The DOI matches its Crossref record; 98 of the 98 references it cites were found in a registry or an index.
An Evidence-Based Update on Nonsteroidal Anti-Inflammatory Drugs
Open accessAbstract
Nonsteroidal anti-inflammatory drugs (NSAIDs), including both traditional nonselective NSAIDs and the selective cyclooxygenase (COX)-2 inhibitors, are widely used for their anti-inflammatory and analgesic effects. NSAIDs are a necessary choice in pain management because of the integrated role of the COX pathway in the generation of inflammation and in the biochemical recognition of pain. This group of drugs has recently come under scrutiny because of recent focus in the literature on the various adverse effects that can occur when applying NSAIDs. This review will provide an educational update on the current evidence of the efficacy and adverse effects of NSAIDs. It aims to answer the following questions: (1) are there clinically important differences in the efficacy and safety between the different NSAIDs, (2) if there are differences, which are the ones that are more effective and associated with fewer adverse effects, and (3) which are the effective therapeutic approaches that could reduce the adverse effects of NSAIDs. Finally, an algorithm is proposed which delineates a general decision-making tree to select the most appropriate analgesic for an individual patient based on the evidence reviewed.
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Citations
Cites
1 retracted
Analgesia and non-aspirin, non-steroidal anti-inflammatory drugs for osteoarthritis of the hip
Towheed, T., Mc, H., Shea, B., & Wells, G. A. (1997) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000517 · Cited by 37
RetractedBombardier, C., Laine, L., Reicin, A., Shapiro, D., Burgos-Vargas, R., Davis, B., Day, R., Ferraz, M. B., Hawkey, C. J., Hochberg, M. C., et al. (2000) · New England Journal of Medicine · doi:10.1056/nejm200011233432103 · Cited by 4,027
Silverstein, F. E., Faich, G., Goldstein, J. L., Simon, L. S., Pincus, T., Whelton, A., Makuch, R., Eisen, G., Agrawal, N. M., Stenson, W. F., et al. (2000) · JAMA · doi:10.1001/jama.284.10.1247 · Cited by 3,154
Cardiovascular Events Associated with Rofecoxib in a Colorectal Adenoma Chemoprevention Trial
Bresalier, R. S., Sandler, R. S., Quan, H., Bolognese, J. A., Oxenius, B., Horgan, K., Lines, C., Riddell, R., Morton, D., Lanas, A., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050493 · Cited by 2,519
Cyclooxygenase in biology and disease
DuBois, R. N., Abramson, S. B., Crofford, L., Gupta, R. A., Simon, L. S., van de Putte, L. B. A., & Lipsky, P. E. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.12.1063 · Cited by 2,506
Advances in Pain Research and Therapy
Wang, J. K. (1980) · Anesthesia & Analgesia · doi:10.1213/00000539-198002000-00022 · Cited by 2,255
Cardiovascular Risk Associated with Celecoxib in a Clinical Trial for Colorectal Adenoma Prevention
Solomon, S. D., McMurray, J. J. V., Pfeffer, M. A., Wittes, J., Fowler, R., Finn, P., Anderson, W. F., Zauber, A., Hawk, E., & Bertagnolli, M. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050405 · Cited by 2,052
Gastrointestinal Toxicity of Nonsteroidal Antiinflammatory Drugs
Wolfe, M. M., Lichtenstein, D. R., & Singh, G. (1999) · New England Journal of Medicine · doi:10.1056/nejm199906173402407 · Cited by 1,956
Larson, A. M., Polson, J., Fontana, R. J., Davern, T. J., Lalani, E., Hynan, L. S., Reisch, J. S., Schiødt, F. V., Ostapowicz, G., Shakil, A. O., et al. (2005) · Hepatology · doi:10.1002/hep.20948 · Cited by 1,926
The number needed to treat: a clinically useful measure of treatment effect
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Cited by
Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: A current perspective
Bindu, S., Mazumder, S., & Bandyopadhyay, U. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.114147 · Cited by 1,920
Ong, C. K. S., Seymour, R. A., Lirk, P., & Merry, A. F. (2010) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e3181cf9281 · Cited by 631
Self-citationDiclofenac: an update on its mechanism of action and safety profile
Gan, T. J. (2010) · Current Medical Research and Opinion · doi:10.1185/03007995.2010.486301 · Cited by 600
Efficacy of paracetamol for acute low-back pain: a double-blind, randomised controlled trial
Williams, C. M., Maher, C. G., Latimer, J., McLachlan, A. J., Hancock, M. J., Day, R. O., & Lin, C.-W. C. (2014) · The Lancet · doi:10.1016/s0140-6736(14)60805-9 · Cited by 325
Wang, R., Li, W., & Chen, Z. (2018) · Analytica Chimica Acta · doi:10.1016/j.aca.2018.02.024 · Cited by 132
Metadata
- Authors
- Ong, C. K. S., Lirk, P., Tan, C. H., & Seymour, R. A.
- Venue
- Clinical Medicine & Research
- Publisher
- Marshfield Clinic Research Institute
- Published
- 2007-03-01
- Volume
- 5
- Issue
- 1
- Pages
- 19-34
- ISSN
- 1539-4182 (ISSN-L)
- 1554-6179
- OpenAlex
- W2120857280
- Cited by
- 587
- References
- 98
- FWCI
- 7.64
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: An Evidence-Based Update on Nonsteroidal Anti-Inflammatory Drugs. https://app.cochat.ai/papers/10.3121/cmr.2007.698
- The paper
- Ong, C. K. S., Lirk, P., Tan, C. H., & Seymour, R. A. (2007). An Evidence-Based Update on Nonsteroidal Anti-Inflammatory Drugs. Clinical Medicine & Research. https://doi.org/10.3121/cmr.2007.698
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
