Formulation and evaluation of metformin hydrochloride-loaded niosomes as controlled release drug delivery system

Hasan, Azza A.; Madkor, Hafez; Wageh, Sherief

doi:10.3109/10717544.2013.779332

Cited by 122Advanced Drug Delivery SystemsDrug Solubulity and Delivery SystemsNanoparticle-Based Drug Delivery

Formulation and evaluation of metformin hydrochloride-loaded niosomes as controlled release drug delivery system

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Hasan, Azza A., Madkor, Hafez, Wageh, Sherief·2013·Drug Delivery

DOI 10.3109/10717544.2013.779332

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Abstract

Lactic acidosis is a serious, metabolic complication that may occur due to metformin hydrochloride (MH) accumulation during the treatment of diabetes mellitus. The aim of this study is to enhance the bioavailability of MH by oral route. Span 40 and cholesterol were used for the preparation of MH-loaded niosomes by the reverse phase evaporation technique. Dicetyl phosphate (DCP) and 1,2-dioleoyl-3-trimethylammonium-propane chloride salt (DOTAP) were used to obtain negatively and positively charged vesicles, respectively. The mean particle size ranged from 223.5 to 384.6 nm and the MH-loaded niosomes' surface was negatively charged in the absence of charge inducing agents (-16.6 ± 1.4 mV) and also with DCP (-26.9 ± 1.0 mV), while it was positively charged (+8.7 ± 1.2 mV) with DOTAP. High entrapment efficiency was observed in all the formulations. MH-loaded niosomes were found to effectively sustain the release of drug, particularly with positively charged niosomes. The bioavailability of MH-loaded niosomes was assessed by measuring the serum values of glucose and metformin in the different studied Wistar rats groups. The pharmacokinetic data of MH-loaded niosomal preparation showed a significant prolongation and increased intensity of hypoglycemic effect more than that observed for free MH solution. Area above the blood glucose levels-time curve (AAC), maximum hypoglycemic response and time of maximum response (T(max)) were significantly higher (p < 0.001) when MH was administered in niosomal form compared to free drug solution. It could be concluded that MH-loaded niosome is promising extended-release preparation with better hypoglycemic efficiency.

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Metformin-loaded niosomes have better efficacy than pure metformin in reducing blood glucose levels.
“Pharmacokinetic testing confirmed the better efficacy of metformin-loaded niosomes over pure metformin in reducing blood glucose levels.84”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [84]

