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Cited by 141Nanoparticles: synthesis and applicationsCarcinogens and Genotoxicity AssessmentAir Quality and Health Impacts

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Nano-TiO2– feasibility and challenges for human health risk assessment based on open literature

Christensen, Frans M., Johnston, Helinor J., Stone, Vicki, Aitken, Robert J., Hankin, Steve, Peters, Sheona, Aschberger, Karin·2011·Nanotoxicology
DOI 10.3109/17435390.2010.504899
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Abstract

This study aims at investigating feasibility and challenges associated with conducting a human health risk assessment for nano-titanium-dioxide (nano-TiO₂) based on the open literature by following an approach similar to a classical regulatory risk assessment. Gaps in the available data set, both in relation to exposures and hazard, do not allow reaching any definite conclusions that could be used for regulatory decision-making. Results show that repeated inhalation in the workplace and possibly consumer inhalation may cause risks. Also short-term inhalation following spray applications may cause risks. Main future work should focus on generating occupational and consumer inhalation exposure data, as well as toxicity data on absorption following inhalation, repeated dermal contact, and contact with damaged skin. Also relevant seems further information on possible neurotoxicity and genotoxicity/carcinogenicity, as well as establishing a No Observed Adverse Effect Level (NOAEL) for acute inhalation of nano-TiO₂.

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References 93 · Cited by 141

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Metadata

Authors
Christensen, F. M., Johnston, H. J., Stone, V., Aitken, R. J., Hankin, S., Peters, S., & Aschberger, K.
Affiliations
  • European Commission (BE)
  • Edinburgh Napier University (GB)
  • Institute of Occupational Medicine (GB)
Corresponding author
Christensen, Frans M.
ORCID
Venue
Nanotoxicology
Publisher
Informa UK Limited
Published
2010-08-23
Volume
5
Issue
2
Pages
110-124
ISSN
  • 1743-5390 (ISSN-L)
  • 1743-5404
DOI
10.3109/17435390.2010.504899
OpenAlex
W2101660988
Cited by
141
References
93
Citations by year
2026: 2 · 2025: 1 · 2024: 2 · 2023: 4 · 2022: 4 · 2021: 7 · 2020: 2 · 2019: 8 · 2018: 5 · 2017: 12 · 2016: 15 · 2015: 11 · 2014: 21 · 2013: 15 · 2012: 19
FWCI
7.39
Type
journal article
Language
en
Open access
closed
Locations
  • Nanotoxicology (publishedVersion)
  • PubMed (publishedVersion)
  • Joint Research Centre (European Commission) (submittedVersion)
Funders
Seventh Framework Programme
Topics
  • Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
Keywords
nano-titanium dioxide, human health risk assessment, inhalation exposure, occupational exposure, consumer exposure, spray application, dermal exposure, neurotoxicity, genotoxicity, carcinogenicity, no-observed-adverse-effect level, regulatory risk assessment, data gaps
MeSH terms
Animals, Humans, Risk Factors, Titanium, Occupational Exposure, Risk Assessment, No-Observed-Adverse-Effect Level, Inhalation Exposure, Nanoparticles

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