The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Association of Indicators of Stress, Sleep and Brain-Derived Neurotrophic Factor (BDNF) in a High-risk Sample of Young Adults with Previous Youth Residential Care
Open accessPreprint — published as 10.1038/s41598-023-47726-0 · Paper page
Abstract
BackgroundChildren in institutional care have a high risk to experience childhood adversities (CAs), with consequences for physical and mental well-being. The long-term effects of CAs on the brain, including consequences for neuronal plasticity and sleep, are poorly understood. This study examined the interplay between stress (including CAs), sleep, and brain-derived neurotrophic factor (BDNF), a prominent marker for neuronal plasticity. MethodParticipants (N=131, mean age = 26.33.4 years, 40 females) with residential youth-care history completed questionnaires measuring CAs (Childhood Trauma Questionnaire, CTQ), psychological well-being (World Health Organization-Five Well-Being Index, WHO-5), and sleep disturbances (Pittsburgh Sleep Quality Inventory, PSQI). Hair cortisol and serum BDNF concentration were measured using enzyme-linked immunosorbent assays. The analyses were conducted by using bootstrap regression models. ResultsThere was no association of stress parameters or sleep with BDNF concentration. However, we found a significant association of CAs and well-being with sleep disturbances. Last, we found an association between CAs and BDNF in sleep-healthy but not sleep-disturbed participants.ConclusionOur findings emphasize the importance of sleep quality in the association between stress and BDNF. Still, further studies are warranted using vulnerable groups at-risk to understand long-term effects on mental health and sleep.
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Colucci-D’Amato, L., Speranza, L., & Volpicelli, F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207777 · Cited by 991
Future Directions in Childhood Adversity and Youth Psychopathology
McLaughlin, K. A. (2016) · Journal of Clinical Child & Adolescent Psychology · doi:10.1080/15374416.2015.1110823 · Cited by 576
d’Huart, D., Steppan, M., Seker, S., Bürgin, D., Boonmann, C., Birkhölzer, M., Jenkel, N., Fegert, J. M., Schmid, M., & Schmeck, K. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.840678 · Cited by 35
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Metadata
- Authors
- Varghese, N., Bürgin, D., Boonmann, C., Stadler, C., Schmid, M., Eckert, A., & Unternaehrer, E.
- Affiliations
- University of Basel (CH)
- ORCID
- Venue
- Scientific Reports
- Publisher
- Center for Open Science
- Published
- 2023-04-13
- Volume
- 13
- Issue
- 1
- Pages
- 20524-20524
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC10665413
- OpenAlex
- W4388927221
- Cited by
- 11
- References
- 3
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 2
- FWCI
- 3.18
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Leiden Repository (Leiden University) (submittedVersion, cc-by)
- KOPS (University of Konstanz) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- OSF Preprints (OSF Preprints) (submittedVersion)
- OSF Preprints (OSF Preprints) (submittedVersion, cc-by)
- Funders
- Universität Konstanz
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- childhood adversity, institutionalized children, residential youth care, sleep disorders, brain-derived neurotrophic factor, hair cortisol, psychological well-being, stress, neuroplasticity, long-term effects of childhood trauma, young adults
- MeSH terms
- Adolescent, Adult, Brain, Female, Humans, Male, Sleep, Sleep Wake Disorders, Brain-Derived Neurotrophic Factor, Young Adult
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