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Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)
(1998) · The Lancet · doi:10.1016/s0140-6736(98)07037-8 · Cited by 8,247 · see citing works
Determination of Glucose in Blood Using Glucose Oxidase with an Alternative Oxygen Acceptor
Trinder, P. (1969) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/000456326900600108 · Cited by 4,629 · see citing works
Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group.
(1998) · PubMed · Cited by 4,290 · see citing works
Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain
OWEN, M. R., DORAN, E., & HALESTRAP, A. P. (2000) · Biochemical Journal · doi:10.1042/bj3480607 · Cited by 2,157 · see citing works
Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I
El-Mir, M.-Y., Nogueira, V., Fontaine, E., Avéret, N., Rigoulet, M., & Leverve, X. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.1.223 · Cited by 1,399 · see citing works
Phase transitions in phospholipid vesicles Fluorescence polarization and permeability measurements concerning the effect of temperature and cholesterol
Papahadjopoulos, D., Jacobson, K., Nir, S., & Isac, I. (1973) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(73)90314-3 · Cited by 998 · see citing works
Studies on lecithin-cholesterol-water interactions by differential scanning calorimetry and X-ray diffraction
Ladbrooke, B. D., Williams, R. M., & Chapman, D. (1968) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(68)90132-6 · Cited by 890 · see citing works
Clinical Pharmacokinetics of Metformin
Scheen, A. J. (1996) · Clinical Pharmacokinetics · doi:10.2165/00003088-199630050-00003 · Cited by 640 · see citing works
Niosome: A future of targeted drug delivery systems
Kuotsu, K., Karim, K. M., Mandal, A. S., Biswas, N., Guha, A., Chatterjee, S., & Behera, M. (2010) · Journal of Advanced Pharmaceutical Technology amp Research · doi:10.4103/0110-5558.76435 · Cited by 627 · see citing works
Preparation and properties of vesicles (niosomes) of sorbitan monoesters (Span 20, 40, 60 and 80) and a sorbitan triester (Span 85)
YOSHIOKA, T., Sternberg, B., & Florence, A. T. (1994) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(94)90228-3 · Cited by 476 · see citing works
Effects of metformin and thiazolidinediones on suppression of hepatic glucose production and stimulation of glucose uptake in type 2 diabetes: a systematic review
Natali, A., & Ferrannini, E. (2006) · Diabetologia · doi:10.1007/s00125-006-0141-7 · Cited by 377 · see citing works
Studies on a high encapsulation of colchicine by a niosome system
Hao, Y., Zhao, F., Li, N., Yang, Y., & Li, K. (2002) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(02)00301-0 · Cited by 365 · see citing works
Preparation and evaluation of reverse-phase evaporation and multilamellar niosomes as ophthalmic carriers of acetazolamide
Guinedi, A. S., Mortada, N. D., Mansour, S., & Hathout, R. M. (2005) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2005.09.023 · Cited by 356 · see citing works
Applications of nanotechnology to biotechnology
West, J. L., & Halas, N. J. (2000) · Current Opinion in Biotechnology · doi:10.1016/s0958-1669(00)00082-3 · Cited by 343 · see citing works
Effect of liposomes and niosomes on skin permeation of enoxacin
Fang, J., Hong, C.-T., Chiu, W., & Wang, Y.-Y. (2001) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(01)00627-5 · Cited by 310 · see citing works
In vitro study of polyoxyethylene alkyl ether niosomes for delivery of insulin
Pardakhty, A., Varshosaz, J., & Rouholamini, A. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2006.08.002 · Cited by 292 · see citing works
International Textbook of Diabetes Mellitus
DeCherney, G. S. (1993) · JAMA · doi:10.1001/jama.1993.03510150107047 · Cited by 285 · see citing works
Effect of Charged and Non-ionic Membrane Additives on Physicochemical Properties and Stability of Niosomes
Junyaprasert, V. B., Teeranachaideekul, V., & Supaperm, T. (2008) · AAPS PharmSciTech · doi:10.1208/s12249-008-9121-1 · Cited by 231 · see citing works
Role of Nanotechnology in Pharmaceutical Product Development
Devalapally, H., Chakilam, A. R., & Amiji, M. M. (2007) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.20875 · Cited by 231 · see citing works
Thiolated chitosans: development and in vitro evaluation of a mucoadhesive, permeation enhancing oral drug delivery system
Bernkop‐Schnürch, A., Guggi, D., & Pinter, Y. (2003) · Journal of Controlled Release · doi:10.1016/j.jconrel.2003.10.005 · Cited by 221 · see citing works
Niosomes as carriers for tretinoin. I. Preparation and properties
Manconi, M., Sinico, C., Valenti, D., Loy, G., & Fadda, A. M. (2002) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(01)00971-1 · Cited by 208 · see citing works
Effect of formulation and processing variables on the particle size of sorbitan monopalmitate niosomes
Essa, E. A. (2010) · Asian Journal of Pharmaceutics · doi:10.4103/0973-8398.76752 · Cited by 147 · see citing works
Metformin in the digestive tract
Vidon, N., Chaussade, S., Noël, M., Franchisseur, C., Huchet, B., & Bernier, J. J. (1988) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(88)80022-6 · Cited by 117 · see citing works
Sustained-release matrix tablets of metformin hydrochloride in combination with triacetyl-β-cyclodextrin
Corti, G., Cirri, M., Maestrelli, F., Mennini, N., & Mura, P. (2007) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2007.06.004 · Cited by 114 · see citing works
Preparation and evaluation of acetazolamide liposomes as an ocular delivery system
El-Gazayerly, O. N., & Hikal, A. H. (1997) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(97)00186-5 · Cited by 113 · see citing works
Preparation and properties of new unilamellar non-ionic/ionic surfactant vesicles
Carafa, M., Santucci, E., Alhaique, F., Coviello, T., Murtas, E., Riccieri, F. M., Lucania, G., & Torrisi, M. R. (1998) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(97)00294-9 · Cited by 111 · see citing works
Drug encapsulation and release from multilamellar and unilamellar liposomes
Betageri, G. V., & Parsons, D. L. (1992) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(92)90015-t · Cited by 100 · see citing works
PEGylated synthetic surfactant vesicles (Niosomes): novel carriers for oligonucleotides
Huang, Y., Chen, J., Chen, X., Gao, J., & Liang, W. (2007) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-007-3193-4 · Cited by 91 · see citing works
Preparation and Characterization of Nonionic Surfactant Vesicles
van Hal, D. A., Bouwstra, J. A., van Rensen, A., Jeremiasse, E., de Vringer, T., & Junginger, H. E. (1996) · Journal of Colloid and Interface Science · doi:10.1006/jcis.1996.0114 · Cited by 90 · see citing works
Effect of formulation and processing variables on the particle size of sorbitan monopalmitate niosomes
Essa, E. A. (2010) · Asian Journal of Pharmaceutics · doi:10.22377/ajp.v4i4.289 · Cited by 77 · see citing works
Discoidal niosome based controlled ocular delivery of timolol maleate.
Vyas, S. P., Mysore, N., Jaitely, V., & Venkatesan, N. (1998) · PubMed · Cited by 76 · see citing works
PREPARATION AND EVALUATION OF NIOSOMES CONTAINING ACECLOFENAC
Srinivas, S. P., & Kumar, Y. (2010) · Cited by 58 · see citing works
Occult Metformin Toxicity in Three Patients with Profound Lactic Acidosis
Perrone, J., Phillips, C., & Gaieski, D. F. (2008) · Journal of Emergency Medicine · doi:10.1016/j.jemermed.2007.11.055 · Cited by 52 · see citing works
METFORMIN AND LACTIC ACIDOSIS
Lebacq, E., & Tirzmalis, A. (1972) · The Lancet · doi:10.1016/s0140-6736(72)90311-x · Cited by 40 · see citing works
Investigation of PEG 6000/Tween 80/Span 80/H2O niosome microstructure
Liu, T., & Guo, R. H. (2007) · Colloid & Polymer Science · doi:10.1007/s00396-006-1627-z · Cited by 24 · see citing works
Protective role of tetrahydrocurcumin on changes in the fatty acid composition in streptozotocin-nicotinamide induced type 2 diabetic rats
Murugan, P., & Pari, L. (2007) · Journal of Applied Biomedicine · doi:10.32725/jab.2007.005 · Cited by 24 · see citing works
Niosomal Delivery Of Tenoxicam
Popli, H., & Nair, M. S. (1996) · Indian Journal of Pharmaceutical Sciences · Cited by 8 · see citing works
Formulation and Evaluation of Timolol Maleate Loaded Niosomes as an Ocular Drug Delivery System
Solyman, A. A. H. (2004) · Cited by 1 · see citing works

Flagged first, then by citations

1 of the 39 references couldn’t be matched to a known paper.

