The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Superoxide-Dependent Formation of Hydroxyl Radicals from Ferric-Complexes and Hydrogen Peroxide: An Evaluation of Fourteen Iron Chelators
Abstract
When a variety of ferric chelates are reacted with hydrogen peroxide in phosphate buffer deoxyribose is damaged and this damage is protected against by formate, thiourea and mannitol. Damage done by ferric complexes of citrate, EDTA, NTA, EGTA and HEDA is substantially inhibited by superoxide dismutase (SOD) whereas complexes of PLA, ADP and CDTA are moderately inhibited by SOD. The effects of SOD argue against hydrogen peroxide acting as a reductant in Fenton chemistry driven by ferric complexes and hydrogen peroxide. EDTA has proved to be a useful model for Fenton chemistry that is inhibited by SOD although, it is not unique in this respect.
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Mitochondrial DNA is a sensitive target of excess ROS, subject to an oxidation rate 10- to 20-fold higher than that of nuclear DNA.
“A sensitive target of excess ROS is mitochondrial DNA (Fig. 22), which is subject to an oxidation rate 10- to 20-fold higher than that of nuclear DNA (140, 142, 262).”
From Mitochondrial reactive oxygen species production in excitable cells: Modulators of mitochondrial and cell function (2009) · cites this paper as [140]
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Cites
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Self-citationSuperoxide‐dependent production of hydroxyl radical catalyzed by iron—EDTA complex
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Formation of a thiobarbituric‐acid‐reactive substance from deoxyribose in the presence of iron salts
Halliwell, B. B., & Gutteridge, J. M. C. (1981) · FEBS Letters · doi:10.1016/0014-5793(81)80114-7 · Cited by 832
Self-citationSuperoxide‐dependent formation of hydroxyl radicals in the presence of iron chelates
Halliwell, B. B. (1978) · FEBS Letters · doi:10.1016/0014-5793(78)80779-0 · Cited by 743
Gutteridge, J. M. C. (1981) · FEBS Letters · doi:10.1016/0014-5793(81)80113-5 · Cited by 284
Self-citationGutteridge, J. M. C. (1987) · Biochemical Journal · doi:10.1042/bj2430709 · Cited by 271
Self-citationInorganic Free Radicals in Solution.
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Mannitol as an OH· Scavenger in Aqueous Solutions and in Biological Systems
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Superoxide dismutase inhibits the superoxide‐driven Fenton reaction at two different levels
Gutteridge, J. M. C. (1985) · FEBS Letters · doi:10.1016/0014-5793(85)80732-8 · Cited by 117
Self-citationIron(III)-ethylenediaminetetraacetic acid-peroxide system
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Effect of thiourea on microsomal oxidation alcohols and associated microsomal functions
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Self-citationRedox potential of iron-bleomycin
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Stimulation of iron(II) bleomycin activity by phosphate-containing compounds
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Research works printed but not linked: 3
- Gutteridge J. M.C, 1990, Biochem. J.
- Bourne E. J., 1959, Chem. Ind. (London), 998
- Elgavish G. A., 1979, J. Mag. Reson., 36, 147
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Role of iron in carcinogenesis: cancer as a ferrotoxic disease
Toyokuni, S. (2009) · Cancer Science · doi:10.1111/j.1349-7006.2008.01001.x · Cited by 552
Stowe, D. F., & Camara, A. K. S. (2009) · Antioxidants & Redox Signaling · doi:10.1089/ars.2008.2331 · Cited by 471
Krishna, C. M., Liebmann, J. E., Kaufman, D., DeGraff, W., Hahn, S. M., McMurry, T., Mitchell, J. B., & Russo, A. (1992) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(92)90142-j · Cited by 110
Metadata
- Authors
- Gutteridge, J. M. C.
- Affiliations
- Oklahoma Medical Research Foundation (US)
- Corresponding author
- Gutteridge, John M.C.
- Venue
- Free Radical Research Communications
- Publisher
- Informa UK Limited
- Published
- 1990-01
- Volume
- 9
- Issue
- 2
- Pages
- 119-125
- ISSN
- 8755-0199 (ISSN-L)
- OpenAlex
- W2043759255
- Cited by
- 71
- References
- 18
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 1
- FWCI
- 4.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Free Radical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Inorganic Chemistry › Metal-Catalyzed Oxygenation Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Physical Sciences › Chemistry › Organic Chemistry › Free Radicals and Antioxidants
- Keywords
- Fenton reaction, hydroxyl radicals, superoxide, iron(III) complexes, iron chelators, hydrogen peroxide, superoxide dismutase, deoxyribose oxidation, DNA damage, EDTA, citrate, NTA, EGTA, polylactic acid, ADP, CDTA, formate, thiourea, mannitol
- MeSH terms
- Chemistry, Citrates, Deoxyribose, Edetic Acid, Hydrogen Peroxide, Hydroxides, Iron Chelating Agents, Nitrilotriacetic Acid, Superoxides, Hydroxyl Radical, Citric Acid, Chemical Phenomena
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