Cardiovascular function in women with recurrent miscarriage, pre-eclampsia and/or intrauterine growth restriction
Abstract
OBJECTIVE: To investigate prepregnancy cardiovascular function and risk factors in women with previous pregnancy complications. METHODS: Thirty-four women with previous normal pregnancy (controls), 26 with unexplained recurrent miscarriage (RM) and 14 with pre-eclampsia (PE) and/or intrauterine growth restriction (IUGR), planning to conceive were recruited. Brachial and central blood pressures (BP), cardiac output (CO), peripheral vascular resistance (PVR), aortic stiffness, blood biochemistry and platelet aggregation were assessed. RESULTS: Women with previous PE/IUGR had higher brachial diastolic BP (78 ± 9 vs 71 ± 7 mmHg; p = 0.03), central systolic BP (107 ± 10 vs 99 ± 8 mmHg; p = 0.03), mean arterial pressure (92 ± 10 vs 84 ± 8 mmHg; p = 0.01) and PVR (1499 ± 300 vs 1250 ± 220 dynes.s(-1) cm(-5); p = 0.005), than the controls. No differences were observed in either cardiovascular function or blood biochemistry in women with unexplained RM compared with the controls. Women with previous PE/IUGR though not with RM had a stronger family history of cardiovascular disease (CVD) than controls. CONCLUSIONS: Women with previous PE and/or IUGR had higher BP and PVR compared with controls, which may predispose them to CVD later in life. However, in the absence of underlying vascular pathology, women with unexplained RM did not have abnormal cardiovascular function. Prepregnancy period provides an opportunity to identify cardiovascular risks in relation to previous obstetric history.
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Families of women with a history of reproductive complications were also at an increased risk of cardiovascular disease and so genetic predispositions could have a role.
“Families of women with a history of reproductive complications were also at an increased risk of cardiovascular disease and so genetic predispositions could have a role”
From Association between the reproductive health of young women and cardiovascular disease in later life: umbrella review (2020) · cites this paper as [137]
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- Authors
- Mahendru, A. A., Everett, T. R., McEniery, C. M., Wilkinson, I. B., & Lees, C. C.
- Affiliations
- Rosie Hospital (GB)
- University of Cambridge (GB)
- Corresponding author
- Lees, Christoph C.
- Venue
- The Journal of Maternal-Fetal & Neonatal Medicine
- Publisher
- Informa UK Limited
- Published
- 2012-11-02
- Volume
- 26
- Issue
- 4
- Pages
- 351-356
- ISSN
- 1476-4954 (ISSN-L)
- 1476-7058
- OpenAlex
- W2132257284
- Cited by
- 19
- References
- 39
- Citations by year
- 2024: 2 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 3 · 2017: 1 · 2016: 3 · 2015: 2 · 2014: 1 · 2013: 1
- FWCI
- 1.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Maternal-Fetal & Neonatal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- British Heart Foundation (FS/12/8/29377)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Keywords
- cardiovascular function, recurrent pregnancy loss, preeclampsia, fetal growth restriction, systemic vascular resistance, blood pressure, aortic stiffness, platelet aggregation, family history of cardiovascular disease, pregnancy complications
- MeSH terms
- Abortion, Habitual, Adult, Blood Pressure, Cardiac Output, Cardiovascular Diseases, Cardiovascular System, Female, Fetal Growth Retardation, Humans, Platelet Aggregation, Pre-Eclampsia, Pregnancy, Pregnancy Complications, Cardiovascular, Prospective Studies, Risk Factors, Vascular Resistance, Vascular Stiffness
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