The DOI matches its Crossref record; 38 of the 39 references it cites were found in a registry or an index.
Formulation and evaluation of metformin hydrochloride-loaded niosomes as controlled release drug delivery system
Open accessAbstract
Lactic acidosis is a serious, metabolic complication that may occur due to metformin hydrochloride (MH) accumulation during the treatment of diabetes mellitus. The aim of this study is to enhance the bioavailability of MH by oral route. Span 40 and cholesterol were used for the preparation of MH-loaded niosomes by the reverse phase evaporation technique. Dicetyl phosphate (DCP) and 1,2-dioleoyl-3-trimethylammonium-propane chloride salt (DOTAP) were used to obtain negatively and positively charged vesicles, respectively. The mean particle size ranged from 223.5 to 384.6 nm and the MH-loaded niosomes' surface was negatively charged in the absence of charge inducing agents (-16.6 ± 1.4 mV) and also with DCP (-26.9 ± 1.0 mV), while it was positively charged (+8.7 ± 1.2 mV) with DOTAP. High entrapment efficiency was observed in all the formulations. MH-loaded niosomes were found to effectively sustain the release of drug, particularly with positively charged niosomes. The bioavailability of MH-loaded niosomes was assessed by measuring the serum values of glucose and metformin in the different studied Wistar rats groups. The pharmacokinetic data of MH-loaded niosomal preparation showed a significant prolongation and increased intensity of hypoglycemic effect more than that observed for free MH solution. Area above the blood glucose levels-time curve (AAC), maximum hypoglycemic response and time of maximum response (T(max)) were significantly higher (p < 0.001) when MH was administered in niosomal form compared to free drug solution. It could be concluded that MH-loaded niosome is promising extended-release preparation with better hypoglycemic efficiency.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Pharmacokinetic testing confirmed the better efficacy of metformin-loaded niosomes over pure metformin in reducing blood glucose levels.84”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [84]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Determination of Glucose in Blood Using Glucose Oxidase with an Alternative Oxygen Acceptor
Trinder, P. (1969) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/000456326900600108 · Cited by 4,629
OWEN, M. R., DORAN, E., & HALESTRAP, A. P. (2000) · Biochemical Journal · doi:10.1042/bj3480607 · Cited by 2,157
El-Mir, M.-Y., Nogueira, V., Fontaine, E., Avéret, N., Rigoulet, M., & Leverve, X. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.1.223 · Cited by 1,399
Papahadjopoulos, D., Jacobson, K., Nir, S., & Isac, I. (1973) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(73)90314-3 · Cited by 998
Ladbrooke, B. D., Williams, R. M., & Chapman, D. (1968) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(68)90132-6 · Cited by 890
Clinical Pharmacokinetics of Metformin
Scheen, A. J. (1996) · Clinical Pharmacokinetics · doi:10.2165/00003088-199630050-00003 · Cited by 649
Niosome: A future of targeted drug delivery systems
Kuotsu, K., Karim, K. M., Mandal, A. S., Biswas, N., Guha, A., Chatterjee, S., & Behera, M. (2010) · Journal of Advanced Pharmaceutical Technology amp Research · doi:10.4103/0110-5558.76435 · Cited by 627
YOSHIOKA, T., Sternberg, B., & Florence, A. T. (1994) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(94)90228-3 · Cited by 476
