The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
The Cost of Opioid-Related Adverse Drug Events
Abstract
Opioids are the cornerstone of pain management; however, their use is associated with a variety of adverse drug events (ADEs) ranging from nausea and vomiting to urinary retention and respiratory depression. The purpose of this review is to describe the frequency and cost associated with different types of opioid-related ADEs to better understand their economic impact. A search of studies published in journals from 1946 to December, 2013, was conducted using MEDLINE and EMBASE. A total of 20 articles were reviewed. Data reflect a substantial economic burden of opioid-related ADEs resulting in high hospital costs, prolonged hospital stays, and substantial health care resource usage. Nausea, vomiting, and constipation are frequent and increased costs occur in all types of pain (surgical, nonsurgical, cancer, noncancer) in both inpatients and outpatients. Given the large economic burden of opioid-related ADEs, prevention rather than treatment may be the most effective strategy.
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“and 2 -14% of these patients experience at least one opioid-related adverse event. 7”
From Randomized Controlled Trial of Brief Mindfulness Training and Hypnotic Suggestion for Acute Pain Relief in the Hospital Setting. (2017) · cites this paper as [7]
Citations
Cites
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Cited by
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Garland, E. L., Baker, A. K., Larsen, P., Riquino, M. R., Priddy, S. E., Thomas, E., Hanley, A. W., Galbraith, P., Wanner, N., & Nakamura, Y. (2017) · Journal of General Internal Medicine · doi:10.1007/s11606-017-4116-9 · Cited by 109
Metadata
- Authors
- Kane-Gill, S. L., Rubin, E. C., Smithburger, P. L., Buckley, M. S., & Dasta, J. F.
- Venue
- Journal of Pain & Palliative Care Pharmacotherapy
- Publisher
- Informa UK Limited
- Published
- 2014-08-07
- Volume
- 28
- Issue
- 3
- Pages
- 282-293
- ISSN
- 1536-0288 (ISSN-L)
- 1536-0539
- OpenAlex
- W2089192992
- Cited by
- 111
- References
- 39
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 5 · 2023: 6 · 2022: 11 · 2021: 17 · 2020: 15 · 2019: 11 · 2018: 14 · 2017: 6 · 2016: 10 · 2015: 4 · 2014: 1
- FWCI
- 6.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Pain & Palliative Care Pharmacotherapy (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Keywords
- opioids, adverse drug reactions, economic burden, cost of care, nausea and vomiting, constipation, respiratory depression, urinary retention, hospital costs, length of hospital stay, healthcare resource utilization, pain management, cancer pain
- MeSH terms
- Analgesics, Opioid, Constipation, Humans, Nausea, Vomiting, Cost of Illness, Drug-Related Side Effects and Adverse Reactions
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