Sorted by citations

Type II diabetes mellitus: a review on recent drug based therapeutics.
Padhi, S., Nayak, A. K., & Behera, A. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110708 · Cited by 726 · see citing works
Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles
Singh, A. P., Biswas, A., Shukla, A., & Maiti, P. (2019) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-019-0068-3 · Cited by 645 · see citing works
Nanoparticle Delivery Systems in the Treatment of Diabetes Complications
Souto, E. B., Souto, S. B., Campos, J. R. S., Severino, P. B., Pashirova, T. N., Zakharova, L. Y., Silva, A. M., Durazzo, A., Lucarini, M., Izzo, A. A., et al. (2019) · Molecules · doi:10.3390/molecules24234209 · Cited by 245 · see citing works
Nanotechnology based approaches for anti-diabetic drugs delivery
Kesharwani, P., Gorain, B., Low, S. Y., Tan, S. A., Ling, E. C. S., Lim, Y. K., Chin, C. M., Lee, P. Y., Lee, C. M., Ooi, C. H., et al. (2017) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2017.11.018 · Cited by 200 · see citing works
In vitro release of metformin from iron (III) cross-linked alginate–carboxymethyl cellulose hydrogel beads
Swamy, B. Y., & Yun, Y. (2015) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2015.03.019 · Cited by 164 · see citing works
Niosomal carriers enhance oral bioavailability of carvedilol: effects of bile salt-enriched vesicles and carrier surface charge
Dadashzadeh, S., Haeri, A., Daeihamed, M., Arzani, G., & Kaboutaraki, H. B. (2015) · International Journal of Nanomedicine · doi:10.2147/ijn.s84703 · Cited by 126 · see citing works
Trends of nanotechnology in type 2 diabetes mellitus treatment
Simos, Y. V., Spyrou, K., Patila, M., Karouta, N., Stamatis, H., Gournis, D., Dounousi, E. C., & Peschos, D. (2020) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2020.05.001 · Cited by 112 · see citing works
Microparticulate and nanoparticulate drug delivery systems for metformin hydrochloride
Çetin, M., & Şahin, S. (2015) · Drug Delivery · doi:10.3109/10717544.2015.1089957 · Cited by 111 · see citing works
Novel drug delivery system: an immense hope for diabetics
Rai, V. K., Mishra, N., Agrawal, A. K., Jain, S., & Yadav, N. P. (2014) · Drug Delivery · doi:10.3109/10717544.2014.991001 · Cited by 102 · see citing works
Nanoparticulate-based drug delivery systems for small molecule anti-diabetic drugs: An emerging paradigm for effective therapy
Uppal, S., Italiya, K. S., Chitkara, D., & Mittal, A. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.09.049 · Cited by 98 · see citing works
Lipid-Based Nanovesicular Drug Delivery Systems
Limongi, T., Susa, F., Marini, M., Allione, M., Torre, B., Pisano, R., & Fabrizio, E. M. D. (2021) · Nanomaterials · doi:10.3390/nano11123391 · Cited by 87 · see citing works
Metformin-Encapsulated Liposome Delivery System: An Effective Treatment Approach against Breast Cancer
Shukla, S. K., Kulkarni, N. S., Chan, A., Parvathaneni, V., Farrales, P., Muth, A., & Gupta, V. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11110559 · Cited by 83 · see citing works
Hydrogen bonded niosomes for encapsulation and release of hydrophilic and hydrophobic anti-diabetic drugs: An efficient system for oral anti-diabetic formulation
Samed, N., Sharma, V., & Sundaramurthy, A. (2017) · Applied Surface Science · doi:10.1016/j.apsusc.2017.11.055 · Cited by 82 · see citing works
Therapeutic medications against diabetes: What we have and what we expect
Hu, C., & Jia, W. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.11.008 · Cited by 80 · see citing works
Niosome Preparation Techniques and Structure—An Illustrated Review
Mawazi, S. M., Ge, Y., & Widodo, R. T. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17010067 · Cited by 75 · see citing works
Emerging Treatment Strategies for Diabetes Mellitus and Associated Complications: An Update
Mishra, V. K., Nayak, P., Sharma, M., Albutti, A., Alwashmi, A. S. S., Aljasir, M. A., Alsowayeh, N., & Tambuwala, M. M. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13101568 · Cited by 71 · see citing works
Natamycin niosomes as a promising ocular nanosized delivery system with ketorolac tromethamine for dual effects for treatment of candida rabbit keratitis;in vitro/in vivoand histopathological studies
El-Nabarawi, M. A., Tag, R., Teaima, M. H. M., Abary, M. Y. S., El-Mofty, H. M., Khafagy, M. M., Lotfy, N. M., & Salah, M. (2019) · Drug Development and Industrial Pharmacy · doi:10.1080/03639045.2019.1579827 · Cited by 71 · see citing works
Calcium alginate microspheres containing metformin hydrochloride niosomes and chitosomes aimed for oral therapy of type 2 diabetes mellitus
Maestrelli, F., Mura, P., González-Rodrı́guez, M. L., Cózar-Bernal, M. J., Rabasco, A. M., Mannelli, L. D. C., & Ghelardini, C. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.07.083 · Cited by 68 · see citing works
Optimized Mucoadhesive Coated Niosomes as a Sustained Oral Delivery System of Famotidine
Khalifa, A.-Z. M., & Rasool, B. K. A. (2017) · AAPS PharmSciTech · doi:10.1208/s12249-017-0780-7 · Cited by 65 · see citing works
Optimization, physicochemical characterization, and antimicrobial activity of a novel simvastatin nano-niosomal gel against E. coli and S. aureus
Akbarzadeh, I., Keramati, M., Azadi, A., Afzali, E., Shahbazi, R., Chiani, M., Norouzian, D., & Bakhshandeh, H. (2020) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2020.105019 · Cited by 64 · see citing works
Formulation and optimization of long acting dual niosomes using Box-Behnken experimental design method for combinative delivery of Ethionamide and D-cycloserine in Tuberculosis treatment
Kulkarni, P., Rawtani, D., & Barot, T. D. (2019) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2019.01.004 · Cited by 63 · see citing works
Niosomes of active Fumaria officinalis phytochemicals: antidiabetic, antineuropathic, anti-inflammatory, and possible mechanisms of action
Raafat, K. M., & El‐Zahaby, S. A. (2020) · Chinese Medicine · doi:10.1186/s13020-020-00321-1 · Cited by 62 · see citing works
Release Studies on Ciprofloxacin Loaded Non-ionic Surfactant Vesicles.
Akbari, V., Abedi, D., Pardakhty, A., & Sadeghi‐Aliabadi, H. (2015) · Europe PMC (PubMed Central) · Cited by 62 · see citing works
Potentialities of nanomaterials for the management and treatment of metabolic syndrome: A new insight
Adetunji, C. O., Michael, O. S., Rathee, S., Singh, K. R., Ajayi, O. O., Adetunji, J. B., Ojha, A., Singh, J., & Singh, R. P. (2021) · Materials Today Advances · doi:10.1016/j.mtadv.2021.100198 · Cited by 60 · see citing works
Formulation, characterization, and evaluation of the anti-tumor activity of nanosized galangin loaded niosomes on chemically induced hepatocellular carcinoma in rats
