Presence of cytomegalovirus DNA in leucocytes is associated with increased oxidative stress and subclinical atherosclerosis in healthy adults
Abstract
OBJECTIVE: Investigate the latent cytomegalovirus (CMV) infection as a biomarker of oxidative stress and atherosclerosis. METHODS: Latent CMV infection was diagnosed in healthy individuals with PCR-evidence of CMV DNA in peripheral leucocytes. Oxidative stress and atherosclerosis were measured by mitochondrial DNA oxidative damage index (mtDNA(ΔCT)) and intima media thickness (IMT). RESULTS: The CMV DNA positive subjects had a higher mean mtDNA(ΔCT) and greater IMT than subjects in the control group. CONCLUSIONS: Presence of CMV DNA in leucocytes, as a marker of latent CMV infection, was associated with increased levels of oxidative stress and subclinical atherosclerosis in healthy adults.
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Healthy individuals infected with CMV exhibit elevated biomarkers of oxidative stress.
“Further, healthy individuals infected with CMV exhibit elevated biomarkers of oxidative stress (Lee et al. 2014)”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Lee et al. 2014
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References 45 · Cited by 29
- Authors
- Lee, Y.-L., Liu, C.-E., Cho, W.-L., Kuo, C.-L., Cheng, W.-L., Huang, C.-S., & Liu, C.-S.
- Affiliations
- Changhua Christian Hospital (TW)
- China Medical University Hospital (TW)
- National Yang Ming University (TW)
- Corresponding author
- Liu, Chin-San
- Venue
- Biomarkers
- Publisher
- Informa UK Limited
- Published
- 2014-01-22
- Volume
- 19
- Issue
- 2
- Pages
- 109-113
- ISSN
- 1354-750X (ISSN-L)
- 1366-5804
- OpenAlex
- W2141579378
- Cited by
- 29
- References
- 45
- Citations by year
- 2025: 1 · 2022: 3 · 2021: 3 · 2020: 4 · 2018: 4 · 2017: 4 · 2016: 5 · 2015: 4 · 2014: 1
- FWCI
- 3.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biomarkers (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Keywords
- cytomegalovirus infection, viral latency, oxidative stress, subclinical atherosclerosis, mitochondrial DNA damage, intima-media thickness, healthy adults
- MeSH terms
- Cytomegalovirus Infections, Cytomegalovirus, DNA, Viral, Female, Humans, Leukocytes, Mononuclear, Male, Middle Aged, Biomarkers, Virus Latency, Oxidative Stress, Atherosclerosis, Carotid Intima-Media Thickness
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