Cited by 122Advanced Drug Delivery SystemsDrug Solubulity and Delivery SystemsNanoparticle-Based Drug Delivery

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Formulation and evaluation of metformin hydrochloride-loaded niosomes as controlled release drug delivery system

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Hasan, Azza A., Madkor, Hafez, Wageh, Sherief·2013·Drug Delivery

DOI 10.3109/10717544.2013.779332

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Abstract

Lactic acidosis is a serious, metabolic complication that may occur due to metformin hydrochloride (MH) accumulation during the treatment of diabetes mellitus. The aim of this study is to enhance the bioavailability of MH by oral route. Span 40 and cholesterol were used for the preparation of MH-loaded niosomes by the reverse phase evaporation technique. Dicetyl phosphate (DCP) and 1,2-dioleoyl-3-trimethylammonium-propane chloride salt (DOTAP) were used to obtain negatively and positively charged vesicles, respectively. The mean particle size ranged from 223.5 to 384.6 nm and the MH-loaded niosomes' surface was negatively charged in the absence of charge inducing agents (-16.6 ± 1.4 mV) and also with DCP (-26.9 ± 1.0 mV), while it was positively charged (+8.7 ± 1.2 mV) with DOTAP. High entrapment efficiency was observed in all the formulations. MH-loaded niosomes were found to effectively sustain the release of drug, particularly with positively charged niosomes. The bioavailability of MH-loaded niosomes was assessed by measuring the serum values of glucose and metformin in the different studied Wistar rats groups. The pharmacokinetic data of MH-loaded niosomal preparation showed a significant prolongation and increased intensity of hypoglycemic effect more than that observed for free MH solution. Area above the blood glucose levels-time curve (AAC), maximum hypoglycemic response and time of maximum response (T(max)) were significantly higher (p < 0.001) when MH was administered in niosomal form compared to free drug solution. It could be concluded that MH-loaded niosome is promising extended-release preparation with better hypoglycemic efficiency.

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Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)
(1998) · The Lancet · doi:10.1016/s0140-6736(98)07037-8 · Cited by 8,247
Determination of Glucose in Blood Using Glucose Oxidase with an Alternative Oxygen Acceptor
Trinder, P. (1969) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/000456326900600108 · Cited by 4,629
Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group.
(1998) · PubMed · Cited by 4,290
Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain
OWEN, M. R., DORAN, E., & HALESTRAP, A. P. (2000) · Biochemical Journal · doi:10.1042/bj3480607 · Cited by 2,157
Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I
El-Mir, M.-Y., Nogueira, V., Fontaine, E., Avéret, N., Rigoulet, M., & Leverve, X. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.1.223 · Cited by 1,399
Phase transitions in phospholipid vesicles Fluorescence polarization and permeability measurements concerning the effect of temperature and cholesterol
Papahadjopoulos, D., Jacobson, K., Nir, S., & Isac, I. (1973) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(73)90314-3 · Cited by 998
Studies on lecithin-cholesterol-water interactions by differential scanning calorimetry and X-ray diffraction
Ladbrooke, B. D., Williams, R. M., & Chapman, D. (1968) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(68)90132-6 · Cited by 890
Clinical Pharmacokinetics of Metformin
Scheen, A. J. (1996) · Clinical Pharmacokinetics · doi:10.2165/00003088-199630050-00003 · Cited by 649
Niosome: A future of targeted drug delivery systems
Kuotsu, K., Karim, K. M., Mandal, A. S., Biswas, N., Guha, A., Chatterjee, S., & Behera, M. (2010) · Journal of Advanced Pharmaceutical Technology amp Research · doi:10.4103/0110-5558.76435 · Cited by 627
Preparation and properties of vesicles (niosomes) of sorbitan monoesters (Span 20, 40, 60 and 80) and a sorbitan triester (Span 85)
YOSHIOKA, T., Sternberg, B., & Florence, A. T. (1994) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(94)90228-3 · Cited by 476

Show all 39 references

Research works printed but not linked: 5

Akhilesh D, Anoop VN, Rao BP. (2011). Formulation and evaluation of gliclazide loaded maltodextrin based proniosomes. Int J Res Pharm Biomed Sci 2:1582–9
Finkelstein MC, Weissman G. (1979). Enzyme replacement via liposomes. Int J Pharm 588:202–16
Khandare JN, Madhavi G, Tamhankar BM. (1994). Niosomes novel drug delivery system. East Pharm 37:61–4
10.1080/026520499288672 · DOI
Raja Naresh RA, Chandrashekhar G, Pillai GK, Udupa N. (1994). Anti-inflammatory activity of niosome encapsulated diclofenac sodium with Tween-85 in Arthitic rats. Indian J Pharmacol 26:46–8

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Authors: Hasan, A. A., Madkor, H., & Wageh, S.
Affiliations: Zagazig University (EG)
Al-Azhar University (EG)
Corresponding author: Hasan, Azza A.
ORCID: Madkor, Hafez
Venue: Drug Delivery
Publisher: Informa UK Limited
Published: 2013-04
Volume: 20
Issue: 3-4
Pages: 120-126
ISSN: 1071-7544 (ISSN-L)
1521-0464
DOI: 10.3109/10717544.2013.779332
OpenAlex: W2163002418
Cited by: 122
References: 39
Citations by year: 2026: 3 · 2025: 17 · 2024: 7 · 2023: 16 · 2022: 16 · 2021: 8 · 2020: 12 · 2019: 12 · 2018: 8 · 2017: 9 · 2016: 4 · 2015: 7 · 2014: 3
FWCI: 2.81
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Drug Delivery (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords: metformin hydrochloride, niosomes, controlled release, oral drug delivery, bioavailability, diabetes mellitus, lactic acidosis, DOTAP, dicetyl phosphate, encapsulation efficiency, hypoglycemic effect, pharmacokinetics, Span 40, cholesterol
MeSH terms: Animals, Blood Glucose, Chemistry, Pharmaceutical, Delayed-Action Preparations, Drug Evaluation, Preclinical, Liposomes, Male, Metformin, Random Allocation, Drug Delivery Systems, Rats, Wistar, Rats

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Formulation and evaluation of metformin hydrochloride-loaded niosomes as controlled release drug delivery system

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