Polymorphism in Pharmaceutical Solids

Abstract

THERMODYNAMIC AND THEORETICAL ISSUES Theory and Principles of Polymorphic Systems, Harry G. Brittain Application of the Phase Rule to the Characterization of Polymorphic and Solvatomorphic Systems, Harry G. Brittain Computational Methodologies: Toward Crystal Structure and Polymorph Prediction, Sarah (Sally) L. Price PREPARATIVE METHODS FOR POLYMORPHS AND SOLVATOMORPHS Classical Methods of Preparation of Polymorphs and Alternative Solid Forms, Peter W. Cains Approaches to High-Throughput Physical Form Screening and Discovery, Alastair J. Florence STRUCTURAL PROPERTIES OF POLYMORPHS AND SOLVATOMORPHS Structural Aspects of Polymorphism, Harry G. Brittain, Stephen R. Byrn, and Eunhee Lee Structural Aspects of Solvatomorphic Systems, Harry G. Brittain, Kenneth R. Morris, and Stephan X. M. Boerrigter Pharmaceutical Co-crystals: A New Opportunity in Pharmaceutical Science for a Long-Known but Little-Studied Class of Compounds, Kapildev K. Arora and Michael J. Zaworotko CHARACTERIZATION METHODS FOR POLYMORPHS AND SOLVATOMORPHS Thermoanalytical and Crystallographic Methods, Sisir Bhattacharya, Harry G. Brittain, and Raj Suryanarayanan Vibrational Spectroscopy, Harry G. Brittain Solid-State Nuclear Magnetic Resonance Spectroscopy, Patrick A. Tishmack Effects of Polymorphism and Solid-State Solvation on Solubility and Dissolution Rate, Harry G. Brittain, David J. R. Grant, and Paul B. Myrdal INTERCONVERSION OF POLYMORPHS AND SOLVATOMORPHS Solid-State Phase Transformations, Harry G. Brittain Effects of Pharmaceutical Processing on the Solid Form of Drug and Excipient Materials, Peter L. D. Wildfong SPECIAL TOPICS RELATED TO POLYMORPHISM AND SOLVATOMORPHISM Structural Aspects of Molecular Dissymmetry, Harry G. Brittain Amorphous Solids, Lynne S. Taylor and Sheri L. Shamblin Index