Secondary Hyperparathyroidism: Pathophysiology and Treatment
Open accessAbstract
Secondary hyperparathyroidism is a frequently encountered problem in the management of patients with chronic kidney disease (CKD). Its pathophysiology is mainly due to hyperphosphatemia and vitamin D deficiency and resistance. This condition has a high impact on the mortality and morbidity of dialysis patients. Early diagnosis of secondary hyperparathyroidism is crucial in the management of patients with CKD. The treatment remains a challenge for patients and their clinicians. It should include a combination of dietary phosphorus restriction, phosphate binders, vitamin D analogues, and calcimimetics.
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Secondary hyperparathyroidism is characterised by elevated levels of parathyroid hormone caused by excessive activity and hyperplasia of the parathyroid glands.
“Secondary hyperparathyroidism is characterised by elevated levels of parathyroid hormone caused by excessive activity and hyperplasia of the parathyroid glands.302”
From A review of current trends with type 2 diabetes epidemiology, aetiology, pathogenesis, treatments and future perspectives (2021) · cites this paper as [302]
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- Authors
- Saliba, W., & El-Haddad, B.
- Affiliations
- University of Kansas (US)
- Venue
- The Journal of the American Board of Family Medicine
- Published
- 2009-09-01
- Volume
- 22
- Issue
- 5
- Pages
- 574-581
- ISSN
- 1557-2625 (ISSN-L)
- 1558-7118
- OpenAlex
- W2121733531
- Cited by
- 133
- References
- 31
- Citations by year
- 2026: 5 · 2025: 13 · 2024: 11 · 2023: 7 · 2022: 6 · 2021: 9 · 2020: 14 · 2019: 15 · 2018: 9 · 2017: 8 · 2016: 7 · 2015: 13 · 2014: 6 · 2013: 3 · 2012: 1
- FWCI
- 1.60
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of the American Board of Family Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
- Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Keywords
- secondary hyperparathyroidism, chronic kidney disease, hyperphosphatemia, vitamin D deficiency, vitamin D resistance, dialysis patients, dietary phosphorus restriction, phosphate binders, vitamin D analogs, calcimimetics, early diagnosis
- MeSH terms
- Humans, Hyperparathyroidism, Secondary, Kidney Failure, Chronic
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