Sabry, S. A., Ramadan, H. E., Elghany, M. A., Okda, T. M., & Hasan, A. A. (2020) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2020.102163 · Cited by 58 · see citing works
Self-citation
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Chung, B. L., Toth, M. J., Kamaly, N., Sei, Y. J., Becraft, J. R., Mulder, W. J. M., Fayad, Z. A., Farokhzad, O. C., Kim, Y., & Langer, R. (2015) · Nano Today · doi:10.1016/j.nantod.2015.11.009 · Cited by 58 · see citing works
Enhanced oral bioavailability and sustained delivery of glimepiride via niosomal encapsulation:in-vitrocharacterization andin-vivoevaluation
Mohsen, A. M., AbouSamra, M. M., & ElShebiney, S. A. (2017) · Drug Development and Industrial Pharmacy · doi:10.1080/03639045.2017.1310224 · Cited by 58 · see citing works
Sugar-based novel niosomal nanocarrier system for enhanced oral bioavailability of levofloxacin
Imran, M. A., Shah, M. R., Ullah, F., Ullah, S., Elhissi, A. M. A., Nawaz, W., Ahmad, F., Sadiq, A., & Ali, I. (2016) · Drug Delivery · doi:10.1080/10717544.2016.1214991 · Cited by 56 · see citing works
Formulation of novel niosomal repaglinide chewable tablets using coprocessed excipients: in vitro characterization, optimization and enhanced hypoglycemic activity in rats
Fouad, S. A., Teaima, M. H. M., Gebril, M. I., Abd-Allah, F. I., El-Nabarawi, M. A., & Elhabal, S. F. (2023) · Drug Delivery · doi:10.1080/10717544.2023.2181747 · Cited by 46 · see citing works
Metformin hydrochloride and wound healing: from nanoformulation to pharmacological evaluation
El-Ridy, M. S., Yehia, S. A., Elsayed, I., Younis, M. M., Abdel-Rahman, R. F., & El-Gamil, M. A. (2018) · Journal of Liposome Research · doi:10.1080/08982104.2018.1556291 · Cited by 45 · see citing works
Co-Delivery of Metformin Enhances the Antimultidrug Resistant Tumor Effect of Doxorubicin by Improving Hypoxic Tumor Microenvironment
Li, Y., Luo, J., Lin, M., Zhi, P., Guo, W.-W., Han, M. Y., You, J., & Gao, J. (2019) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.9b00199 · Cited by 45 · see citing works
Experimental study of flow structures near the merging point of two parallel plane jets using PIV and POD
Lee, S., & Hassan, Y. A. (2017) · International Journal of Heat and Mass Transfer · doi:10.1016/j.ijheatmasstransfer.2017.09.047 · Cited by 43 · see citing works
Cationically Modified Inhalable Nintedanib Niosomes: Enhancing Therapeutic Activity Against Non-Small-Cell Lung Cancer
Shukla, S. K., Nguyen, V., Goyal, M., & Gupta, V. (2022) · Nanomedicine · doi:10.2217/nnm-2022-0045 · Cited by 41 · see citing works
Potential enhancement of metformin hydrochloride in solidified reverse micellar solution-based PEGylated lipid nanoparticles targeting therapeutic efficacy in diabetes treatment
Kenechukwu, F. C., Nnamani, D. O., Duhu, J. C., Nmesirionye, B. U., Momoh, M. A., Akpa, P. A., & Attama, A. A. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e09099 · Cited by 40 · see citing works
Intravaginal administration of metformin hydrochloride loaded cationic niosomes amalgamated with thermosensitive gel for the treatment of polycystic ovary syndrome: In vitro and in vivo studies
Saini, N., Sodhi, R. K., Bajaj, L., Pandey, R. S., Jain, U. K., Katare, O. P., & Madan, J. (2016) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2016.04.016 · Cited by 39 · see citing works
A promising nystatin nanocapsular hydrogel as an antifungal polymeric carrier for the treatment of topical candidiasis
AbouSamra, M. M., Basha, M., Awad, G. E. A., & Mansy, S. S. (2018) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2018.12.014 · Cited by 39 · see citing works
Recent developments in nanoparticles for the treatment of diabetes
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Application of Nanoparticles: Diagnosis, Therapeutics, and Delivery of Insulin/Anti-Diabetic Drugs to Enhance the Therapeutic Efficacy of Diabetes Mellitus
Debele, T. A., & Park, Y. C. (2022) · Life · doi:10.3390/life12122078 · Cited by 34 · see citing works
Experimental investigation of aerodynamics and structure of a swirl-stabilized kerosene spray flame with laser diagnostics
Malbois, P., Salaün, E., Vandel, A., Godard, G., Cabot, G., Renou, B., Boukhalfa, A. M., & Grisch, F. (2019) · Combustion and Flame · doi:10.1016/j.combustflame.2019.03.041 · Cited by 32 · see citing works
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Mohsen, A. M. (2019) · Current Drug Targets · doi:10.2174/1389450120666190307101642 · Cited by 26 · see citing works
Fabricating niosomal-PEG nanoparticles co-loaded with metformin and silibinin for effective treatment of human lung cancer cells
Salmani-Javan, E., Jafari-Gharabaghlou, D., Bonabi, E., & Zarghami, N. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1193708 · Cited by 24 · see citing works
Characterization of insulin-loaded liposome using column-switching HPLC
Ohnishi, N., Tanaka, S., Tahara, K., & Takeuchi, H. (2015) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2014.12.056 · Cited by 24 · see citing works
Niosome-encapsulated Doxycycline Hyclate for Potentiation of Acne Therapy: Formulation and Characterization
Kashani-Asadi-Jafari, F., & Hadjizadeh, A. (2022) · Pharmaceutical Nanotechnology · doi:10.2174/2211738510666220224103406 · Cited by 23 · see citing works
Niosomal Delivery of Celecoxib and Metformin for Targeted Breast Cancer Treatment
Basheer, H. A., Alhusban, M. A., Alkilani, A. Z., Alshishani, A., Elsalem, L., & Afarinkia, K. (2023) · Cancers · doi:10.3390/cancers15205004 · Cited by 23 · see citing works
Metformin Loaded Casein Micelles for Sustained Delivery: Formulation, Characterization and In-vitro Evaluation
Raj, J., & Uppuluri, K. B. (2015) · Biomedical & Pharmacology Journal · doi:10.13005/bpj/585 · Cited by 23 · see citing works
Core–shell drug carriers: liposomes, polymersomes, and niosomes
Dan, N. R. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-46143-6.00002-6 · Cited by 21 · see citing works
Evaluating the impacts and benefits of sheldgeese on crop yields in the Pampas region of Argentina: A contribution for mitigating the conflicts with agriculture
Gorosábel, A., Pedrana, J., Bernad, L., Caballero, V. J., Muñoz, S. D., & Maceira, N. (2019) · Agriculture Ecosystems & Environment · doi:10.1016/j.agee.2019.04.002 · Cited by 21 · see citing works
Formulation and evaluation of Metformin Hydrochloride-loaded Curcumin–Lycopene Niosomes
Katrolia, A., Chauhan, S. B., & Shukla, V. K. (2019) · SN Applied Sciences · doi:10.1007/s42452-019-1768-6 · Cited by 20 · see citing works
Potential cardioprotective and anticancer effects of carvedilol either free or as loaded nanoparticles with or without doxorubicin in solid Ehrlich carcinoma-bearing mice
