Molecular signalings in keloid disease and current therapeutic approaches from natural based compounds
Open accessAbstract
CONTEXT: Keloid is an excessive dermal scar occurring in response to skin injuries. Several therapeutic strategies have been proposed to ease the aggressiveness of keloid scarring. Even though the principle mechanism underlying the disease propagation still remains unidentified, several signaling pathways were highly focused as plausible pathways involving keloid formation, including transforming growth factor-beta 1 (TGF-β1), mitogen-activated protein kinase (MAPK), insulin-like growth factor-I (IGF-I), and integrin pathways. Natural compounds containing multiple bioeffective properties such as quercetin, asiaticoside, Astragalus membranaceus Bunge. (Leguminosae), and Salvia miltiorrhiza Bunge. (Lamiaceae) extracts, curcuminoids, oxymatrine, madecassoside, and Aneilema keisak Hassk. (Commelinaceae) are claimed as candidates for therapeutic treatment against keloid disorder. OBJECTIVE: This review investigates current mechanisms regarding keloid formation and provides scientific evidence supporting the therapeutic potential of natural compounds. METHODS: This review obtained and analyzed a number of literature data items from various databases including Pubmed, ScienceDirect, and Elton B. Stephens Company (EBSCO). RESULT: Several phytochemical compounds are able to suppress keloid scar development through manipulating various components in the complex signaling cascades. CONCLUSION: The present review may be helpful to future studies that further examine the molecular mechanism of keloid etiology as well as investigate the anti-keloid property in natural compounds.
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Other controlled studies have confirmed the role of asiaticoside and madecassoside in enhancing wound healing and diminishing hypertrophic and keloid scars.
“Other controlled studies have further confirmed the role of asiaticoside and madecassoside in enhancing wound healing and diminishing hypertrophic and keloid scars.”
From Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review (2023) · cites this paper as [95]
The Natural-based therapies section reports that asiaticoside affects signaling and extracellular-matrix production in keloid fibroblasts, while madecassoside inhibits keloid-fibroblast migration and is reported to reduce keloid formation. It does not describe controlled studies confirming that these compounds enhance wound healing or diminish hypertrophic scars; the wound-healing study discussed there concerns curcumin. (LLM, conf=0.88)
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Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review
Bandopadhyay, S., Mandal, S., Ghorai, M., Jha, N. K., Kumar, M., Radha, Ghosh, A., Proćków, J., Pérez de la Lastra, J. M., & Dey, A. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17635 · Cited by 220 · see citing works
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- Authors
- Unahabhokha, T., Sucontphunt, A., Nimmannit, U., Chanvorachote, P., Yongsanguanchai, N., & Pongrakhananon, V.
- Affiliations
- Chulalongkorn University (TH)
- National Science and Technology Development Agency (TH)
- ,
- Corresponding author
- Pongrakhananon, Varisa
- Venue
- Pharmaceutical Biology
- Publisher
- Informa UK Limited
- Published
- 2014-10-21
- Volume
- 53
- Issue
- 3
- Pages
- 457-463
- ISSN
- 0925-1618 (ISSN-L)
- 1388-0209
- 1744-5116
- OpenAlex
- W2058903665
- Cited by
- 70
- References
- 53
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 9 · 2023: 7 · 2022: 14 · 2021: 6 · 2020: 3 · 2019: 7 · 2018: 4 · 2017: 4 · 2016: 2 · 2015: 3
- FWCI
- 0.50
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Pharmaceutical Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Keywords
- keloids, TGF-β1 signaling, MAPK signaling, IGF-1 signaling, integrin signaling, natural compounds, phytochemicals, quercetin, asiaticoside, Astragalus membranaceus, Salvia miltiorrhiza, curcuminoids, oxymatrine, madecassoside, scar formation
- MeSH terms
- Animals, Biological Products, Humans, Keloid, Signal Transduction, Mitogen-Activated Protein Kinases, Transforming Growth Factor beta1
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