The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
The Cost of Opioid-Related Adverse Drug Events
Abstract
Opioids are the cornerstone of pain management; however, their use is associated with a variety of adverse drug events (ADEs) ranging from nausea and vomiting to urinary retention and respiratory depression. The purpose of this review is to describe the frequency and cost associated with different types of opioid-related ADEs to better understand their economic impact. A search of studies published in journals from 1946 to December, 2013, was conducted using MEDLINE and EMBASE. A total of 20 articles were reviewed. Data reflect a substantial economic burden of opioid-related ADEs resulting in high hospital costs, prolonged hospital stays, and substantial health care resource usage. Nausea, vomiting, and constipation are frequent and increased costs occur in all types of pain (surgical, nonsurgical, cancer, noncancer) in both inpatients and outpatients. Given the large economic burden of opioid-related ADEs, prevention rather than treatment may be the most effective strategy.
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“and 2 -14% of these patients experience at least one opioid-related adverse event. 7”
From Randomized Controlled Trial of Brief Mindfulness Training and Hypnotic Suggestion for Acute Pain Relief in the Hospital Setting. (2017) · cites this paper as [7]
Citations
Cites
Barr, J., Fraser, G. L., Puntillo, K., Ely, E. W., Gélinas, C., Dasta, J. F., Davidson, J. E., Devlin, J. W., Kress, J. P., Joffe, A. M., et al. (2012) · Critical Care Medicine · doi:10.1097/ccm.0b013e3182783b72 · Cited by 3,896
Self-citationIncidence of Adverse Drug Events and Potential Adverse Drug Events: Implications for Prevention
Bates, D. W. (1995) · JAMA · doi:10.1001/jama.1995.03530010043033 · Cited by 2,127
Classen, D. C. (1997) · JAMA · doi:10.1001/jama.277.4.301 · Cited by 1,897
Bates, D. W. (1997) · JAMA · doi:10.1001/jama.277.4.307 · Cited by 1,678
Association Between Opioid Prescribing Patterns and Opioid Overdose-Related Deaths
Bohnert, A. S. B. (2011) · JAMA · doi:10.1001/jama.2011.370 · Cited by 1,509
Opioids in chronic non-cancer pain: systematic review of efficacy and safety
Kalso, E., Edwards, J. E., Moore, A. R., & McQuay, H. J. (2004) · Pain · doi:10.1016/j.pain.2004.09.019 · Cited by 1,216
The Costs of Adverse Drug Events in Hospitalized Patients
Bates, D. W. (1997) · JAMA · doi:10.1001/jama.1997.03540280045032 · Cited by 1,072
Management of opioid side effects in cancer-related and chronic noncancer pain: a systematic review
McNicol, E. D., Horowicz-Mehler, N., Fisk, R. A., Bennett, K. C., Gialeli-Goudas, M., Chew, P. W., Lau, J., & Carr, D. B. (2003) · Journal of Pain · doi:10.1016/s1526-5900(03)00556-x · Cited by 466
Costs of medical injuries in Utah and Colorado.
