The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Titanium dioxide nanoparticles exhibit genotoxicity and impair DNA repair activity in A549 cells
Abstract
Titanium dioxide nanoparticles (TiO(2)-NPs) are produced in large quantities, raising concerns about their impact for human health. The aim of this study was to deeply characterize TiO(2)-NPs genotoxic potential to lung cells, and to link genotoxicity to physicochemical characteristics, e.g., size, specific surface area, crystalline phase. A549 cells were exposed to a panel of TiO(2)-NPs with diameters ranging from 12 to 140 nm, either anatase or rutile. A set of complementary techniques (comet and micronucleus assays, gamma-H2AX immunostaining, 8-oxoGuanine analysis, H2-DCFDA, glutathione content, antioxidant enzymes activities) allowed us to demonstrate that small and spherical TiO(2)-NPs, both anatase and rutile, induce single-strand breaks and oxidative lesions to DNA, together with a general oxidative stress. Additionally we show that these NPs impair cell ability to repair DNA, by inactivation of both NER and BER pathways. This study thus confirms the genotoxic potential of TiO(2)-NPs, which may preclude their mutagenicity and carcinogenicity.
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Cited by
Mechanisms of genotoxicity. A review of in vitro and in vivo studies with engineered nanoparticles
Magdolenova, Z., Collins, A., Kumar, A., Dhawan, A., Stone, V., & Dusinska, M. (2014) · Nanotoxicology · doi:10.3109/17435390.2013.773464 · Cited by 616
Nanomaterials in food and agriculture: An overview on their safety concerns and regulatory issues
Jain, A., Ranjan, S., Dasgupta, N., & Ramalingam, C. (2018) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2016.1160363 · Cited by 367
Brun, E., Barreau, F., Veronesi, G., Fayard, B., Sorieul, S., Chanéac, C., Carapito, C., Rabilloud, T., Mabondzo, A., Herlin-Boime, N., et al. (2014) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-11-13 · Cited by 299
Self-citationToxicity and regulations of food nanomaterials
Ranjan, S., Dasgupta, N., Singh, S., & Gandhi, M. (2019) · Environmental Chemistry Letters · doi:10.1007/s10311-018-00851-z · Cited by 62
Metadata
- Authors
- Jugan, M.-L., Barillet, S., Simon-Deckers, A., Herlin-Boime, N., Sauvaigo, S., Douki, T., & Carriere, M.
- Venue
- Nanotoxicology
- Publisher
- Informa UK Limited
- Published
- 2011-10-13
- Volume
- 6
- Issue
- 5
- Pages
- 501-513
- ISSN
- 1743-5390 (ISSN-L)
- 1743-5404
- OpenAlex
- W1988156579
- Cited by
- 206
- References
- 4
- FWCI
- 3.73
- Type
- journal article
- Language
- en
- Open access
- closed
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- Jugan, M.-L., Barillet, S., Simon-Deckers, A., Herlin-Boime, N., Sauvaigo, S., Douki, T., & Carriere, M. (2012). Titanium dioxide nanoparticles exhibit genotoxicity and impair DNA repair activity in A549 cells. Nanotoxicology. https://doi.org/10.3109/17435390.2011.587903
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