Cited by 107Wound Healing and TreatmentsAdvancements in Transdermal Drug DeliveryEssential Oils and Antimicrobial Activity

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Wound healing effects of nanoemulsion containing clove essential oil

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Alam, Prawez, Ansari, Mohammad J., Anwer, Md. Khalid, Raish, Mohammad, Kamal, Yoonus K. T., Shakeel, Faiyaz·2017·Artificial Cells Nanomedicine and Biotechnology

DOI 10.3109/21691401.2016.1163716

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Abstract

The aim of this study was to investigate the wound healing effects of clove oil (CO) via its encapsulation into nanoemulsion. Optimized nanoemulsion (droplet size of 29.10 nm) was selected for wound healing investigation, collagen determination, and histopathological examination in rats. Optimized nanoemulsion presented significant would healing effects in rats as compared to pure CO. Nanoemulsion also presented significant enhancement in leucine content (0.61 mg/g) as compared to pure CO (0.50 mg/g) and negative control (0.31 mg/g). Histopathology of nanoemulsion treated rats showed no signs of inflammatory cells. These results suggested that nanoemulsion of CO was safe and nontoxic.

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Authors: Alam, P., Ansari, M. J., Anwer, M. K., Raish, M., Kamal, Y. K. T., & Shakeel, F.
Affiliations: Prince Sattam Bin Abdulaziz University (SA)
King Saud University (SA)
Corresponding author: Alam, Prawez
Shakeel, Faiyaz
ORCID: Alam, Prawez
Ansari, Mohammad J.
Anwer, Md. Khalid
Raish, Mohammad
Shakeel, Faiyaz
Venue: Artificial Cells Nanomedicine and Biotechnology
Publisher: Informa UK Limited
Published: 2016-03-26
Volume: 45
Issue: 3
Pages: 591-597
ISSN: 2169-1401 (ISSN-L)
2169-141X
DOI: 10.3109/21691401.2016.1163716
OpenAlex: W2323497474
Cited by: 104
References: 37
Citations by year: 2026: 2 · 2025: 17 · 2024: 7 · 2023: 18 · 2022: 18 · 2021: 19 · 2020: 8 · 2019: 9 · 2018: 4 · 2017: 2
FWCI: 5.39
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Artificial Cells Nanomedicine and Biotechnology (publishedVersion)
PubMed (publishedVersion)
Funders: Prince Sattam bin Abdulaziz University
Topics: Health Sciences › Medicine › Surgery › Wound Healing and Treatments
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
Keywords: clove oil, nanoemulsions, wound healing, encapsulation, collagen, leucine, histopathology, toxicity, rats
MeSH terms: Animals, Anti-Bacterial Agents, Collagen, Emulsions, Female, Glycerides, Particle Size, Polysorbates, Skin, Triacetin, Wound Healing, Rats, Wistar, Clove Oil, Nanostructures, Rats

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Wound healing effects of nanoemulsion containing clove essential oil

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