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Continuous Monitoring of in Vztro Oxidation of Human Low Density Lipoprotein
Abstract
The kinetics of the oxidation of human low density lipoprotein (LDL) can be measured continuously by monitoring the change of the 234 nm diene absorption. The time-course shows three consecutive phases, a lag-phase during which the diene absorption increases only weakly, a propagation phase with a rapid increase of the diene absorption and finally a decomposition phase. The increase of the dienes is highly correlated with the increase of MDA or lipid hydroperoxides. The duration of the lag-phase is determined by the endogenous antioxidants contained in LDL (vitamin E, carotenoids, retinylstearate). Water-soluble antioxidants (ascorbic acid, urate) added in micromolar concentrations prolong the lag-phase in a concentration-dependent manner. The determination of the lag-phase is a convenient and objective procedure for determining the susceptibility of LDL from different donors towards oxidation as well as effects of pro- and antioxidants.
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Citations
Cited by
Reactive Oxygen Species and the Central Nervous System
Halliwell, B. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb10990.x · Cited by 2,947
Brown, B. G., Zhao, X.-Q., Chait, A., Fisher, L. D., Cheung, M. C., Morse, J. S., Dowdy, A. A., Marino, E. K., Bolson, E. L., Alaupovic, P., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa011090 · Cited by 1,979
Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine
Frankel, E. N., German, J. B., Kinsella, J. E., Parks, E., & Kanner, J. (1993) · The Lancet · doi:10.1016/0140-6736(93)90206-v · Cited by 1,647
Bugianesi, E., Gastaldelli, A., Vanni, E., Gambino, R., Cassader, M., Baldi, S., Ponti, V., Pagano, G., Ferrannini, E., & Rizzetto, M. (2005) · Diabetologia · doi:10.1007/s00125-005-1682-x · Cited by 770
Commentary: Vitamin C: Antioxidant or Pro-Oxidant In Vivo?
Halliwell, B. (1996) · Free Radical Research · doi:10.3109/10715769609149066 · Cited by 531
Metadata
- Authors
- Esterbauer, H., Striegl, G., Puhl, H., & Rotheneder, M.
- Venue
- Free Radical Research Communications
- Publisher
- Informa UK Limited
- Published
- 1989-01
- Volume
- 6
- Issue
- 1
- Pages
- 67-75
- ISSN
- 8755-0199 (ISSN-L)
- OpenAlex
- W2212323528
- Cited by
- 1,790
- References
- 0
- FWCI
- 24.41
- Type
- journal article
- Language
- en
- Open access
- closed
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- Esterbauer, H., Striegl, G., Puhl, H., & Rotheneder, M. (1989). Continuous Monitoring of in Vztro Oxidation of Human Low Density Lipoprotein. Free Radical Research Communications. https://doi.org/10.3109/10715768909073429
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