Zidan, A., Saadany, A. A. E., Maghraby, G. M. E., Abdin, A. A., & Hedya, S. E. (2023) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2023.116448 · Cited by 20 · see citing works
Novel Approaches for the Management of Type 2 Diabetes Mellitus: An Update
Kumar, A., Mazumder, R., Rani, A., Pandey, P., & Khurana, N. (2023) · Current Diabetes Reviews · doi:10.2174/0115733998261903230921102620 · Cited by 20 · see citing works
Self-assembly based aerosolized hyaluronic acid (HA) loaded niosomes for lung delivery: An in-vitro and in-vivo evaluation
Kulkarni, P., Rawtani, D., Rajpurohit, S., Vasvani, S., & Barot, T. D. (2022) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2022.103627 · Cited by 19 · see citing works
A POD-based reduced-order model for uncertainty analyses in shallow water flows
Zokagoa, J.-M., & Soulaïmani, A. (2018) · International journal of computational fluid dynamics · doi:10.1080/10618562.2018.1513496 · Cited by 19 · see citing works
Spectral, thermal and morphological characteristics of ultrasonically synthesized poly(anisidine- co -phenylenediamine)/bentonite nanocomposites: A potential anti-diabetic drug carrier
Verma, A., & Riaz, U. (2018) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2018.03.072 · Cited by 18 · see citing works
Exploring the use of niosomes in cosmetics for efficient dermal drug delivery
Abu‐Huwaij, R., Alkarawi, A., Salman, D., & Alkarawi, F. (2023) · Pharmaceutical Development and Technology · doi:10.1080/10837450.2023.2233613 · Cited by 17 · see citing works
Development and statistical optimization of chitosan and eudragit based gastroretentive controlled release multiparticulate system for bioavailability enhancement of metformin HCl
Sahu, A. K., & Verma, A. (2016) · Journal of Pharmaceutical Investigation · doi:10.1007/s40005-016-0229-0 · Cited by 17 · see citing works
Enhancement of the Anti-inflammatory Efficacy of Betamethasone Valerate via Niosomal Encapsulation
(2021) · Biointerface Research in Applied Chemistry · doi:10.33263/briac116.1464014660 · Cited by 17 · see citing works
Factors affecting the morphology of some organic and inorganic nanostructures for drug delivery: characterization, modifications, and toxicological perspectives
Raychaudhuri, R., Pandey, A., Hegde, A. R., Fayaz, S. M. A., Chellappan, D. K., Dua, K., & Mutalik, S. (2020) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2020.1819237 · Cited by 15 · see citing works
Potential Enhancement of Metformin Hydrochloride in Lipid Vesicles Targeting Therapeutic Efficacy in Diabetic Treatment
Ossai, E. C., Madueke, C. A., Amadi, E. B., Ogugofor, M. O., Momoh, A. M., Okpala, C. O. R., Anosike, C. A., & NJOKU, O. U. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22062852 · Cited by 15 · see citing works
Development and Characterization of Niosomal Gel System using Lallementia royaleana Benth. mucilage for the treatment of Rheumatoid Arthritis.
Bhardwaj, S., & Bhatia, S. (2020) · PubMed Central · doi:10.22037/ijpr.2020.112887.14003 · Cited by 14 · see citing works
Diabetic eye: associated diseases, drugs in clinic, and role of self-assembled carriers in topical treatment
Kattar, A., Concheiro, Á., & Alvarez‐Lorenzo, C. (2021) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2021.1953466 · Cited by 14 · see citing works
Vesicle-based drug carriers
Dan, N. R. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813627-0.00001-6 · Cited by 14 · see citing works
Biomimetic engineered nanocarriers inspired by viruses for oral-drug delivery
Zhang, J., Liu, X., Lin, J., Bao, X., Peng, J., Gong, Z., Luan, X., & Chen, Y. (2022) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2022.121979 · Cited by 13 · see citing works
Metformin Hydrochloride Loaded Mucoadhesive Microspheres and Nanoparticles for Anti-Hyperglycemic and Anticancer Effects Using Factorial Experimental Design
Kotha, A. A., Ahmad, S. U., Dewan, I., Bhuiyan, M. A., Rahman, F. I., Mohamed, I. N., & Reza, M. S. (2023) · Drug Design Development and Therapy · doi:10.2147/dddt.s432790 · Cited by 11 · see citing works
A comprehensive review on niosomes: novel manufacturing techniques, factors influencing formation, applications and recent advances
Arshad, N., Shaheen, F., Khan, I. N., Naeem, S., Riaz, M., Siddique, M. I., Ayesha, M., & Waqar, M. A. (2024) · International Journal of Polymeric Materials · doi:10.1080/00914037.2024.2426611 · Cited by 11 · see citing works
Novel greener approached synthesis of polyacrylic nanoparticles for therapy and care of gestational diabetes
Cheng, X., Xu, Y., Jia, Q., Guo, N., Wang, Z., & Wang, Y. (2020) · Drug Delivery · doi:10.1080/10717544.2020.1809555 · Cited by 11 · see citing works
Key Aspects in Nanotechnology and Drug Delivery
Arias, J. L. (2014) · CRC Press eBooks · doi:10.1201/b17271-2 · Cited by 11 · see citing works
NIOSOMES VERSUS PRONIOSOMES AS PROMISING DRUG DELIVERY SYSTEMS IN TREATMENT OF DIABETES MELLITUS
Teaima, M. H. M., Gebril, M. I., Abd-Allah, F. I., & El-Nabarawi, M. A. (2022) · International Journal of Applied Pharmaceutics · doi:10.22159/ijap.2022v14i5.44039 · Cited by 10 · see citing works
Transcending Traditional Treatment: The Therapeutical Potential of Nanovesicles for Transdermal Baclofen Delivery in Repeated Traumatic Brain Injury
Sheta, N. M., El-Gazar, A. A., Ragab, G. M., Essa, M. A., Abdel-Haleem, K. M., & El-Dahmy, R. M. (2024) · Advanced Pharmaceutical Bulletin · doi:10.34172/apb.2024.031 · Cited by 10 · see citing works
A de novo formulation of metformin using chitosan‐based nanomicelles for potential diabetes therapy
Abbasian, M., Bighlari, P., Mahmoodzadeh, F., Acar, M. H., & Jaymand, M. (2019) · Journal of Applied Polymer Science · doi:10.1002/app.48037 · Cited by 10 · see citing works
Optimized buccoadhesive repaglinide-loaded cubogel: In-vitro characterization and in-vivo hypoglycemic activity in a streptozotocin-induced diabetic rat model
Younes, N. F., Latif, R., Badawi, A. A. E.-L., & Hegazy, K. (2025) · International Journal of Pharmaceutics X · doi:10.1016/j.ijpx.2025.100357 · Cited by 9 · see citing works
Nanocarriers and Diabetes: New Vistas and the Way Ahead
Mishra, D. K., Gautam, R. K., Dixit, P. V., & Sharma, S. (2022) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201024666221227140728 · Cited by 9 · see citing works
Enhanced skin delivery of propranolol HCl using nonionic surfactant-based vesicles for topical treatment of infantile hemangioma
Abdel-Aziz, R. T. A., Aly, U. F., & Mady, F. M. (2020) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2020.102235 · Cited by 9 · see citing works
Organogel investigations as a floating oral system with depot property
