Sleep-disordered breathing in obese adolescents is associated with visceral adiposity and markers of insulin resistance
Open accessAbstract
Sleep-disordered breathing is associated with obesity, insulin resistance, and the metabolic syndrome in adults. Similar data in children is limited and conflicting. This pilot study examined the relationships between sleep-disordered breathing, visceral adiposity, and cardiometabolic risk factors in obese adolescents. Twenty obese (body mass index ≥ 95(th) percentile), otherwise healthy adolescents (age 14.9 ± 2 years) underwent polysomnogram studies, fasting lipid profile and oral glucose tolerance tests, and measures of body composition (dual-energy X-ray absorptiometry) and visceral adiposity (abdominal computed tomography). The severity of sleep-disordered breathing (as measured by apnea-hypopnea index) was positively associated with visceral adipose tissue (r = 0.73, p < 0.001) but not with other measures of body composition. After controlling for body mass index, the severity of sleep-disordered breathing was positively associated with markers of insulin resistance (homeostasis model assessment and fasting insulin). Further study to allow for critical assessment of the relationships between sleep-disordered breathing and cardiometabolic risk factors in obese youth remains necessary.
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OSA has been associated with insulin resistance in children.
“OSA has been associated with T2DM risk in adults (10) and with IR in children (11,12).”
From Sleep architecture and glucose and insulin homeostasis in obese adolescents (2011) · cites this paper as [11]
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(2007) · Cited by 6,530 · see citing works
The metabolic syndrome in children and adolescents
Zimmet, P., Alberti, G., KAUFMAN, F. R., Tajima, N., Silink, M., Arslanian, S. A., Wong, G., Bennett, P. H., Shaw, J. E., & Caprio, S. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60958-1 · Cited by 963 · see citing works
Self-citationNormal Polysomnographic Values for Children and Adolescents
Marcus, C. L., Omlin, K. J., Basinki, D. J., Bailey, S. L., Rachal, A. B., von Pechmann, W. S., Keens, T. G., & Ward, S. L. D. (1992) · American Review of Respiratory Disease · doi:10.1164/ajrccm/146.5_pt_1.1235 · Cited by 808 · see citing works
Normal Polysomnographic Respiratory Values in Children and Adolescents
Uliel‐Sibony, S., Tauman, R., Greenfeld, M., & Sivan, Y. (2004) · CHEST Journal · doi:10.1378/chest.125.3.872 · Cited by 460 · see citing works
Yeckel, C. W., Weiss, R., Dziura, J., Taksali, S. E., Dufour, S., Burgert, T. S., Tamborlane, W. V., & Caprio, S. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031503 · Cited by 352 · see citing works
Association between Metabolic Syndrome and Sleep-disordered Breathing in Adolescents
Redline, S. S., Storfer‐Isser, A., ROSEN, C. L., Johnson, N. L., Kirchner, H. L., Emancipator, J. L., & Kibler, A. M. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200703-375oc · Cited by 300 · see citing works
Verhulst, S. L., Schrauwen, N., Haentjens, D., Suys, B. E., Rooman, R., Gaal, L. V., Backer, W. A. D., & Desager, K. N. (2006) · Archives of Disease in Childhood · doi:10.1136/adc.2006.101089 · Cited by 271 · see citing works
Metabolic correlates with obstructive sleep apnea in obese subjects
Eva, R. C. D., Baur, L. A., Donaghue, K. C., & Waters, K. A. (2002) · The Journal of Pediatrics · doi:10.1067/mpd.2002.123765 · Cited by 213 · see citing works
Association between Inadequate Sleep and Insulin Resistance in Obese Children
Flint, J. K., Kothare, S. V., Zihlif, M., Suarez, E. A., Adams, R., Legido, A., & Luca, F. D. (2007) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2006.08.063 · Cited by 163 · see citing works
Tauman, R., O'Brien, L. M., Ivanenko, A., & Gozal, D. (2005) · PEDIATRICS · doi:10.1542/peds.2004-2527 · Cited by 153 · see citing works
Verhulst, S. L., Schrauwen, N., Haentjens, D., Rooman, R., Gaal, L. V., Backer, W. A. D., & Desager, K. N. (2007) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2007.01.051 · Cited by 140 · see citing works
