Commentary: Vitamin C: Antioxidant or Pro-Oxidant In Vivo?

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Oxygen free radicals and iron in relation to biology and medicine: Some problems and concepts

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Ascorbate is an outstanding antioxidant in human blood plasma

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Continuous Monitoring ofin VztroOxidation of Human Low Density Lipoprotein

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The antioxidants of human extracellular fluids

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High stored iron levels are associated with excess risk of myocardial infarction in eastern Finnish men

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How to Characterize a Biological Antioxidant

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The relative contributions of vitamin E, urate, ascorbate and proteins to the total peroxyl radical-trapping antioxidant activity of human blood plasma

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Superoxide‐dependent formation of hydroxyl radicals in the presence of iron chelates

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The antioxidant role of vitamin C

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Inhibition of oxidation of methyl linoleate in solution by vitamin E and vitamin C.

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Commentary Oxidative Stress, Nutrition and Health. Experimental Strategies for Optimization of Nutritional Antioxidant Intake in Humans

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Oxidation of ascorbic acid with superoxide anion generated by the xanthine-xanthine oxidase system

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Antioxidant and pro-oxidant actions of the plant phenolics quercetin, gossypol and myricetin

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Dietary Carotenes, Vitamin C, and Vitamin E as Protective Antioxidants in Human Cancers

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Copper-ion-dependent damage to the bases in DNA in the presence of hydrogen peroxide

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Vitamin C and cancer prevention: the epidemiologic evidence

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Gas phase oxidants of cigarette smoke induce lipid peroxidation and changes in lipoprotein properties in human blood plasma. Protective effects of ascorbic acid

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Stimulation of lipid peroxidation and hydroxyl-radical generation by the contents of human atherosclerotic lesions

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Non‐Specific Serum Iron in Thalassaemia: an Abnormal Serum Iron Fraction of Potential Toxicity

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Non-transferrin-bound iron in plasma or serum from patients with idiopathic hemochromatosis

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The protection by ascorbate and glutathione against microsomal lipid peroxidation is dependent on vitamin E

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On the antioxidant effects of ascorbic acid and glutathione

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Ascorbate free radical as a marker of oxidative stress: An EPR study

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The orthomolecular treatment of cancer II. Clinical trial of high-dose ascorbic acid supplements in advanced human cancer

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Antioxidant protection against hypochlorous acid in human plasma.

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Body iron stores and risk of cancer

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Oxidants, antioxidants, and respiratory tract lining fluids.

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A Prospective Study of the Intake of Vitamins C, E, and A and the Risk of Breast Cancer

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Increased risk of cardiovascular disease at suboptimal plasma concentrations of essential antioxidants: an epidemiological update with special attention to carotene and vitamin C

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Paradoxical Behavior of Antioxidants in Food and Biological Systems

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Modification of plasma proteins by cigarette smoke as measured by protein carbonyl formation

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Lipid peroxide formation in microsomes. The role of non-haem iron

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Ascorbic acid oxidation product(s) protect human low density lipoprotein against atherogenic modification. Anti- rather than prooxidant activity of vitamin c in the presence of transition metal ions

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Low-molecular-weight iron complexes and oxygen radical reactions in idiopathic haemochromatosis

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SOME PROPERTIES OF THE ASCORBATE FREE RADICAL*

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Body Iron Stores and the Risk of Coronary Heart Disease

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Commentary the Measurement of Oxidative Damage to DNA by HPLC and GC/MS Techniques

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Kinetics and mechanism for the oxidation of ascorbic acid/ascorbate by HO2/O2- (hydroperoxyl/superoxide) radicals. A pulse radiolysis and stopped-flow photolysis study

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Antioxidant protection of phospholipid bilayers by alpha-tocopherol. Control of alpha-tocopherol status and lipid peroxidation by ascorbic acid and glutathione.

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Inhibition of mitochondrial respiration and production of toxic oxygen radicals by flavonoids

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Lipid peroxidation in rheumatoid arthritis: Thiobarbituric acid-reactive material and catalytic iron salts in synovial fluid from rheumatoid patients

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Superoxide‐dependent formation of hydroxyl radicals in the presence of thiol compounds

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Copper and iron are mobilized following myocardial ischemia: possible predictive criteria for tissue injury.

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Pharmacology of Vitamin C

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Lower levels of vitamin C and carotenes in plasma of cigarette smokers.

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Millimolar concentrations of ascorbic acid in purified human mononuclear leukocytes. Depletion and reaccumulation.

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Ascorbic acid, metal ions and the superoxide radical

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Biokinetics of dietaryRRR‐α‐tocopherol in the male guinea pig at three dietary levels of vitamin C and two levels of vitamin E. Evidence that vitamin C does not “spare” vitamin Ein vivo

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Biologically significant scavenging of the myeloperoxidase‐derived oxidant hypochlorous acid by ascorbic acid

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Effects of Glutathione and Chelating Agents on Copper-Mediated DNA Oxidation: Pro-oxidant and Antioxidant Properties of Glutathione

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Iron Overload Augments the Development of Atherosclerotic Lesions in Rabbits

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Low iron-binding capacity as a risk factor for myocardial infarction.