Thomas, E. J., Studdert, D. M., Newhouse, J. P., Zbar, B. I. W., Howard, K., WILLIAMS, E. J., & Brennan, T. A. (1999) · PubMed · Cited by 395
Moore, R. A., & McQuay, H. J. (2005) · Arthritis Research & Therapy · doi:10.1186/ar1782 · Cited by 377
Opioid-Related Adverse Drug Events in Surgical Hospitalizations: Impact on Costs and Length of Stay
Oderda, G. M., Said, Q., Evans, R. S., Stoddard, G. J., Lloyd, J., Jackson, K. C., Rublee, D. A., & Samore, M. H. (2007) · Annals of Pharmacotherapy · doi:10.1345/aph.1h386 · Cited by 367
Cost-effectiveness of Prophylactic Antiemetic Therapy with Ondansetron, Droperidol, or Placebo
Hill, R. P., Lubarsky, D. A., Phillips‐Bute, B., et al. (2000) · Anesthesiology · doi:10.1097/00000542-200004000-00012 · Cited by 366
Economic Burden of Postoperative Ileus Associated With Colectomy in the United States
Iyer, S. S., Saunders, W. B., & Stemkowski, S. (2009) · Journal of Managed Care Pharmacy · doi:10.18553/jmcp.2009.15.6.485 · Cited by 337
Kessler, E. R., Shah, M. B., Gruschkus, S. K., & Raju, A. (2013) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/phar.1223 · Cited by 313
Postoperative Ileus: It Costs More Than You Expect
Asgeirsson, T., El‐Badawi, K. I., Mahmood, A., Barletta, J. F., Luchtefeld, M. A., & Senagore, A. J. (2009) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2009.09.028 · Cited by 303
Long-Term Opioid Therapy Reconsidered
Korff, M. V., Kolodny, A., Deyo, R. A., & Chou, R. (2011) · Annals of Internal Medicine · doi:10.7326/0003-4819-155-5-201109060-00011 · Cited by 261
Effect of Opioid-Related Adverse Events on Outcomes in Selected Surgical Patients
Oderda, G. M., Gan, T. J., Johnson, B. H., et al. (2013) · Journal of Pain & Palliative Care Pharmacotherapy · doi:10.3109/15360288.2012.751956 · Cited by 241
The moral limits of Feinberg's liberalism
Doppelt, G. (1993) · Inquiry · doi:10.1080/00201749308602322 · Cited by 231
Cost of Opioid-Related Adverse Drug Events in Surgical Patients
Oderda, G. M., Evans, R. S., Lloyd, J. F., Lipman, A. G., Chen, C., Ashburn, M. A., Burke, J. P., & Samore, M. H. (2003) · Journal of Pain and Symptom Management · doi:10.1016/s0885-3924(02)00691-7 · Cited by 217
Adverse drug events in intensive care units: Risk factors, impact, and the role of team care
Kane‐Gill, S. L., Jacobi, J., & Rothschild, J. M. (2010) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181dd8364 · Cited by 147
Self-citationCosts incurred by outpatient surgical centers in managing postoperative nausea and vomiting
Carroll, N. V., Miederhoff, P. A., Cox, F. M., et al. (1994) · Journal of Clinical Anesthesia · doi:10.1016/s0952-8180(05)80004-2 · Cited by 107
The Direct and Indirect Costs of Opioid-Induced Constipation
Hjalte, F., Berggren, A.-C., Bergendahl, H. T. G., et al. (2010) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2010.02.019 · Cited by 83
Devlin, J. W., & Roberts, R. J. (2011) · Anesthesiology Clinics · doi:10.1016/j.anclin.2011.09.001 · Cited by 71
Candrilli, S. D., Davis, K. L., & Iyer, S. S. (2009) · Journal of Pain & Palliative Care Pharmacotherapy · doi:10.1080/15360280903098440 · Cited by 71
Costs of Gastrointestinal Events after Outpatient Opioid Treatment for Non-Cancer Pain
Kwong, W. J., Diels, J., & Kavanagh, S. (2010) · Annals of Pharmacotherapy · doi:10.1345/aph.1m520 · Cited by 48
Dunlop, W., Uhl, R., Khan, I., Taylor, A., & Barton, G. (2012) · Journal of Medical Economics · doi:10.3111/13696998.2012.665279 · Cited by 46
Neighbors, D. M., BELL, T. J., Wilson, J., et al. (2001) · Journal of Pain and Symptom Management · doi:10.1016/s0885-3924(00)00247-5 · Cited by 43