Kadoori, Z. S., Mohamed, M. B. M., & Numan, N. A. M. (2022) · Al Mustansiriyah Journal of Pharmaceutical Sciences · doi:10.32947/ajps.v20i4.783 · Cited by 8 · see citing works
Preparation and characterisation of self-emulsifying drug delivery system (SEDDS) for enhancing oral bioavailability of metformin hydrochloride using hydrophobic ion pairing complexation
Rezvanjou, S. N., Niavand, M. R., Shayesteh, O. H., Yeganeh, E. M., Moghadam, D. A., Derakhshandeh, K., & Mahjub, R. (2023) · Journal of Microencapsulation · doi:10.1080/02652048.2023.2170488 · Cited by 8 · see citing works
Silybin-based herbal nanocarriers: an advancement in anticancer therapy
Shete, M. B., Deshpande, A. S., & Shende, P. K. (2022) · Materials Technology · doi:10.1080/10667857.2022.2081286 · Cited by 8 · see citing works
Therapeutic applications of nanomedicine in metabolic diseases by targeting the endothelium
Hou, L., Zhang, M., Liu, L., Zhong, Q., Xie, M., & Zhao, G. (2022) · QJM · doi:10.1093/qjmed/hcac210 · Cited by 7 · see citing works
Nanomedicine’s transformative impact on anti-diabetic drug discovery: an appraisal
Saini, K., & Sharma, S. (2023) · Journal of Nanoparticle Research · doi:10.1007/s11051-023-05870-8 · Cited by 7 · see citing works
Epigallocatechin-3-gallate loaded proliposomal vesicles for management of traumatic brain injury: In-vitro and in-vivo evaluation
Al‐Najjar, A. H., Khalifa, M. K. A., Amin, O. M., & Badawi, N. M. (2024) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2024.105745 · Cited by 7 · see citing works
Exploring Innovative Approaches in Type-2 Diabetes Management: A Comprehensive Review on Nano-carriers and Transdermal Drug Delivery
Chauhan, N., Kumar, M., Kumar, K., Chopra, S., & Bhatia, A. (2024) · Current Pharmaceutical Design · doi:10.2174/0113816128313325240513113840 · Cited by 7 · see citing works
Stable self-assembled oral metformin-bridged nanocochleates against hepatocellular carcinoma
El-Melegy, M. G., El-Kamel, A. H., Mehanna, R. A., Gaballah, A. H., & Eltaher, H. M. (2024) · Drug Delivery and Translational Research · doi:10.1007/s13346-024-01724-5 · Cited by 7 · see citing works
Fingolimod loaded niosomes attenuates sevoflurane induced cognitive impairments
Weng, H., Liu, X., Ren, Y., Li, Y., & Li, X. (2021) · Biomedical Microdevices · doi:10.1007/s10544-021-00603-x · Cited by 7 · see citing works
Nanotechnology: Antidiabetics, Antioxidant and Anti-inflammatory
Samrat, K., Murthy, T. P. K., Divyashri, G., Krishna, R. H., & Chandraprabha, M. N. (2023) · Springer eBooks · doi:10.1007/978-981-99-1635-1_8 · Cited by 6 · see citing works
RECENT ADVANCES IN TREATMENT APPROACHES FOR DIABETES MELLITUS AND RELATED COMPLICATIONS: A REVIEW
Dhyani, S., Butola, M., Sautha, V., & Jakhmola, V. (2025) · International Journal of Applied Pharmaceutics · doi:10.22159/ijap.2025v17i2.53184 · Cited by 5 · see citing works
Potential Nanomaterials for the Treatment and Management of Diabetes Mellitus
Tiwari, S. S., & Wadher, S. J. (2023) · Springer eBooks · doi:10.1007/978-981-99-1635-1_11 · Cited by 5 · see citing works
Synthesis, structural characterization, cytotoxicity and encapsulation studies of N , N ʹ-(1, 2-dicyano-1,2-vinylene)- bis (4-hydroxysalicylideneaminato) di( p -chlorobenzyl)tin as potential anticancer drug
Amin, N. A. B. M., Hussen, R. S. D., Lee, S. M., Sim, K. S., & Navanesan, S. (2019) · Main Group Metal Chemistry · doi:10.1515/mgmc-2019-0010 · Cited by 5 · see citing works
Top Five Stories of the Cellular Landscape and Therapies of Atherosclerosis: Current Knowledge and Future Perspectives
Pan, Q., Chen, C., & Yang, Y. (2023) · Current Medical Science · doi:10.1007/s11596-023-2818-2 · Cited by 4 · see citing works
The Impact of Hyaluronic Acid Coating on the Cationic Niosomal Surface for Doxorubicin Delivery
Mazzotta, E., Romeo, M., Sacco, G., Benedittis, S. D., Qualtieri, A., Perrotta, I. D., & Muzzalupo, R. (2025) · Molecules · doi:10.3390/molecules30051148 · Cited by 3 · see citing works
Metformin-Loaded Fusogenic Liposome Improves the Therapeutic Efficacy and Safety of Doxorubicin in a Breast Cancer Treatment
Pinheiro, T. M., Almeida, T. C. D. A., Silva, J. D. O., Lopes, J. L., Cassali, G. D., Melo, M. M., Lempek, M. R., Ferreira, R. D. S., Townsend, D. M., Leite, E. A., et al. (2025) · ACS Omega · doi:10.1021/acsomega.5c08220 · Cited by 3 · see citing works
Design, optimization of Niosomal gel capability for solubility and bioavailability enhancement of Kynurenic acid after intranasal administration: In Vitro and In Vivo Evaluation
Chettupalli, A. K., Bukke, S. P. N., Rahaman, S. A., Bodige, M., Kanakaraju, V. K., Kavitha, M., Srinivasarao, D., Mohammed, A., Goruntla, N., & Yadesa, T. M. (2025) · BMC Biotechnology · doi:10.1186/s12896-025-01069-y · Cited by 3 · see citing works
Formulation and evaluation of sustained release tablets of propranolol hydrochloride
Purohit, D., Gupta, M. K., Meher, C. P., Shukla, A., & Kumar, A. (2022) · International Journal of Health Sciences · doi:10.53730/ijhs.v6ns1.6287 · Cited by 3 · see citing works
PEGylated Lipid Nanocontainers Tailored with Sunseed-Oil-Based Solidified Reverse Micellar Solution for Enhanced Pharmacodynamics and Pharmacokinetics of Metformin
Kenechukwu, F. C., Nnamani, D. O., Nmesirionye, B. U., Isaac, G. T., Momoh, M. A., & Attama, A. A. (2022) · Journal of Pharmaceutical Innovation · doi:10.1007/s12247-022-09654-w · Cited by 3 · see citing works
An evaluation of the effects of ethosomes in the delivery of transdermal drugs
Gad, S., mousa, I., Hammady, T. M., & sayed, O. (2022) · Records of Pharmaceutical and Biomedical Sciences/Records of Pharmaceutical & Biomedical Sciences · doi:10.21608/rpbs.2022.141371.1147 · Cited by 3 · see citing works
A novel controlled release drug delivery system for naltrexone administration combined with intermittent morphine to induce antinociception
Javidan, A. N., Samadi, F. Y., Latifi, S., Jafari‐Nodoushan, M., & Mobedi, H. (2014) · Journal of Drug Delivery Science and Technology · doi:10.1016/s1773-2247(14)50082-2 · Cited by 3 · see citing works
Emerging nanotechnology-based therapies in the treatment of diabetes: recent developments and future opinion
Bhardwaj, A., Verma, S., Agnihotri, A., & Chitme, H. R. (2025) · Drug Development and Industrial Pharmacy · doi:10.1080/03639045.2025.2548844 · Cited by 2 · see citing works
α-pinene and β-sitosterol co-loaded alginate/gelatin-functionalized niosomes for enhanced antibacterial and anti-biofilm activity against methicillin-resistant Staphylococcus aureus and carbapenem-resistant Klebsiella pneumoniae
Ghoraba, H., Ashrafi, F., Nadushan, R. M., & Abbaspour, H. (2026) · BMC Biotechnology · doi:10.1186/s12896-026-01132-2 · Cited by 2 · see citing works