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Prevalence of haemochromatosis amongst asymptomatic Australians

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Serum Copper and the Risk of Acute Myocardial Infarction: A Prospective Population Study in Men in Eastern Finland

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The antioxidant efficiency of vitamin C is concentration-dependent

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Ascorbate Autoxidation in the Presence of Iron and Copper Chelates

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Protection Against Peroxynitrite-Dependent Tyrosine Nitration and α1-Antiproteinase Inactivation by Ascorbic Acid. A Comparison with other Biological Antioxidants

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Vitamin C and Iron

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Ten-year retrospective on the antioxidant hypothesis of arteriosclerosis: Threshold plasma levels of antioxidant micronutrients related to minimum cardiovascular risk

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Genetic toxicology of ascorbic acid

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Iron overload cardiomyopathies: New insights into an old disease

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The health effects of vitamin C supplementation: A review

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Kinetics and mechanism for the oxidation of ascorbic acid/ascorbate by HO_2/O_2-radicals. A pulse radiolysis and stopped-flow photolysis study.

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Antioxidant protection against organic and inorganic oxygen radicals by normal human plasma: the important primary role for iron-binding and iron-oxidising proteins

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The production of reactive oxygen species by dietary flavonols

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The determination of dehydroascorbic acid and ascorbic acid in the serum and synovial fluid of patients with rheumatoid arthritis (RA).

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Immunocompetence and oxidant defense during ascorbate depletion of healthy men

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Interaction of nitrogen dioxide with human plasma Antioxidant depletion and oxidative damage

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Prooxidant iron and copper, with ferroxidase and xanthine oxidase activities in human atherosclerotic material

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[15] Sulfur-centered free radicals

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The effect of high ascorbic acid supplementation on body iron stores

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L-ascorbic acid quenching of singlet delta molecular oxygen in aqueous media: Generalized antioxidant property of vitamin C

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Ascorbic Acid-Induced Hemolysis in G-6-PD Deficiency

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Low vitamin E content in plasma of patients with alcoholic liver disease, hemochromatosis and wilson's disease

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Use of ascorbic acid to inhibit nitrosation: kinetic and mass transfer considerations for an in vitro system

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Stopped-flow kinetic study of vitamin E regeneration reaction with biological hydroquinones (reduced forms of ubiquinone, vitamin K, and tocopherolquinone) in solution.

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Reaction of Ascorbate with the α-Tocopheroxyl Radical in Micellar and Bilayer Membrane Systems

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Dehydroascorbate reduction

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Scavenging of superoxide radical by ascorbic acid

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Oxidative stress and abnormal cholesterol metabolism in patients with adult respiratory distress syndrome.

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Attenuation of 6-hydroxydopamine (6-OHDA)-induced nuclear factor-kappaB (NF-κB) activation and cell death by tea extracts in neuronal cultures11Abbreviations: BT, Black Tea; EMSA, Electromobility Shift Assay; EGCG, (-)-Epigallocatechin-3-gallate; GT, Green Tea; NB SH-SY5Y cells, Human neuroblastoma SH-SY5Y cells; 6-OHDA, 6-hydroxydopamine; IL, Interleukin; LDH, Lactate Dehydrogenase; MPTP, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; NF-κB, nuclear factor-κB; OS, Oxidative Stress; PD, Parkinson’s Disease; ROS, Reactive Oxygen Species; SNPC, Substantia Nigra Pars Compacta; TBARS, thiobarbituric acid reactive substances.

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The Effects of Iron and Vitamin C Co-supplementation on Oxidative Damage to DNA in Healthy Volunteers

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Cellular pathways for transport and efflux of ascorbate and dehydroascorbate

Corti, A., Casini, A. F., & Pompella, A. (2010) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2010.05.014 · Cited by 193 · see citing works

Myths, Artifacts, and Fatal Flaws: Identifying Limitations and Opportunities in Vitamin C Research

Michels, A., & Frei, B. (2013) · Nutrients · doi:10.3390/nu5125161 · Cited by 111 · see citing works

Common Presence of Non–Transferrin-Bound Iron Among Patients With Type 2 Diabetes

Lee, D.-H., Liu, D. Y., Jacobs, D. R., Shin, H.-R., Song, K., Lee, I.-K., Kim, B., & Hider, R. C. (2006) · Diabetes Care · doi:10.2337/dc05-2471 · Cited by 128 · see citing works

Limited evidence for a beneficial effect of vitamin C supplementation on biomarkers of cardiovascular diseases: An umbrella review of systematic reviews and meta-analyses

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Iron and ascorbic acid concentrations in human dermis with regard to age and body sites.

Leveque, N., Robin, S., Makki, S., Muret, P., Rougier, A., & Humbert, P. (2003) · Gerontology · doi:10.1159/000067951 · Cited by 30 · see citing works

Do low molecular weight antioxidants contribute to the Protection against oxidative damage? The interrelation between oxidative stress and low molecular weight antioxidants based on data from the MARK-AGE study

Pinchuk, I., Kohen, R., Stuetz, W., Weber, D., Franceschi, C., Capri, M., Hurme, M., Grubeck-Loebenstein, B., Schön, C., Bernhardt, J., et al. (2021) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2021.109061 · Cited by 17 · see citing works

Antioxidant capacity of phytochemicals and their effects.

Srivastava, S. K. (2016) · Journal of Emerging Technologies and Innovative Research

Herbal antioxidant: Vitamin C

Kirtawade, R., Salve, P. L., Kulkarni, A. R., et al. (2010) · Research Journal of Pharmacy and Technology · Cited by 1 · see citing works

Vitamin C: Newer Insights into Its Biochemical Functions

Padh, H. (1991) · Nutrition Reviews · doi:10.1111/j.1753-4887.1991.tb07407.x · Cited by 233 · see citing works

Antioxidant Activity of Antioxidant Extract from Black Soybean Skin

Min-l, Y. (2013) · Academic Periodical of Farm Products Processing

Interaction of vitamin E and ascorbic acid (review).

Chen, L. H. (1992) · PubMed · Cited by 33 · see citing works