical and/or cognitive dysfunction of the users [242].”
Cites
Nissen, S. E., Tuzcu, E. M., Libby, P., Thompson, P. D., Ghali, M. G. H., Garza, D., Berman, L., Shi, H. H., Buebendorf, E., Topol, E. J., et al. (2004) · JAMA · doi:10.1001/jama.292.18.2217 · Cited by 1,145 · see citing works
Effects of age and aerobic capacity on arterial stiffness in healthy adults.
Vaitkevicius, P. V., Fleg, J. L., Engel, J.-H., O’Connor, F. C., Wright, J. G., Lakatta, L. E., Yin, F. C. P., & Lakatta, E. G. (1993) · Circulation · doi:10.1161/01.cir.88.4.1456 · Cited by 1,082 · see citing works
Webb, A. J., Fischer, U., Mehta, Z., & Rothwell, P. M. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60235-8 · Cited by 729 · see citing works
Prognostic Significance of Blood Pressure and Heart Rate Variabilities
Kikuya, M., Hozawa, A., Ohokubo, T., Tsuji, I., Michimata, M., Matsubara, M., Ota, M., Nagai, K., Araki, T., Satoh, H., et al. (2000) · Hypertension · doi:10.1161/01.hyp.36.5.901 · Cited by 609 · see citing works
Self-citationEuropean Society of Hypertension Practice Guidelines for home blood pressure monitoring
Parati, G., Stergiou, G. S., Asmar, R., Bilo, G., de Leeuw, P., Imai, Y., Kario, K., Lurbe, E., Manolis, A., Mengden, T., et al. (2010) · Journal of Human Hypertension · doi:10.1038/jhh.2010.54 · Cited by 482 · see citing works
Self-citationDay-by-Day Variability of Blood Pressure and Heart Rate at Home as a Novel Predictor of Prognosis
Kikuya, M., Ohkubo, T., Metoki, H., Asayama, K., Hara, A., Obara, T., Inoue, R., Hoshi, H., Hashimoto, J., Totsune, K., et al. (2008) · Hypertension · doi:10.1161/hypertensionaha.107.104620 · Cited by 400 · see citing works
Self-citationHodgkinson, J., Mant, J., Martin, U., Guo, B., Hobbs, F. D. R., Deeks, J. J., Heneghan, C., Roberts, N., & McManus, R. J. (2011) · BMJ · doi:10.1136/bmj.d3621 · Cited by 370 · see citing works
Jananese Society of Hypertension (JSH) Guidelines for Self-Monitoring of Blood Pressure at Home
Imai, Y., Otsuka, K., Kawano, Y., Shimada, K., HAYASHI, H., Tochikubo, O., Miyakawa, M., & Fukiyama, K. (2003) · Hypertension Research · doi:10.1291/hypres.26.771 · Cited by 307 · see citing works
Self-citationPapademetriou, V., Farsang, C., Elmfeldt, D., Albert Hofman, D., Lithell, H., Olofsson, B., Skoog, I. G., Trenkwalder, P., & Zanchetti, A. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.06.034 · Cited by 180 · see citing works
Enalapril and Losartan Reduce Sympathetic Hyperactivity in Patients with Chronic Renal Failure
Klein, I. H. H. T., Ligtenberg, G., Oey, P. L., Koomans, H. A., & Blankestijn, P. J. (2003) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000045049.72965.b7 · Cited by 150 · see citing works
Eguchi, K., Ishikawa, J., Hoshide, S., Pickering, T. G., Schwartz, J. E., Shimada, K., & Kario, K. (2008) · American Journal of Hypertension · doi:10.1038/ajh.2008.294 · Cited by 143 · see citing works
Naruse, M., Tanabe, A., Sato, A., Takagi, S., Tsuchiya, K., Imaki, T., & Takano, K. (2002) · Hypertension · doi:10.1161/01.hyp.0000022606.52221.2f · Cited by 129 · see citing works
Sympathetic overactivity as a cause of hypertension in chronic renal failure
Augustyniak, R. A., Tuncel, M., Zhang, W., Toto, R. D., & Victor, R. G. (2002) · Journal of Hypertension · doi:10.1097/00004872-200201000-00002 · Cited by 126 · see citing works
Ohlstein, E. H., Brooks, D. P., Feuerstein, G., & Ruffolo, R. R., Jr. (2008) · Pharmacology · doi:10.1159/000139534 · Cited by 117 · see citing works
Kizer, J. R., Dahlöf, B., Kjeldsen, S. E., Julius, S., Beevers, G., Fairé, U. D., Fyhrquist, F., Ibsen, H., Kristianson, K. J., Lederballe‐Pedersen, O., et al. (2004) · Hypertension · doi:10.1161/01.hyp.0000151324.05355.1c · Cited by 99 · see citing works
Hara, A., Ohkubo, T., Kikuya, M., Shintani, Y., Obara, T., Metoki, H., Inoue, R., Asayama, K., Hashimoto, T., Harasawa, T., et al. (2007) · Journal of Hypertension · doi:10.1097/hjh.0b013e3280115bbf · Cited by 95 · see citing works
Self-citationUshigome, E., Fukui, M., Hamaguchi, M., Senmaru, T., Sakabe, K., Tanaka, M., Yamazaki, M., Hasegawa, G., & Nakamura, N. (2011) · Hypertension Research · doi:10.1038/hr.2011.128 · Cited by 83 · see citing works
Hamada, T., Watanabe, M., Kaneda, T., Ohtahara, A., Kinugawa, T., Hisatome, I., Fujimoto, Y., Yoshida, A., & Shigemasa, C. (1998) · Journal of Hypertension · doi:10.1097/00004872-199816010-00016 · Cited by 67 · see citing works
