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Cited by 14Osteoarthritis Treatment and MechanismsPharmacological Effects of Medicinal PlantsNatural product bioactivities and synthesis

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Maslinic acid improves quality of life by alleviating joint knee pain in the elderly: results from a community-based pilot study

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Fukumitsu, Satoshi, Kinoshita, Tetsu, Villareal, Myra O., Aida, Kazuhiko, Hino, Akihiro, Isoda, Hiroko·2017·Journal of Clinical Biochemistry and Nutrition
DOI 10.3164/jcbn.16-119PMC PMC5525013
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Abstract

Chronic knee joint pain is common in the elderly and associated with poor quality of life. This study, an open-label clinical trial, aimed to examine how the intake on a daily basis of maslinic acid-containing product (30 mg maslinic acid) on 29 elderly residents (mean 70.7 ± 10.1 years) of Nakajima Island, Ehime, Japan. Study participants consumed 10 g jelly containing maslinic acid daily for 16 weeks and at 0 (baseline), 4, 8, 12 and 16 weeks, assessed for health-related quality of life (Short Form-8) and knee pain score (Japanese Knee Osteoarthritis Measure). After 16 weeks, the physical quality of life, more specifically, the level of Bodily Pain and Physical Component Summary, but not mental quality of life, was significantly improved by maslinic acid intake. Furthermore, maslinic acid intake significantly decreased the Japanese Knee Osteoarthritis Measure at week 8 and tended to decrease Visual Analogue Scale score at weeks 4 and 16. These results suggest that consumption of maslinic acid has a protective effect against chronic knee pain in elderly residents in a community where knee pain causes high quality of life burden.

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Crossref · 10.3164/jcbn.16-119

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Figures

Fig. 1 Chemical structure of maslinic acid (2α,3β-dihydroxyolean-12-en-28-oic acid).
Fig. 1 Chemical structure of maslinic acid (2α,3β-dihydroxyolean-12-en-28-oic acid).CC BY · PubMed Central
Fig. 2 Study design for the 16-week study. Arrows indicate visits to the community center, assessment of visual analogue scale and Short Form 8 at baseline and after 4, 8, 12 and 16 weeks. Assessment of Japanese Knee Osteoarthritis Measure at baseline and after 8 and 16 weeks.
Fig. 2 Study design for the 16-week study. Arrows indicate visits to the community center, assessment of visual analogue scale and Short Form 8 at baseline and after 4, 8, 12 and 16 weeks. Assessment of Japanese Knee Osteoarthritis Measure at baseline and after 8 and 16 weeks.CC BY · PubMed Central
Fig. 3 Visual analogue scale joint pain scores at baseline and after 4, 8, 12 and 16 weeks of daily ingestion of maslinic acid jelly. The values in the graph represent mean ± SD. †p<0.1 vs baseline.
Fig. 3 Visual analogue scale joint pain scores at baseline and after 4, 8, 12 and 16 weeks of daily ingestion of maslinic acid jelly. The values in the graph represent mean ± SD. †p<0.1 vs baseline.CC BY · PubMed Central
Fig. 4 Japanese Knee Osteoarthritis Measure score at baseline, 8 and 16 weeks of daily ingestion of maslinic acid jelly. The values in the graph represent mean ± SD. *p<0.01 vs baseline.
Fig. 4 Japanese Knee Osteoarthritis Measure score at baseline, 8 and 16 weeks of daily ingestion of maslinic acid jelly. The values in the graph represent mean ± SD. *p<0.01 vs baseline.CC BY · PubMed Central
Fig. 5 Short Form 8 scores at baseline, 4, 8, 12 and 16 weeks of daily ingestion of maslinic acid jelly. The values in the graph represent mean ± SD. †p<0.1, *p<0.05, **p<0.01 vs baseline. Physical function (PF), role physical (RP), bodily pain (BP), general health (GH), vitality (VT), social functioning (SF), role emotional (RE), mental health (MH).
Fig. 5 Short Form 8 scores at baseline, 4, 8, 12 and 16 weeks of daily ingestion of maslinic acid jelly. The values in the graph represent mean ± SD. †p<0.1, *p<0.05, **p<0.01 vs baseline. Physical function (PF), role physical (RP), bodily pain (BP), general health (GH), vitality (VT), social functioning (SF), role emotional (RE), mental health (MH).CC BY · PubMed Central
Fig. 6 Average Short Form 8 scores at baseline and 16 weeks on the effect of maslinic acid intake on the quality of life (QOL) parameters: physical function (PF), role physical (RP), bodily pain (BP), general health (GH), vitality (VT), social functioning (SF), role emotional (RE), mental health (MH). †p<0.1, *p<0.05 vs baseline.
Fig. 6 Average Short Form 8 scores at baseline and 16 weeks on the effect of maslinic acid intake on the quality of life (QOL) parameters: physical function (PF), role physical (RP), bodily pain (BP), general health (GH), vitality (VT), social functioning (SF), role emotional (RE), mental health (MH). †p<0.1, *p<0.05 vs baseline.CC BY · PubMed Central
Fig. 7 Short Form 8 summary scores at baseline, 4, 8, 12 and 16 week of daily ingestion of maslinic acid jelly. The values in the graph represent mean ± SD. *p<0.01 vs baseline. PCS, physical component summary; MCS, mental component summary.
Fig. 7 Short Form 8 summary scores at baseline, 4, 8, 12 and 16 week of daily ingestion of maslinic acid jelly. The values in the graph represent mean ± SD. *p<0.01 vs baseline. PCS, physical component summary; MCS, mental component summary.CC BY · PubMed Central

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Metadata

Authors
Fukumitsu, S., Kinoshita, T., Villareal, M. O., Aida, K., Hino, A., & Isoda, H.
Affiliations
  • University of Tsukuba (JP)
  • Institute of Community Life Sciences Co., Ltd., Social Epidemiology Institute
  • Nippon Flour Mills (Japan) (JP)
Corresponding author
Fukumitsu, Satoshi
ORCID
Venue
Journal of Clinical Biochemistry and Nutrition
Publisher
The Society for Free Radical Research Japan
Published
2017
Volume
61
Issue
1
Pages
67-73
ISSN
  • 0912-0009 (ISSN-L)
  • 1880-5086
DOI
10.3164/jcbn.16-119
PMC
PMC5525013
OpenAlex
W2615274880
Cited by
14
References
20
Citations by year
2025: 2 · 2023: 3 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 1
FWCI
0.96
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Biochemistry and Nutrition (publishedVersion)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Institutional Repositories DataBase (IRDB) (publishedVersion)
  • Terrestrial Environment Research Center (University of Tsukuba) (submittedVersion)
Topics
  • Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
  • Health Sciences › Medicine › Pharmacology (medical) › Pharmacological Effects of Medicinal Plants
  • Physical Sciences › Chemistry › Organic Chemistry › Natural product bioactivities and synthesis
Keywords
maslinic acid, knee pain, knee osteoarthritis, older adults, health-related quality of life, dietary supplementation, community-based intervention

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