The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Amidated Pectin Hydrogel Beads for Colonic Drug Delivery—An In Vitro Study
Open accessAbstract
Hydrogel beads of amidated pectins have been prepared by allowing individual droplets of the pectin solution to fall into calcium chloride solution. Beads have been produced containing either indomethacin or sulphamethoxazole as model drugs and either dextran or amylose to modify drug release. The beads formed were spherical in shape and had drug loading efficiencies of 80-95% for indomethacin and 60-90% for sulphamethoxazole. Thermal analysis indicated that there was no change in the form of the drugs after incorporation into the beads but that an interaction may have occurred between the pectin and either the dextran or amylose. Swelling of all the beads was similar, with a minimum occurring at pH 3. Drug release was related to the solubility of the compound, with sulphamethoxazole releasing more rapidly than indomethacin at all pH values. Indomethacin release was minimal at pH 3 and 5 but was significant at pH 7.4. However, the inclusion of amylose restricted the release at pH 7.4. When pectinolytic enzymes were included in the dissolution media, release was rapid. The results show that for a relatively insoluble compound, release in the conditions akin to the upper gastrointestinal tract can be minimized by the inclusion of amylose, without affecting the ability of the beads to break down in the presence of pectinolytic enzymes.
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“While AP has been studied as a potential carrier for colon-specific drug delivery, such systems often rely on calcium ion crosslinking [20,27].”
From Amidated Pectin/Nanocellulose Hybrid Cryogel System with a pH-Responsive Release Profile for Small Intestinal Delivery (2025) · cites this paper as [20]
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Cites
An evaluation of pectin as a carrier for drug targeting to the colon
Ashford, M. B., Fell, J. T., Attwood, D., Sharma, H. L., & Woodhead, P. J. (1993) · Journal of Controlled Release · doi:10.1016/0168-3659(93)90188-b · Cited by 252
Self-citationTargeting Drugs to the Colon: Delivery Systems for Oral Administration
Ashford, M. B., & Fell, J. T. (1994) · Journal of drug targeting · doi:10.3109/10611869408996806 · Cited by 178
Self-citationMilojevic, S., Newton, J. M., Cummings, J. H., Gibson, G. R., Botham, R. L., Ring, S. G., Stockham, M. A., & Allwood, M. C. (1996) · Journal of Controlled Release · doi:10.1016/0168-3659(95)00112-3 · Cited by 174
Munjeri, O., Collett, J. H., & Fell, J. T. (1997) · Journal of Controlled Release · doi:10.1016/s0168-3659(96)01607-0 · Cited by 174
Self-citationAnalysis of non-fickian transport in polymers using simplified exponential expressions
Sinclair, G., & Peppas, N. A. (1984) · Journal of Membrane Science · doi:10.1016/s0376-7388(00)83223-8 · Cited by 167
Milojevic, S., NEWTON, J. M., Cummings, J. H., et al. (1996) · Journal of Controlled Release · doi:10.1016/0168-3659(95)00113-1 · Cited by 85
Ramaraj, B., & Radhakrishnan, G. (1994) · Journal of Applied Polymer Science · doi:10.1002/app.1994.070520701 · Cited by 63
Release characteristics of ibuprofen from excipient-loaded alginate gel beads
Hwang, S., Rhee, G. J., Lee, K. M., et al. (1995) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(94)00281-9 · Cited by 51
Controlled release formulations of alachlor based on calcium alginate
Pepperman, A. B., & Kuan, J. W. (1995) · Journal of Controlled Release · doi:10.1016/0168-3659(94)00111-7 · Cited by 50
Østberg, T., Vesterhus, L., & Graffner, C. (1993) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(93)90138-6 · Cited by 50
Research works printed but not linked: 1
- Munjeri O, 1996, An Investigation into Colon-Specific Drug Delivery Properties of Amidated Pectin Based Hydrogel Beads
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Feng, S., Laurén, P., Zini, J., Gounani, Z., Bi, J., Yi, J., & Laaksonen, T. (2025) · Gels · doi:10.3390/gels11090700 · Cited by 5
“To date, AP has been explored as a potential drug carrier for colon-specific drug delivery but often requires the assistance of calcium ions [20,27].”
Metadata
- Authors
- Munjeri, O., Collett, J. H., & Fell, J. T.
- Affiliations
- University of Manchester (GB)
- ORCID
- Fell, J. T.
- Venue
- Drug Delivery
- Publisher
- Informa UK Limited
- Published
- 1997-01
- Volume
- 4
- Issue
- 3
- Pages
- 207-211
- ISSN
- 1071-7544 (ISSN-L)
- 1521-0464
- OpenAlex
- W2046264299
- Cited by
- 28
- References
- 11
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 2 · 2017: 1 · 2016: 2
- FWCI
- 0.82
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Drug Delivery (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Keywords
- amidated pectin, hydrogel beads, colon-targeted drug delivery, indomethacin, sulfamethoxazole, amylose, dextran, drug release, pH-dependent release, pectinase, drug loading efficiency, swelling
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