Cited by 416Neutrophil, Myeloperoxidase and Oxidative MechanismsRedox biology and oxidative stressAntioxidant Activity and Oxidative Stress

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Myeloperoxidase-derived oxidation: mechanisms of biological damage and its prevention

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Davies, Michael J.·2010·Journal of Clinical Biochemistry and Nutrition

DOI 10.3164/jcbn.11-006frPMC PMC3022070

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Abstract

There is considerable interest in the role that mammalian heme peroxidase enzymes, primarily myeloperoxidase, eosinophil peroxidase and lactoperoxidase, may play in a wide range of human pathologies. This has been sparked by rapid developments in our understanding of the basic biochemistry of these enzymes, a greater understanding of the basic chemistry and biochemistry of the oxidants formed by these species, the development of biomarkers that can be used damage induced by these oxidants in vivo, and the recent identification of a number of compounds that show promise as inhibitors of these enzymes. Such compounds offer the possibility of modulating damage in a number of human pathologies. This reviews recent developments in our understanding of the biochemistry of myeloperoxidase, the oxidants that this enzyme generates, and the use of inhibitors to inhibit such damage.

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Authors: Davies, M. J.
Affiliations: The University of Sydney (AU)
Corresponding author: Davies, Michael J.
ORCID: Davies, Michael J.
Venue: Journal of Clinical Biochemistry and Nutrition
Publisher: The Society for Free Radical Research Japan
Published: 2010
Volume: 48
Issue: 1
Pages: 8-19
ISSN: 0912-0009 (ISSN-L)
1880-5086
DOI: 10.3164/jcbn.11-006fr
PMC: PMC3022070
OpenAlex: W2028031080
Cited by: 412
References: 227
Citations by year: 2026: 18 · 2025: 15 · 2024: 31 · 2023: 30 · 2022: 34 · 2021: 40 · 2020: 41 · 2019: 37 · 2018: 27 · 2017: 29 · 2016: 23 · 2015: 21 · 2014: 19 · 2013: 16 · 2012: 24
FWCI: 6.45
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Biochemistry and Nutrition (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Fondation pour la Recherche Médicale
Medical Research Council
Australian Research Council (CE0561607, DP0988311)
National Health and Medical Research Council (570829)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords: myeloperoxidase, heme peroxidase, eosinophil peroxidase, lactoperoxidase, oxidative damage, oxidative damage biomarkers, enzyme inhibitors

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Myeloperoxidase-derived oxidation: mechanisms of biological damage and its prevention

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