Obstructive Sleep-Disordered Breathing and Fasting Insulin Levels in Nonobese Children
Kaditis, A. G., Alexopoulos, E. Ι., Damani, E., Καραδόντα, Ι., Kostadima, E., Tsolakidou, A., Gourgoulianis, K. I., & Syrogiannopoulos, G. A. (2005) · Pediatric Pulmonology · doi:10.1002/ppul.20306 · Cited by 93 · see citing works
Racial Differences in Adiponectin in Youth: Relationship to visceral fat and insulin sensitivityv
Lee, S. (2006) · Diabetes Care · doi:10.2337/diacare.29.1.51 · Cited by 90 · see citing works
Self-citationRacial Differences in Adiponectin in Youth
Lee, S., Bacha, F. F., Gungor, N., & Arslanian, S. A. (2006) · Diabetes Care · doi:10.2337/diacare.29.01.06.dc05-0952 · Cited by 86 · see citing works
Self-citationNakra, N., Bhargava, S., Dzuira, J. D., Caprio, S., & Bazzy‐Asaad, A. (2008) · PEDIATRICS · doi:10.1542/peds.2008-0154 · Cited by 81 · see citing works
Bacha, F. F., Gungor, N., & Arslanian, S. A. (2008) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2007.11.044 · Cited by 57 · see citing works
Self-citationInsulin and obstructive sleep apnea in obese Chinese children
Li, A. M., Chan, M. H. M., Chan, D. F. Y., Lam, H. S., Wong, E. M. C., So, H., Chan, I. H.-S., Lam, C. W. K., & Nelson, E. A. S. (2006) · Pediatric Pulmonology · doi:10.1002/ppul.20508 · Cited by 54 · see citing works
Puberty and Upper Airway Dynamics During Sleep
Bandla, P., Huang, J., Karamessinis, L. R., Kelly, A. T., Pepe, M. E., Samuel, J. M., Brooks, L. J., Mason, T. A., Gallagher, P. R., & Marcus, C. L. (2008) · SLEEP · doi:10.1093/sleep/31.4.534 · Cited by 30 · see citing works
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Arslanian, S., Bacha, F., Grey, M., Marcus, M. D., White, N. H., & Zeitler, P. (2018) · Diabetes Care · doi:10.2337/dci18-0052 · Cited by 349 · see citing works
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Hannon, T. S., & Arslanian, S. A. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12939 · Cited by 137 · see citing works
Self-citationSleep architecture and glucose and insulin homeostasis in obese adolescents
Koren, D., Levitt Katz, L. E., Brar, P. C., Gallagher, P. R., Berkowitz, R. I., & Brooks, L. J. (2011) · Diabetes Care · doi:10.2337/dc11-1093 · Cited by 134 · see citing works
“OSA has been associated with T2DM risk in adults (10) and with IR in children (11,12).”
Chen, M. E., Chandramouli, A. G., Considine, R. V., Hannon, T. S., & Mather, K. J. (2018) · Diabetes Care · doi:10.2337/dc17-1373 · Cited by 26 · see citing works
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- Authors
- Hannon, T. S., Lee, S., Chakravorty, S., Lin, Y., & Arslanian, S. A.
- Affiliations
- University of Pittsburgh Medical Center (US)
- University of Pittsburgh (US)
- Children's Hospital of Pittsburgh (US)
- Venue
- International Journal of Pediatric Obesity
- Publisher
- Informa UK Limited
- Published
- 2011-04
- Volume
- 6
- Issue
- 2
- Pages
- 157-160
- ISSN
- 1747-7166 (ISSN-L)
- 1747-7174
- PMC
- PMC3428196
- OpenAlex
- W2132375119
- Cited by
- 47
- References
- 18
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 4 · 2017: 5 · 2016: 8 · 2015: 2 · 2014: 6 · 2013: 5 · 2012: 4
- FWCI
- 2.82
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- International Journal of Pediatric Obesity (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (UL1TR000005)
- National Institute of Diabetes and Digestive and Kidney Diseases (K12DK063704)
- National Center for Research Resources (UL1RR024153)
- National Center for Advancing Translational Sciences
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (K24HD001357, K24 HD 01357)
- Topics
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- sleep-disordered breathing, obstructive sleep apnea, adolescent obesity, visceral fat, insulin resistance, cardiometabolic risk, apnea-hypopnea index, HOMA-IR, fasting insulin, body composition, metabolic syndrome
- MeSH terms
- Adolescent, Child, Female, Humans, Insulin Resistance, Male, Obesity, Prospective Studies, Sleep Apnea Syndromes, Intra-Abdominal Fat, Adiposity
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