Natali, A., & Ferrannini, E. (2006) · Diabetologia · doi:10.1007/s00125-006-0141-7 · Cited by 377
Studies on a high encapsulation of colchicine by a niosome system
Hao, Y., Zhao, F., Li, N., Yang, Y., & Li, K. (2002) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(02)00301-0 · Cited by 365
Guinedi, A. S., Mortada, N. D., Mansour, S., & Hathout, R. M. (2005) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2005.09.023 · Cited by 356
Applications of nanotechnology to biotechnology
West, J. L., & Halas, N. J. (2000) · Current Opinion in Biotechnology · doi:10.1016/s0958-1669(00)00082-3 · Cited by 343
Effect of liposomes and niosomes on skin permeation of enoxacin
Fang, J., Hong, C.-T., Chiu, W., & Wang, Y.-Y. (2001) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(01)00627-5 · Cited by 310
In vitro study of polyoxyethylene alkyl ether niosomes for delivery of insulin
Pardakhty, A., Varshosaz, J., & Rouholamini, A. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2006.08.002 · Cited by 292
International Textbook of Diabetes Mellitus
DeCherney, G. S. (1993) · JAMA · doi:10.1001/jama.1993.03510150107047 · Cited by 285
Role of Nanotechnology in Pharmaceutical Product Development
Devalapally, H., Chakilam, A. R., & Amiji, M. M. (2007) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.20875 · Cited by 232
Junyaprasert, V. B., Teeranachaideekul, V., & Supaperm, T. (2008) · AAPS PharmSciTech · doi:10.1208/s12249-008-9121-1 · Cited by 231
Bernkop‐Schnürch, A., Guggi, D., & Pinter, Y. (2003) · Journal of Controlled Release · doi:10.1016/j.jconrel.2003.10.005 · Cited by 221
Niosomes as carriers for tretinoin. I. Preparation and properties
Manconi, M., Sinico, C., Valenti, D., Loy, G., & Fadda, A. M. (2002) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(01)00971-1 · Cited by 209
Essa, E. A. (2010) · Asian Journal of Pharmaceutics · doi:10.4103/0973-8398.76752 · Cited by 147
Metformin in the digestive tract
Vidon, N., Chaussade, S., Noël, M., Franchisseur, C., Huchet, B., & Bernier, J. J. (1988) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(88)80022-6 · Cited by 117
Corti, G., Cirri, M., Maestrelli, F., Mennini, N., & Mura, P. (2007) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2007.06.004 · Cited by 116
Preparation and evaluation of acetazolamide liposomes as an ocular delivery system
El-Gazayerly, O. N., & Hikal, A. H. (1997) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(97)00186-5 · Cited by 113
Preparation and properties of new unilamellar non-ionic/ionic surfactant vesicles
Carafa, M., Santucci, E., Alhaique, F., Coviello, T., Murtas, E., Riccieri, F. M., Lucania, G., & Torrisi, M. R. (1998) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(97)00294-9 · Cited by 111
Drug encapsulation and release from multilamellar and unilamellar liposomes
Betageri, G. V., & Parsons, D. L. (1992) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(92)90015-t · Cited by 100
PEGylated synthetic surfactant vesicles (Niosomes): novel carriers for oligonucleotides
Huang, Y., Chen, J., Chen, X., Gao, J., & Liang, W. (2007) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-007-3193-4 · Cited by 91
Preparation and Characterization of Nonionic Surfactant Vesicles
van Hal, D. A., Bouwstra, J. A., van Rensen, A., Jeremiasse, E., de Vringer, T., & Junginger, H. E. (1996) · Journal of Colloid and Interface Science · doi:10.1006/jcis.1996.0114 · Cited by 90
Essa, E. A. (2010) · Asian Journal of Pharmaceutics · doi:10.22377/ajp.v4i4.289 · Cited by 77
Discoidal niosome based controlled ocular delivery of timolol maleate.
