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Functional Correlates of Serotonin 5-HT1Recognition Sites
Abstract
A short overview is given of the evidence supporting the existence of subtypes of 5-HT1 receptors. As 5-HT1 receptors were first described using radioligand binding studies, a brief description of 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D receptor binding is given. Then, recent data obtained in biochemical, electrophysiological, behavioural and other functional studies is compared to results obtained in radioligand binding studies. The paper shows that functional correlates do indeed exist for subtypes of 5-HT1 recognition sites; moreover, these are markedly different from the effects mediated by 5-HT2 (5-HT D) or 5-HT3 (5-HT M) receptors.
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Citations
Cited by
Nichols, D. E. (2004) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2003.11.002 · Cited by 1,211
Shepherd, J. K., Grewal, S. S., Fletcher, A., Bill, D. J., & Dourish, C. T. (1994) · Psychopharmacology · doi:10.1007/bf02244871 · Cited by 739
Strassman, R. J. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950020022002 · Cited by 453
Central Serotonin and Impulsive Aggression
Coccaro, E. F. (1989) · British Journal of Psychiatry · doi:10.1192/s0007125000291769 · Cited by 451
Psychedelics in Psychiatry: Neuroplastic, Immunomodulatory, and Neurotransmitter Mechanisms
Inserra, A., De Gregorio, D., & Gobbi, G. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000056 · Cited by 232
Metadata
- Authors
- Hoyer, D.
- Venue
- Journal of Receptor Research
- Publisher
- Informa UK Limited
- Published
- 1988-01
- Volume
- 8
- Issue
- 1-4
- Pages
- 59-81
- ISSN
- 0197-5110 (ISSN-L)
- OpenAlex
- W2038361574
- Cited by
- 562
- References
- 0
- FWCI
- 20.20
- Type
- journal article
- Language
- en
- Open access
- closed
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