Metformin loaded non-ionic surfactant vesicles: optimization of formulation, effect of process variables and characterization
Sankhyan, A., & Pawar, P. (2013) · DARU Journal of Pharmaceutical Sciences · doi:10.1186/2008-2231-21-7 · Cited by 84 · see citing works
Formulation by Ether Injection Method and In-Vitro, In-Vivo Evaluation of Tween 80 Based Metformin Loaded Niosomes: A Smart Strategy in the Drug Delivery System
Alam, M. M., Anower, F. B., Sharna, K. N. H., Fahim, T. A., Alam, M. M., Akter, E., & Urmi, T. F. (2026) · Asian Journal of Applied Science and Technology · doi:10.38177/ajast.2026.10311
Metformin hydrochloride and wound healing: from nanoformulation to pharmacological evaluation
El-Ridy, M. S., Yehia, S. A., Elsayed, I., Younis, M. M., Abdel-Rahman, R. F., & El-Gamil, M. A. (2018) · Journal of Liposome Research · doi:10.1080/08982104.2018.1556291 · Cited by 45 · see citing works
Development of Anti-diabetic Niosomes Formulation Containing Metformin and Gliclazide
Kumar, B., & Jeyabalan, G. (2017) · Indian Journal of Pharmaceutical and Biological Research · doi:10.30750/ijpbr.5.2.5 · Cited by 2 · see citing works
FORMULATION, DEVELOPMENT AND CHARACTERIZATION OF EFFECTIVE NIOSOMAL DRUG DELIVERY SYSTEM FOR THE TREATMENT OF DIABETES MELLITUS
Musheer, N. M. N., & GUPTA, V. (2020) · Current Research in Pharmaceutical Sciences · doi:10.24092/crps.2020.100402

