The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Glycosylation and Placental Transport of Immunoglobulin G.
Open accessAbstract
In order to investigate the relationship between the changes in glycosylation and the placental materno-fetal transport of Immunoglobulin G (IgG), glycosylation profiles of IgG from healthy pregnant women and their umbilical cords at delivery were compared by use of a recently established high-performance liquid chromatography (HPLC) method. From the results of neutral oligosaccharide analysis, the digalactosyl IgG glycoform (G2) was markedly increased in pregnant women as compared with that in age-matched controls. Furthermore, the quantity of the digalactosyl glycoform in the umbilical cord was found to be higher than that in the mother. These findings demonstrate the existence of a placental selective transport with a preference for a digalactosyl oligosaccharide-linked IgG molecule. Concerning IgG sialo-oligosaccharides, however, no selective transport was observed between mother and umbilical cord. The mechanism and clinical importance of greater galactosylation in IgG still remain unclear, but we suggest that the relationship between changes in IgG galactosylation and the placental selective transport deserves further attention.
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“studies in the 1990s, which demonstrated reduced concentrations of non-glycosylated IgG and higher concentrations of galactosylated IgG in newborn infants (85, 86).”
From Factors Affecting the FcRn-Mediated Transplacental Transfer of Antibodies and Implications for Vaccination in Pregnancy (2017) · cites this paper as [86]
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Citations
Cites
Elevation of Cord over Maternal IgG Immunoglobulin: Evidence for an Active Placental IgG Transport
KOHLER, P. F., & FARR, R. S. (1966) · Nature · doi:10.1038/2101070a0 · Cited by 325
Research works printed but not linked: 1
- Yamada, E., Tsukamoto, Y., Sasaki, R., Yagyu, K., and Takahashi, N. (1996): Structural changes of immunoglobulin G oligosaccharides with age in healthy human serum. Glyco- conjugate J (in press), 10.
Cited by
Wilcox, C. R., Holder, B., & Jones, C. E. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01294 · Cited by 200
“Supportive evidence for the hypothesis of preferential transport of glycosylated IgG comes from studies in the 1990s, which demonstrated reduced concentrations of nonglycosylated IgG and higher concentrations of galactosylated IgG in newborn infants (85, 86).”
Metadata
- Authors
- KIBE, T., FUJIMOTO, S., ISHIDA, C., TOGARI, H., WADA, Y., OKADA, S., NAKAGAWA, H., TSUKAMOTO, Y., & TAKAHASHI, N.
- Affiliations
- Nagoya City University (JP)
- Venue
- Journal of Clinical Biochemistry and Nutrition
- Published
- 1996
- Volume
- 21
- Issue
- 1
- Pages
- 57-63
- ISSN
- 0912-0009 (ISSN-L)
- 1880-5086
- OpenAlex
- W2012222959
- Cited by
- 63
- References
- 1
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 5 · 2020: 2 · 2019: 3 · 2017: 2 · 2016: 4 · 2015: 2 · 2014: 5 · 2013: 4 · 2012: 3
- FWCI
- 0.38
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Biochemistry and Nutrition (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
- Health Sciences › Medicine › Hematology › Blood groups and transfusion
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Keywords
- IgG, IgG glycosylation, placental transport, galactosylation, umbilical cord, oligosaccharide analysis, pregnancy
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- CoChat. (2026). Citation check: Glycosylation and Placental Transport of Immunoglobulin G. https://app.cochat.ai/papers/10.3164/jcbn.21.57
- The paper
- KIBE, T., FUJIMOTO, S., ISHIDA, C., TOGARI, H., WADA, Y., OKADA, S., NAKAGAWA, H., TSUKAMOTO, Y., & TAKAHASHI, N. (1996). Glycosylation and Placental Transport of Immunoglobulin G. Journal of Clinical Biochemistry and Nutrition. https://doi.org/10.3164/jcbn.21.57
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