Mitsuhashi, H., Tamura, K., Yamauchi, J., Ozawa, M., Yanagi, M., Dejima, T., Wakui, H., Masuda, S., Azuma, K., Kanaoka, T., et al. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2009.04.005 · Cited by 63 · see citing works
Kato, T., Kikuya, M., Ohkubo, T., Satoh, M., Hara, A., Obara, T., Metoki, H., Asayama, K., Hirose, T., Inoue, R., et al. (2010) · American Journal of Hypertension · doi:10.1038/ajh.2010.94 · Cited by 62 · see citing works
Self-citationShirasaki, O., Terada, H., Niwano, K., Nakanishi, T., Kanai, M., Miyawaki, Y., Souma, T., Tanaka, T., & Kusunoki, T. (2001) · Blood Pressure Monitoring · doi:10.1097/00126097-200112000-00007 · Cited by 59 · see citing works
Johansson, J. K., Niiranen, T., Puukka, P. J., & Jula, A. (2010) · Journal of Hypertension · doi:10.1097/hjh.0b013e32833b6c8a · Cited by 47 · see citing works
Pickering, T. G., & James, G. D. (1989) · PubMed · Cited by 47 · see citing works
Masuda, S., Tamura, K., Wakui, H., Kanaoka, T., Ohsawa, M., Maeda, A., Dejima, T., Yanagi, M., Azuma, K., & Umemura, S. (2009) · Hypertension Research · doi:10.1038/hr.2009.131 · Cited by 46 · see citing works
Shigenaga, A.-I., Tamura, K., Dejima, T., Ozawa, M., Wakui, H., Masuda, S., Azuma, K., Tsurumi‐Ikeya, Y., Mitsuhashi, H., Okano, Y., et al. (2009) · Nephron Clinical Practice · doi:10.1159/000210572 · Cited by 44 · see citing works
Tamura, K., Tsurumi, Y., Sakai, M., Tanaka, Y., Okano, Y., Yamauchi, J., Ishigami, T., Kihara, M., Hirawa, N., Toya, Y., et al. (2006) · Clinical and Experimental Hypertension · doi:10.1080/10641960601096760 · Cited by 39 · see citing works
Stornello, M., Valvo, E. V., Vasques, E., Leone, S., & Scapellato, L. (1989) · Journal of Hypertension · doi:10.1097/00004872-198909007-00016 · Cited by 26 · see citing works
Kita, T., Suzuki, Y., Eto, T., & Kitamura, K. (2005) · Hypertension Research · doi:10.1291/hypres.28.959 · Cited by 22 · see citing works
Sympatho-inhibitory properties of various AT1 receptor antagonists.
Balt, J. C., Mathy, M. J., Pfaffendorf, M., & Vanzwieten, P. (2002) · PubMed · Cited by 17 · see citing works
Tamura, K., Azushima, K., & Umemura, S. (2011) · Hypertension Research · doi:10.1038/hr.2011.149 · Cited by 12 · see citing works
Kanaoka, T., Tamura, K., Moriya, T., Tanaka, K., Konno, Y., Kondoh, S., Toyoda, M., Umezono, T., Fujikawa, T., Ohsawa, M., et al. (2011) · Clinical and Experimental Hypertension · doi:10.3109/10641963.2011.583971 · Cited by 11 · see citing works
Ohno, Y., Kanno, Y., Maruyama, T., Morii, T., Eguchi, T., Hirao, K., Takenaka, T., & Suzuki, H. (2007) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1002278 · Cited by 7 · see citing works
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on behalf of the J-HOME-Morning Study group, Ishikura, K., Obara, T., Kikuya, M., Satoh, M., Hosaka, M., Metoki, H., Nishigori, H., Mano, N., Nakayama, M., et al. (2015) · Hypertension Research · doi:10.1038/hr.2015.110 · Cited by 10 · see citing works
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- Authors
- Ishikura, K., Obara, T., Kato, T., Kikuya, M., Shibamiya, T., Shinki, T., Ikeda, U., Kobayashi, Y., Metoki, H., Mano, N., Kuriyama, S., Ohkubo, T., Imai, Y., & the J-HOME-Morning Study Group
- Affiliations
- Tohoku University (JP)
- Tohoku University Hospital (JP)
- Shiga University of Medical Science (JP)
- Corresponding author
- Obara, Taku
- ORCID
- Venue
- Clinical and Experimental Hypertension
- Publisher
- Informa UK Limited
- Published
- 2012-05-07
- Volume
- 34
- Issue
- 4
- Pages
- 297-304
- ISSN
- 0148-3927 (ISSN-L)
- 1064-1963
- 1525-6006
- OpenAlex
- W2126651229
- Cited by
- 35
- References
- 32
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2021: 2 · 2020: 1 · 2019: 4 · 2018: 2 · 2017: 2 · 2016: 5 · 2015: 6 · 2014: 5 · 2013: 3 · 2012: 1
- FWCI
- 3.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical and Experimental Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (24659012)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Keywords
- antihypertensive drugs, hypertension, heart rate variability, amlodipine, angiotensin receptor blockers, body mass index, sex differences, age
- MeSH terms
- Aged, Antihypertensive Agents, Blood Pressure, Cross-Sectional Studies, Female, Humans, Hypertension, Male, Middle Aged, Time Factors, Multivariate Analysis, Blood Pressure Monitoring, Ambulatory
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