Authors: Hasan, A. A., Madkor, H., & Wageh, S.
Affiliations: Zagazig University (EG)
Al-Azhar University (EG)
Corresponding author: Hasan, Azza A.
ORCID: Madkor, Hafez
Venue: Drug Delivery
Publisher: Informa UK Limited
Published: 2013-04
Volume: 20
Issue: 3-4
Pages: 120-126
ISSN: 1071-7544 (ISSN-L)
1521-0464
DOI: 10.3109/10717544.2013.779332
OpenAlex: W2163002418
Cited by: 122
References: 39
Citations by year: 2026: 3 · 2025: 17 · 2024: 7 · 2023: 16 · 2022: 16 · 2021: 8 · 2020: 12 · 2019: 12 · 2018: 8 · 2017: 9 · 2016: 4 · 2015: 7 · 2014: 3
FWCI: 2.81
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Drug Delivery (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords: metformin hydrochloride, niosomes, controlled release, oral drug delivery, bioavailability, diabetes mellitus, lactic acidosis, DOTAP, dicetyl phosphate, encapsulation efficiency, hypoglycemic effect, pharmacokinetics, Span 40, cholesterol
MeSH terms: Animals, Blood Glucose, Chemistry, Pharmaceutical, Delayed-Action Preparations, Drug Evaluation, Preclinical, Liposomes, Male, Metformin, Random Allocation, Drug Delivery Systems, Rats, Wistar, Rats

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Formulation and evaluation of metformin hydrochloride-loaded niosomes as controlled release drug delivery system

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