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Wound healing effects of nanoemulsion containing clove essential oil
Open accessAbstract
The aim of this study was to investigate the wound healing effects of clove oil (CO) via its encapsulation into nanoemulsion. Optimized nanoemulsion (droplet size of 29.10 nm) was selected for wound healing investigation, collagen determination, and histopathological examination in rats. Optimized nanoemulsion presented significant would healing effects in rats as compared to pure CO. Nanoemulsion also presented significant enhancement in leucine content (0.61 mg/g) as compared to pure CO (0.50 mg/g) and negative control (0.31 mg/g). Histopathology of nanoemulsion treated rats showed no signs of inflammatory cells. These results suggested that nanoemulsion of CO was safe and nontoxic.
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“It decreased the levels of inflammatory biomarkers such as VCAM-1, IP-10, I-TAC, and MIG, in addition to inhibiting the tissue remodeling protein molecules collagen I, collagen III, M-CSF, and TIMP-1 [26,87,109].”
From Clove essential oil (Syzygium aromaticum L. Myrtaceae): Extraction, chemical composition, food applications, and essential bioactivity for human health (2021) · cites this paper as [109]
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Metadata
- Authors
- Alam, P., Ansari, M. J., Anwer, M. K., Raish, M., Kamal, Y. K. T., & Shakeel, F.
- Affiliations
- Prince Sattam Bin Abdulaziz University (SA)
- King Saud University (SA)
- Corresponding author
- Alam, Prawez
- Shakeel, Faiyaz
- Venue
- Artificial Cells Nanomedicine and Biotechnology
- Publisher
- Informa UK Limited
- Published
- 2016-03-26
- Volume
- 45
- Issue
- 3
- Pages
- 591-597
- ISSN
- 2169-1401 (ISSN-L)
- 2169-141X
- OpenAlex
- W2323497474
- Cited by
- 104
- References
- 37
- Citations by year
- 2026: 2 · 2025: 17 · 2024: 7 · 2023: 18 · 2022: 18 · 2021: 19 · 2020: 8 · 2019: 9 · 2018: 4 · 2017: 2
- FWCI
- 5.39
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Artificial Cells Nanomedicine and Biotechnology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Prince Sattam bin Abdulaziz University
- Topics
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Keywords
- clove oil, nanoemulsions, wound healing, encapsulation, collagen, leucine, histopathology, toxicity, rats
- MeSH terms
- Animals, Anti-Bacterial Agents, Collagen, Emulsions, Female, Glycerides, Particle Size, Polysorbates, Skin, Triacetin, Wound Healing, Rats, Wistar, Clove Oil, Nanostructures, Rats
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