Vyas, S. P., Mysore, N., Jaitely, V., & Venkatesan, N. (1998) · PubMed · Cited by 76
PREPARATION AND EVALUATION OF NIOSOMES CONTAINING ACECLOFENAC
Srinivas, S. P., & Kumar, Y. (2010) · Cited by 58
Occult Metformin Toxicity in Three Patients with Profound Lactic Acidosis
Perrone, J., Phillips, C., & Gaieski, D. F. (2008) · Journal of Emergency Medicine · doi:10.1016/j.jemermed.2007.11.055 · Cited by 52
Lebacq, E., & Tirzmalis, A. (1972) · The Lancet · doi:10.1016/s0140-6736(72)90311-x · Cited by 40
Investigation of PEG 6000/Tween 80/Span 80/H2O niosome microstructure
Liu, T., & Guo, R. H. (2007) · Colloid & Polymer Science · doi:10.1007/s00396-006-1627-z · Cited by 24
Murugan, P., & Pari, L. (2007) · Journal of Applied Biomedicine · doi:10.32725/jab.2007.005 · Cited by 23
Niosomal Delivery Of Tenoxicam
Popli, H., & Nair, M. S. (1996) · Indian Journal of Pharmaceutical Sciences · Cited by 8
Formulation and Evaluation of Timolol Maleate Loaded Niosomes as an Ocular Drug Delivery System
Solyman, A. A. H. (2004) · Cited by 1
Research works printed but not linked: 5
- Akhilesh D, Anoop VN, Rao BP. (2011). Formulation and evaluation of gliclazide loaded maltodextrin based proniosomes. Int J Res Pharm Biomed Sci 2:1582–9
- Finkelstein MC, Weissman G. (1979). Enzyme replacement via liposomes. Int J Pharm 588:202–16
- Khandare JN, Madhavi G, Tamhankar BM. (1994). Niosomes novel drug delivery system. East Pharm 37:61–4
- 10.1080/026520499288672 · DOI
- Raja Naresh RA, Chandrashekhar G, Pillai GK, Udupa N. (1994). Anti-inflammatory activity of niosome encapsulated diclofenac sodium with Tween-85 in Arthitic rats. Indian J Pharmacol 26:46–8
Cited by
Sorted by citations
Type II diabetes mellitus: a review on recent drug based therapeutics.
Padhi, S., Nayak, A. K., & Behera, A. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110708 · Cited by 726
Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles
Singh, A. P., Biswas, A., Shukla, A., & Maiti, P. (2019) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-019-0068-3 · Cited by 645
Nanoparticle Delivery Systems in the Treatment of Diabetes Complications
Souto, E. B., Souto, S. B., Campos, J. R. S., Severino, P. B., Pashirova, T. N., Zakharova, L. Y., Silva, A. M., Durazzo, A., Lucarini, M., Izzo, A. A., et al. (2019) · Molecules · doi:10.3390/molecules24234209 · Cited by 254
Nanotechnology based approaches for anti-diabetic drugs delivery
Kesharwani, P., Gorain, B., Low, S. Y., Tan, S. A., Ling, E. C. S., Lim, Y. K., Chin, C. M., Lee, P. Y., Lee, C. M., Ooi, C. H., et al. (2017) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2017.11.018 · Cited by 204
Swamy, B. Y., & Yun, Y. (2015) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2015.03.019 · Cited by 166
Metadata
- Authors
- Hasan, A. A., Madkor, H., & Wageh, S.
- Affiliations
- Zagazig University (EG)
- Al-Azhar University (EG)
- Corresponding author
- Hasan, Azza A.
- ORCID
- Madkor, Hafez
- Venue
- Drug Delivery
- Publisher
- Informa UK Limited
- Published
- 2013-04
- Volume
- 20
- Issue
- 3-4
- Pages
- 120-126
- ISSN
- 1071-7544 (ISSN-L)
- 1521-0464
- OpenAlex
- W2163002418
- Cited by
- 122
- References
- 39
- Citations by year
- 2026: 3 · 2025: 17 · 2024: 7 · 2023: 16 · 2022: 16 · 2021: 8 · 2020: 12 · 2019: 12 · 2018: 8 · 2017: 9 · 2016: 4 · 2015: 7 · 2014: 3
- FWCI
- 2.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Drug Delivery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- metformin hydrochloride, niosomes, controlled release, oral drug delivery, bioavailability, diabetes mellitus, lactic acidosis, DOTAP, dicetyl phosphate, encapsulation efficiency, hypoglycemic effect, pharmacokinetics, Span 40, cholesterol
- MeSH terms
- Animals, Blood Glucose, Chemistry, Pharmaceutical, Delayed-Action Preparations, Drug Evaluation, Preclinical, Liposomes, Male, Metformin, Random Allocation, Drug Delivery Systems, Rats, Wistar, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
