The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.
Titanium dioxide nanoparticle impact and translocation through ex vivo, in vivo and in vitro gut epithelia
Open accessAbstract
BACKGROUND: TiO2 particles are commonly used as dietary supplements and may contain up to 36% of nano-sized particles (TiO2-NPs). Still impact and translocation of NPs through the gut epithelium is poorly documented. RESULTS: We show that, in vivo and ex vivo, agglomerates of TiO2-NPs cross both the regular ileum epithelium and the follicle-associated epithelium (FAE) and alter the paracellular permeability of the ileum and colon epithelia. In vitro, they accumulate in M-cells and mucus-secreting cells, much less in enterocytes. They do not cause overt cytotoxicity or apoptosis. They translocate through a model of FAE only, but induce tight junctions remodeling in the regular ileum epithelium, which is a sign of integrity alteration and suggests paracellular passage of NPs. Finally we prove that TiO2-NPs do not dissolve when sequestered up to 24 h in gut cells. CONCLUSIONS: Taken together these data prove that TiO2-NPs would possibly translocate through both the regular epithelium lining the ileum and through Peyer's patches, would induce epithelium impairment, and would persist in gut cells where they would possibly induce chronic damage.
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Cites
1 retracted
Nanosized TiO2-Induced Reproductive System Dysfunction and Its Mechanism in Female Mice
Zhao, X., Ze, Y., Gao, G., Sang, X., Li, B., Gui, S., Sheng, L., Sun, Q., Cheng, J., Cheng, Z., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059378 · Cited by 112
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Titanium Dioxide Nanoparticles in Food and Personal Care Products
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Titanium dioxide nanoparticles: a review of current toxicological data
Shi, H., Magaye, R., Castranova, V., & Zhao, J. (2013) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-10-15 · Cited by 1,498
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Cited by
Mofijur, M., Ahmed, S. F., Rahman, S. M. A., Arafat Siddiki, S. Y., Islam, A. B. M. S., Shahabuddin, M., Ong, H. C., Mahlia, T. M. I., Djavanroodi, F., & Show, P. L. (2021) · Environmental Research · doi:10.1016/j.envres.2021.110857 · Cited by 172
Nanoparticle Transport Across the Placental Barrier: Pushing the Field Forward!
Muoth, C., Aengenheister, L., Kucki, M., Wick, P., & Buerki-Thurnherr, T. (2016) · Nanomedicine · doi:10.2217/nnm-2015-0012 · Cited by 146
Mechanisms of uptake and transport of particulate formulations in the small intestine
Delon, L., Gibson, R. J., Prestidge, C. A., & Thierry, B. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.02.006 · Cited by 64
In Vitro Models of Biological Barriers for Nanomedical Research
Carton, F., & Malatesta, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23168910 · Cited by 34
Metadata
- Authors
- Brun, E., Barreau, F., Veronesi, G., Fayard, B., Sorieul, S., Chanéac, C., Carapito, C., Rabilloud, T., Mabondzo, A., Herlin-Boime, N., & Carrière, M.
- Venue
- Particle and Fibre Toxicology
- Published
- 2014-03-25
- Volume
- 11
- Issue
- 1
- Pages
- 13-13
- ISSN
- 1743-8977 (ISSN-L)
- OpenAlex
- W2131755453
- Cited by
- 299
- References
- 62
- FWCI
- 10.72
- Type
- journal article
- Language
- en
- Open access
- gold
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- Brun, E., Barreau, F., Veronesi, G., Fayard, B., Sorieul, S., Chanéac, C., Carapito, C., Rabilloud, T., Mabondzo, A., Herlin-Boime, N., & Carrière, M. (2014). Titanium dioxide nanoparticle impact and translocation through ex vivo, in vivo and in vitro gut epithelia. Particle and Fibre Toxicology. https://doi.org/10.1186/1743-8977-11-13
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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