Fat-soluble vitamins and plasma and erythrocyte membrane fatty acids in chylothorax pediatric patients receiving a medium-chain triglyceride-rich diet
Open accessAbstract
Post-operative chylothorax can be cured by a medium-chain triglyceride (MCT)-rich diet. However, there is concern that an MCT-rich diet results in clinical and biochemical deficiencies in fat-soluble vitamins and fatty acids. We compared fat-soluble vitamins status and fatty acids status before and after administration of an MCT-rich diet. Nine children with congenital heart disease developed chylothorax after cardiac surgery. Blood samples were drawn from each subject twice, first prior to administration of an MCT-rich diet and secondly when the chylothorax was clinically cured and the MCT diet discontinued. Both blood samples were analyzed for retinol and 25-hydroxy vitamin D concentrations, the ratio of α-tocopherol to total lipids (α-TE/TL), coagulogram, and the fatty acid composition in plasma and erythrocyte membrane phospholipids. In spite of a decrease in the α-TE/TL ratio (3.78 ± 0.89 vs 2.36 ± 0.44 mg/g, p<0.05), this decrease did not reach the deficiency cut-off level. Linoleic acid in both plasma and erythrocyte membrane lipids decreased significantly (25.25 ± 8.06 vs 14.25 ± 2.88%, and 11.19 ± 2.15 vs 6.89 ± 2.45%, respectively). Administration of an MCT-rich diet for treatment of postoperative chylothorax caused a reduction in vitamin E status and linoleic acid, but without any symptoms of deficiency.
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The safety of long-term use of high doses of MCT oil is not established.
“The safety of long-term use of high doses of MCT oil is not established.31,32”
From Familial chylomicronemia syndrome: Bringing to life dietary recommendations throughout the life span (2018) · cites this paper as [32]
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Familial chylomicronemia syndrome: Bringing to life dietary recommendations throughout the life span
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- Authors
- Densupsoontorn, N., Jirapinyo, P., Tirapongporn, H., Wongarn, R., Chotipanang, K., Phuangphan, P., & Chongviriyaphan, N.
- Affiliations
- Siriraj Hospital (TH)
- Mahidol University (TH)
- Corresponding author
- Densupsoontorn, Narumon
- Venue
- Journal of Clinical Biochemistry and Nutrition
- Published
- 2014
- Volume
- 55
- Issue
- 3
- Pages
- 174-177
- ISSN
- 0912-0009 (ISSN-L)
- 1880-5086
- PMC
- PMC4227826
- OpenAlex
- W2021511223
- Cited by
- 12
- References
- 15
- Citations by year
- 2024: 1 · 2023: 3 · 2021: 1 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 1
- FWCI
- 1.32
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Journal of Clinical Biochemistry and Nutrition (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Mahidol University
- Faculty of Medicine Siriraj Hospital, Mahidol University
- Topics
- Health Sciences › Medicine › Surgery › Lymphatic Disorders and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Keywords
- chylothorax, medium-chain triglyceride diet, fat-soluble vitamins, vitamin E status, vitamin D, retinol, linoleic acid, erythrocyte membrane fatty acids, plasma fatty acids, congenital heart disease, postoperative complications, children
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