The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Sterile intra-amniotic inflammation in asymptomatic patients with a sonographic short cervix: prevalence and clinical significance
Open accessAbstract
OBJECTIVE: To determine the frequency and clinical significance of sterile and microbial-associated intra-amniotic inflammation in asymptomatic patients with a sonographic short cervix. METHODS: Amniotic fluid (AF) samples obtained by transabdominal amniocentesis from 231 asymptomatic women with a sonographic short cervix [cervical length (CL) ≤25 mm] were analyzed using cultivation techniques (for aerobic and anaerobic as well as genital mycoplasmas) and broad-range polymerase chain reaction (PCR) coupled with electrospray ionization mass spectrometry (PCR/ESI-MS). The frequency and magnitude of intra-amniotic inflammation [defined as an AF interleukin (IL)-6 concentration ≥2.6 ng/mL], acute histologic placental inflammation, spontaneous preterm delivery (sPTD), and the amniocentesis-to-delivery interval were examined according to the results of AF cultures, PCR/ESI-MS and AF IL-6 concentrations. RESULTS: Ten percent (24/231) of patients with a sonographic short cervix had sterile intra-amniotic inflammation (an elevated AF IL-6 concentration without evidence of microorganisms using cultivation and molecular methods). Sterile intra-amniotic inflammation was significantly more frequent than microbial-associated intra-amniotic inflammation [10.4% (24/231) versus 2.2% (5/231); p < 0.001]. Patients with sterile intra-amniotic inflammation had a significantly higher rate of sPTD <34 weeks of gestation [70.8% (17/24) versus 31.6% (55/174); p < 0.001] and a significantly shorter amniocentesis-to-delivery interval than patients without intra-amniotic inflammation [median 35, (IQR: 10-70) versus median 71, (IQR: 47-98) days, (p < 0.0001)]. CONCLUSION: Sterile intra-amniotic inflammation is more common than microbial-associated intra-amniotic inflammation in asymptomatic women with a sonographic short cervix, and is associated with increased risk of sPTD (<34 weeks). Further investigation is required to determine the causes of sterile intra-amniotic inflammation and the mechanisms whereby this condition is associated with a short cervix and sPTD.
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Cites
The length of the cervix and the risk of spontaneous premature delivery
Iams, J. D., Goldenberg, R. L., Meis, P. J., Mercer, B. M., Moawad, A., Das, A., Thom, E., McNellis, D., Copper, R. L., Johnson, F., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199602293340904 · Cited by 1,894
The preterm parturition syndrome
Romero, R., Espinoza, J., Kusanovic, J., Gotsch, F., Hassan, S., Erez, O., Chaiworapongsa, T., & Mazor, M. (2006) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2006.01120.x · Cited by 1,419
Self-citationRomero, R., Sirtori, M., Oyarzun, E., Avila, C., Mazor, M., Callahan, R., Sabo, V., Athanassiadis, A. P., & Hobbins, J. C. (1989) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(89)90409-2 · Cited by 678
Self-citationAndrews, W. W., Hauth, J. C., Goldenberg, R. L., Gomez, R., Romero, R., & Cassell, G. H. (1995) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(95)90290-2 · Cited by 247
Self-citationYoon, B. H., Romero, R., Lim, J.-H., Shim, S.-S., Hong, J.-S., Shim, J.-Y., & Jun, J. K. (2003) · American Journal of Obstetrics and Gynecology · doi:10.1067/s0002-9378(03)00839-1 · Cited by 210
Self-citationAdverse outcome in pregnancy following amniotic fluid isolation of Ureaplasma urealyticum
Gray, D. J., Robinson, H. B., Malone, J., & Thomson, R. B. (1992) · Prenatal Diagnosis · doi:10.1002/pd.1970120206 · Cited by 187
Cited by
Acute chorioamnionitis and funisitis: definition, pathologic features, and clinical significance
Kim, C. J., Romero, R., Chaemsaithong, P., Chaiyasit, N., Yoon, B. H., & Kim, Y. M. (2015) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2015.08.040 · Cited by 910
Self-citationMicrobial Changes during Pregnancy, Birth, and Infancy
Nuriel-Ohayon, M., Neuman, H., & Koren, O. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01031 · Cited by 620
Romero, R., Conde-Agudelo, A., Da Fonseca, E., O’Brien, J. M., Cetingoz, E., Creasy, G. W., Hassan, S. S., & Nicolaides, K. H. (2018) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.11.576 · Cited by 522
Self-citationTheis, K. R., Romero, R., Winters, A. D., Greenberg, J. M., Gomez-Lopez, N., Alhousseini, A., Bieda, J., Maymon, E., Pacora, P., Fettweis, J. M., et al. (2019) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2018.10.018 · Cited by 258
Self-citationChorioamniotic membrane senescence: a signal for parturition?
Behnia, F., Taylor, B. D., Woodson, M., Kacerovsky, M., Hawkins, H., Fortunato, S. J., Saade, G. R., & Menon, R. (2015) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2015.05.041 · Cited by 163
Metadata
- Authors
- Romero, R., Miranda, J., Chaiworapongsa, T., Chaemsaithong, P., Gotsch, F., Dong, Z., Ahmed, A. I., Yoon, B. H., Hassan, S. S., Kim, C. J., Korzeniewski, S. J., Yeo, L., & Kim, Y. M.
- Venue
- The Journal of Maternal-Fetal & Neonatal Medicine
- Publisher
- Informa UK Limited
- Published
- 2014-09-24
- Volume
- 28
- Issue
- 11
- Pages
- 1343-1359
- ISSN
- 1476-4954 (ISSN-L)
- 1476-7058
- OpenAlex
- W2049511993
- Cited by
- 202
- References
- 6
- FWCI
- 13.03
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Romero, R., Miranda, J., Chaiworapongsa, T., Chaemsaithong, P., Gotsch, F., Dong, Z., Ahmed, A. I., Yoon, B. H., Hassan, S. S., Kim, C. J., Korzeniewski, S. J., Yeo, L., & Kim, Y. M. (2015). Sterile intra-amniotic inflammation in asymptomatic patients with a sonographic short cervix: prevalence and clinical significance. The Journal of Maternal-Fetal & Neonatal Medicine. https://doi.org/10.3109/14767058.2014.954243
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