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Cited by 60Iron Metabolism and DisordersTrace Elements in HealthFerroptosis and cancer prognosis

Iron regulation by hepatocytes and free radicals

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Takami, Taro, Sakaida, Isao·2011·Journal of Clinical Biochemistry and Nutrition
DOI 10.3164/jcbn.10-76PMC PMC3045680
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Abstract

Iron is an essential metallic microelement for life. However, iron overload is toxic. The liver serves an important role as a storehouse for iron in the body. About 20-25 mg of iron is required each day for hemoglobin synthesis. To maintain iron homeostasis, transferrin and transferrin receptors are primarily involved in the uptake of iron into hepatocytes, ferritin in its storage, and ferroportin in its export. Moreover, hepcidin controls ferroportin and plays a central role in the iron metabolism. Excess "free" reactive iron produces damaging free radicals via Fenton or Harber-Weiss reactions. Produced free radicals attack cellular proteins, lipids and nucleic acid. Several detoxification system and anti-oxidant defense mechanisms exist to prevent cellular damage by free radicals. Excessive free radicals can lead to hepatocellular damage, liver fibrosis, and hepatocarcinogenesis.

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  • NTBI is absorbed primarily by the liver via the SLC39A zinc transporter ZIP14.

    “NTBI is absorbed primarily by liver via SLC39A zinc transporter-ZIP14 (Takami and Sakaida, 2011).”

    From Iron, Oxidative Stress and Health (2012) · cites this paper as Takami and Sakaida, 2011

    The ‘Mechanisms of iron transport into hepatocytes’ section reports that ZIP14 is involved in NTBI uptake into hepatocytes, and reference 33 identifies it as Slc39a14. The passage also names DMT1 and does not establish that NTBI is taken up primarily by the liver or primarily via ZIP14. (LLM, conf=0.86)

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Cited by

Sorted by citations

  • Iron, Oxidative Stress and Health

    Udipi, S., Ghugre, P., & Gokhale, C. (2012) · Oxidative Stress - Molecular Mechanisms and Biological Effects · doi:10.5772/34975 · Cited by 17 · see citing works

    “Further, there are reports that hepatocytes can import iron by involving routes not involving TfRs. NTBI is absorbed primarily by liver via SLC39A zinc transporter–ZIP14 (Takami and Sakaida, 2011).”
    Background

Authors
Takami, T., & Sakaida, I.
Affiliations
  • Yamaguchi University Hospital (JP)
  • Yamaguchi University (JP)
Corresponding author
Sakaida, Isao
ORCID
Venue
Journal of Clinical Biochemistry and Nutrition
Publisher
The Society for Free Radical Research Japan
Published
2011
Volume
48
Issue
2
Pages
103-106
ISSN
  • 0912-0009 (ISSN-L)
  • 1880-5086
DOI
10.3164/jcbn.10-76
PMC
PMC3045680
OpenAlex
W1989020470
Cited by
60
References
12
Citations by year
2026: 2 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 7 · 2021: 3 · 2020: 6 · 2019: 3 · 2018: 5 · 2017: 1 · 2016: 6 · 2015: 6 · 2014: 4 · 2013: 5 · 2012: 5
FWCI
3.29
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Biochemistry and Nutrition (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
Japan Society for the Promotion of Science (21790667)
Topics
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
  • Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Ferroptosis and cancer prognosis
Keywords
iron homeostasis, hepatocytes, free radicals, iron overload, transferrin, transferrin receptor, ferritin, ferroportin, hepcidin, Fenton reaction, Haber-Weiss reaction, oxidative stress, antioxidant defense, liver fibrosis, hepatocarcinogenesis, iron metabolism

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