Cited by 107Wound Healing and TreatmentsAdvancements in Transdermal Drug DeliveryEssential Oils and Antimicrobial Activity

Wound healing effects of nanoemulsion containing clove essential oil

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Alam, Prawez, Ansari, Mohammad J., Anwer, Md. Khalid, Raish, Mohammad, Kamal, Yoonus K. T., Shakeel, Faiyaz·2017·Artificial Cells Nanomedicine and Biotechnology

Abstract

The aim of this study was to investigate the wound healing effects of clove oil (CO) via its encapsulation into nanoemulsion. Optimized nanoemulsion (droplet size of 29.10 nm) was selected for wound healing investigation, collagen determination, and histopathological examination in rats. Optimized nanoemulsion presented significant would healing effects in rats as compared to pure CO. Nanoemulsion also presented significant enhancement in leucine content (0.61 mg/g) as compared to pure CO (0.50 mg/g) and negative control (0.31 mg/g). Histopathology of nanoemulsion treated rats showed no signs of inflammatory cells. These results suggested that nanoemulsion of CO was safe and nontoxic.

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Crossref · 10.3109/21691401.2016.1163716

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  • CEO decreased the levels of inflammatory biomarkers VCAM-1, IP-10, I-TAC, and MIG, and inhibited the tissue remodeling protein molecules collagen I, collagen III, M-CSF, and TIMP-1.

    “It decreased the levels of inflammatory biomarkers such as VCAM-1, IP-10, I-TAC, and MIG, in addition to inhibiting the tissue remodeling protein molecules collagen I, collagen III, M-CSF, and TIMP-1 [26,87,109].”

    From Clove essential oil (Syzygium aromaticum L. Myrtaceae): Extraction, chemical composition, food applications, and essential bioactivity for human health (2021) · cites this paper as [109]

    In “Estimation of collagen content” (page unavailable), the paper says clove-oil nanoemulsion increased collagen content in rat wound tissue, rather than reporting collagen inhibition. The paper does not report measurements of collagen I or III individually, or of the listed inflammatory biomarkers, M-CSF, or TIMP-1. (LLM, conf=0.83)

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Authors
Alam, P., Ansari, M. J., Anwer, M. K., Raish, M., Kamal, Y. K. T., & Shakeel, F.
Affiliations
  • Prince Sattam Bin Abdulaziz University (SA)
  • King Saud University (SA)
Corresponding author
  • Alam, Prawez
  • Shakeel, Faiyaz
Venue
Artificial Cells Nanomedicine and Biotechnology
Published
2016-03-26
Volume
45
Issue
3
Pages
591-597
ISSN
  • 2169-1401 (ISSN-L)
  • 2169-141X
OpenAlex
W2323497474
Cited by
104
References
37
Citations by year
2026: 2 · 2025: 17 · 2024: 7 · 2023: 18 · 2022: 18 · 2021: 19 · 2020: 8 · 2019: 9 · 2018: 4 · 2017: 2
FWCI
5.39
Type
journal article
Language
en
Open access
Locations
  • Artificial Cells Nanomedicine and Biotechnology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Prince Sattam bin Abdulaziz University
Topics
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
Keywords
clove oil, nanoemulsions, wound healing, encapsulation, collagen, leucine, histopathology, toxicity, rats
MeSH terms
Animals, Anti-Bacterial Agents, Collagen, Emulsions, Female, Glycerides, Particle Size, Polysorbates, Skin, Triacetin, Wound Healing, Rats, Wistar, Clove Oil, Nanostructures, Rats

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