Iyer, S. S., Davis, K. L., & Candrilli, S. D. (2010) · PubMed · Cited by 36
Voepel‐Lewis, T., WAGNER, D. S., Burke, C. N., et al. (2012) · Pediatric Anesthesia · doi:10.1111/pan.12026 · Cited by 32
Wee, B. L., Adams, A., Thompson, K., et al. (2010) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2009.09.007 · Cited by 30
Frei, A., Andersen, S., HOLE, P., & Jensen, N. (2003) · Journal of Pain & Palliative Care Pharmacotherapy · doi:10.1080/j354v17n02_02 · Cited by 27
Ivanova, J. I., Birnbaum, H. G., Yushkina, Y., et al. (2013) · Journal of Opioid Management · doi:10.5055/jom.2013.0165 · Cited by 25
Suh, D., Kim, M. S., Chow, W. S., & Jang, E.-J. (2011) · Clinical Journal of Pain · doi:10.1097/ajp.0b013e31820d9b76 · Cited by 23
Anastassopoulos, K. P., Chow, W. S., Tapia, C. I., Baik, R., Ackerman, S. J., Biondi, D. M., & Kim, M. S. (2012) · Journal of Managed Care Pharmacy · doi:10.18553/jmcp.2012.18.8.615 · Cited by 22
Efficacy and Safety of Dual-Opioid Therapy in Acute Pain
Webster, L. R. (2012) · Pain Medicine · doi:10.1111/j.1526-4637.2012.01330.x · Cited by 20
Haß, B., Lungershausen, J., Hertel, N., et al. (2008) · The European Journal of Health Economics · doi:10.1007/s10198-008-0134-1 · Cited by 17
Radbruch, L., Lehmann, K. A., Gockel, H.-H., Neighbors, D. M., & Nuyts, G. (2002) · The European Journal of Health Economics · doi:10.1007/s10198-002-0097-6 · Cited by 15
Takemoto, M. L. S., Fernandes, R. A., Almeida, G. R., et al. (2011) · Value in Health · doi:10.1016/j.jval.2011.05.019 · Cited by 13
Flynn, T., & Guest, J. (1999) · Journal of Medical Economics · doi:10.3111/199902015032 · Cited by 5
Research works printed but not linked: 8
- Thomas EJ, 1999, Inquiry., 36, 255
- Bates DW, 1995, ADE Prevention Study Group. JAMA., 274, 29
- Institute of Medicine, Committee on Identifying and Preventing Medication Errors, Preventing Medication Errors. Washington, DC: National Academies Press; 2007:124–125.
- Ford D, Luttrell N. Leadership in patient safety: IV pump auto-programming. Paper presented at Cerner Health Conference; October 2009; Kansas City, MO.
- Duggan AK, 1995, Br J Med Econ., 9, 21
- Classen DC, 1997, JAMA., 277, 301, 10.1001/jama.1997.03540280039031 · DOI
- Iyer S, 2010, Managed Care., 19, 44
- Swegle JM, 2006, Ann Fam Physician., 74, 1347
Cited by
Sorted by citations
Garland, E. L., Baker, A. K., Larsen, P., Riquino, M. R., Priddy, S. E., Thomas, E., Hanley, A. W., Galbraith, P., Wanner, N., & Nakamura, Y. (2017) · Journal of General Internal Medicine · doi:10.1007/s11606-017-4116-9 · Cited by 109
Metadata
- Authors
- Kane-Gill, S. L., Rubin, E. C., Smithburger, P. L., Buckley, M. S., & Dasta, J. F.
- Venue
- Journal of Pain & Palliative Care Pharmacotherapy
- Publisher
- Informa UK Limited
- Published
- 2014-08-07
- Volume
- 28
- Issue
- 3
- Pages
- 282-293
- ISSN
- 1536-0288 (ISSN-L)
- 1536-0539
- OpenAlex
- W2089192992
- Cited by
- 111
- References
- 39
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 5 · 2023: 6 · 2022: 11 · 2021: 17 · 2020: 15 · 2019: 11 · 2018: 14 · 2017: 6 · 2016: 10 · 2015: 4 · 2014: 1
- FWCI
- 6.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Pain & Palliative Care Pharmacotherapy (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Keywords
- opioids, adverse drug reactions, economic burden, cost of care, nausea and vomiting, constipation, respiratory depression, urinary retention, hospital costs, length of hospital stay, healthcare resource utilization, pain management, cancer pain
- MeSH terms
- Analgesics, Opioid, Constipation, Humans, Nausea, Vomiting, Cost of Illness, Drug-Related Side Effects and Adverse Reactions
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