Drug hydrate systems and dehydration processes studied by terahertz pulsed spectroscopy
Abstract
Terahertz pulsed spectroscopy was used to distinguish between different hydrate systems. In the example of four pharmaceutical materials lactose, carbamazepine, piroxicam and theophylline it was demonstrated that all different hydrate and anhydrate forms exhibit distinct spectra in the far infrared. Furthermore the dehydration of theophylline monohydrate was characterised in situ. Here, a phase transition from the monohydrate to the anhydrous form was observed, followed by evaporation of the hydrate water in a second step. The rotational spectrum of water vapour is very characteristic in the far infrared and can easily be discerned from the terahertz spectrum of the solid state form.
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The peaks at 0.53 THz, 1.17 THz, and 1.37 THz are characteristic absorption peaks of α-lactose monohydrate.
“The peaks at 0.53 THz [47, 48], 1.17 THz [49, 50] and 1.37 THz [51, 52] are the characteristic absorption peaks of α-lactose monohydrate [10, 49, 53].”
From THz-TDS Time-Trace Analysis for the Extraction of Material and Metamaterial Parameters (2019) · cites this paper as [51]
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Terahertz spectroscopy and imaging - Modern techniques and applications
Jepsen, P. U., Cooke, D. G., & Koch, M. (2011) · Laser & Photonics Reviews · doi:10.1002/lpor.201000011 · Cited by 2,091 · see citing works
Zeitler, J. A., Shen, Y., Baker, C., Taday, P. F., Pepper, M., & Rades, T. (2007) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.20789 · Cited by 208 · see citing works
Self-citationTHz-TDS Time-Trace Analysis for the Extraction of Material and Metamaterial Parameters
Peretti, R., Mitryukovskiy, S., Froberger, K., Mebarki, M. A., Eliet, S., Vanwolleghem, M., & Lampin, J.-F. (2019) · IEEE Transactions on Terahertz Science and Technology · doi:10.1109/tthz.2018.2889227 · Cited by 78 · see citing works
On the influence of water on THz vibrational spectral features of molecular crystals
Mitryukovskiy, S., Vanpoucke, D. E. P., Bai, Y., Hannotte, T., Lavancier, M., Hourlier, D., Roos, G., & Peretti, R. (2022) · Physical Chemistry Chemical Physics · doi:10.1039/d1cp03261e · Cited by 28 · see citing works
Peretti, R., Braud, F., Peytavit, E., Dubois, E., & Lampin, J.-F. (2018) · Photonics · doi:10.3390/photonics5020011 · Cited by 27 · see citing works
- Authors
- ZEITLER, J., KOGERMANN, K., RANTANEN, J., RADES, T., TADAY, P., PEPPER, M., AALTONEN, J., & STRACHAN, C.
- Affiliations
- TeraView (United Kingdom) (GB)
- University of Helsinki (FI)
- University of Cambridge (GB)
- Corresponding author
- STRACHAN, C
- Venue
- International Journal of Pharmaceutics
- Publisher
- Elsevier BV
- Published
- 2007-04-04
- Volume
- 334
- Issue
- 1-2
- Pages
- 78-84
- ISSN
- 0378-5173 (ISSN-L)
- OpenAlex
- W2073111850
- Cited by
- 150
- References
- 0
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 4 · 2022: 11 · 2021: 7 · 2020: 9 · 2019: 4 · 2018: 8 · 2017: 7 · 2016: 10 · 2015: 7 · 2014: 10 · 2013: 9 · 2012: 9
- FWCI
- 8.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Pharmaceutics (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Topics
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Terahertz technology and applications
- Physical Sciences › Materials Science › Materials Chemistry › Crystallization and Solubility Studies
- Physical Sciences › Materials Science › Materials Chemistry › Solid-state spectroscopy and crystallography
- Keywords
- dehydration, pharmaceutical polymorphs, lactose, carbamazepine, piroxicam, theophylline, theophylline monohydrate, anhydrous form, phase transitions, far-infrared spectroscopy, terahertz spectroscopy
- MeSH terms
- Carbamazepine, Chemistry, Pharmaceutical, Crystallization, Desiccation, Drug Stability, Pharmaceutical Preparations, Lactose, Piroxicam, Spectrum Analysis, Temperature, Theophylline, X-Ray Diffraction, Multivariate Analysis, Phase Transition
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