Impact of smoking on estrogenic efficacy

Ruan, X.; Mueck, A. O.

doi:10.3109/13697137.2014.929106

Cited by 61Menopause: Health Impacts and TreatmentsEstrogen and related hormone effectsSmoking Behavior and Cessation

Impact of smoking on estrogenic efficacy

Ruan, X., Mueck, A. O.·2015·Climacteric

DOI 10.3109/13697137.2014.929106

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Abstract

Depending on the type, duration and intensity of cigarette smoking, the efficacy of endogenous and exogenous estrogen can be reduced or completely cancelled. Not only does smoking diminish the beneficial effects of estrogen on hot flushes and urogenital symptoms and its positive effects on lipid metabolism, but smoking also can reduce estrogen's ability to prevent osteoporosis and perhaps also cardiovascular diseases. This is mainly caused by dose-dependent elevated hepatic clearance, partially in conjunction with lower estrogen levels, and has been demonstrated so far only with oral estrogen applications. Compensation for the failure of therapeutic action should not be made by increasing the dose in smokers since this might result in the production of potentially mutagenic estrogen metabolites associated with a higher risk of breast cancer. Since the favorable effects of estrogens seem to be not lost in smokers when estrogens are applied transdermally, this route should be preferred in smokers. The most important conclusion from the data presented is that the effects of smoking are very complex and dependent on a multiplicity of factors, so that different types of clinically relevant negative effects must be expected. Women who continue to smoke despite all warnings should be informed that smoking, in addition to all its other negative effects, can also jeopardize the success of hormone replacement therapy.

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Skeletal System Biology and Smoke Damage: From Basic Science to Medical Clinic
Tarantino, U., Cariati, I., Greggi, C., Gasbarra, E., Belluati, A., Ciolli, L., Maccauro, G., Momoli, A., Ripanti, S., Falez, F., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126629 · Cited by 52 · see citing works

Authors: Ruan, X., & Mueck, A. O.
Affiliations: Capital Medical University (CN)
Corresponding author: Mueck, A. O.
ORCID: Ruan, X.
Venue: Climacteric
Publisher: Informa UK Limited
Published: 2014-07-29
Volume: 18
Issue: 1
Pages: 38-46
ISSN: 1369-7137 (ISSN-L)
1473-0804
DOI: 10.3109/13697137.2014.929106
OpenAlex: W2022603579
Cited by: 61
References: 78
Citations by year: 2026: 4 · 2025: 4 · 2024: 7 · 2023: 8 · 2022: 5 · 2021: 7 · 2020: 6 · 2019: 3 · 2018: 9 · 2017: 3 · 2016: 4 · 2015: 1
FWCI: 0.42
Type: journal article
Language: en
Open access: closed
Locations: Climacteric (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
Keywords: cigarette smoking, hormone replacement therapy, estrogen metabolites, breast cancer risk, transdermal estrogen, hot flashes, urogenital symptoms, osteoporosis prevention, cardiovascular disease, lipid metabolism, smoking cessation
MeSH terms: Contraindications, Administration, Cutaneous, Estrogens, Female, Humans, Smoking, Estrogen Replacement Therapy

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Impact of smoking on estrogenic efficacy

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