The DOI matches its Crossref record; 35 of the 36 references it cites were found in a registry or an index.
Effects of feeding a calf starter on molecular adaptations in the ruminal epithelium and liver of Holstein dairy calves
Open accessAbstract
The objective of this study was to elucidate the effect of feeding a calf starter on the volatile fatty acid (VFA) profile in the rumen and on expression of genes involved in epithelial intracellular pH regulation, butyrate metabolism, and hepatic urea cycle during the weaning transition. Twenty Holstein bull calves were fed either milk replacer and hay (MR) or milk replacer, hay, and a commercial texturized calf starter (MR+S) in a randomized complete block design. All calves were fed 750 g/d of milk replacer as the basal diet. Calves on the MR+S treatment were also fed starter ad libitum, and the energy intake of calves within blocks was maintained by supplementing the MR group with extra milk replacer that was equivalent to the energy intake from calf starter. Calves were killed 3 d after they consumed 680 g/d of calf starter for 3 consecutive days. Calves fed MR+S had higher VFA concentrations in the rumen (99.1±8.1 vs. 64.6±8.6 mM) and a higher molar proportion of butyrate (15.6±1.7 vs. 7.9±1.9%) than calves fed MR. Relative abundance of mRNA for monocarboxylate transporter isoform 1 was higher (1.45 vs. 0.53), and that of Na(+)/H(+) exchanger isoform 3 (0.37 vs. 0.82) and 3-hydroxy-3-methylglutaryl synthase isoform 1 (0.40 vs. 0.94) lower for the MR+S treatment compared with the MR treatment. In the liver, relative mRNA abundances of argininosuccinate synthetase isoform 1 (2.67 vs. 1.56), argininosuccinate lyase (1.44 vs. 0.99), and arginase isoform 1 (3.21 vs. 1.74) we…
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“proteins involved in VFA absorption and intracellular pH regulation, including 3-hydroxy-3-methylglutaryl-CoA synthase (HMGCS), 3-hydroxy-3-methylglutaryl-CoA lyase (HMGCL), vacuolar H+ ATPase subunit B (ATPeV1B), and β-hydroxybutyrate dehydrogenase (BDH) [26–28], were expressed at a higher level in the rumen than in the cecum (p < 0.001, Fig. 1I).”
From Reductive acetogenesis is a dominant process in the ruminant hindgut (2025) · cites this paper as [27]
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Yeoman, C. J., Ishaq, S. L., Bichi, E., Olivo, S. K., Lowe, J., & Aldridge, B. M. (2018) · Scientific Reports · doi:10.1038/s41598-018-21440-8 · Cited by 168
Malhi, M., Gui, H., Yao, L., Aschenbach, J. R., Gäbel, G., & Shen, Z. (2013) · Journal of Dairy Science · doi:10.3168/jds.2013-6700 · Cited by 162
Metadata
- Authors
- Laarman, A. H., Ruiz-Sanchez, A. L., Sugino, T., Guan, L. L., & Oba, M.
- Affiliations
- University of Alberta (CA)
- Hiroshima University (JP)
- Corresponding author
- Oba, M.
- Venue
- Journal of Dairy Science
- Publisher
- American Dairy Science Association
- Published
- 2012-05
- Volume
- 95
- Issue
- 5
- Pages
- 2585-2594
- ISSN
- 0022-0302 (ISSN-L)
- OpenAlex
- W1975203172
- Cited by
- 101
- References
- 36
- Citations by year
- 2026: 9 · 2025: 6 · 2024: 8 · 2023: 7 · 2022: 7 · 2021: 5 · 2020: 11 · 2019: 9 · 2018: 9 · 2017: 5 · 2016: 7 · 2015: 8 · 2014: 4 · 2013: 4 · 2012: 2
- FWCI
- 11.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Dairy Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Natural Sciences and Engineering Research Council
- Japanese Federation of Dairy Cooperative Associations
- Canadian Dairy Commission
- Topics
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Ruminant Nutrition and Digestive Physiology
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal health and immunology
- Keywords
- calf starter, weaning transition, rumen volatile fatty acids, butyrate metabolism, rumen epithelium, intracellular pH regulation, MCT1, Na+/H+ exchanger 3, HMG-CoA synthase, argininosuccinate synthetase, arginase, cholesterol biosynthesis, gene expression, Holstein bull calves, milk replacer
- MeSH terms
- Animals, Animal Feed, Animals, Newborn, Blood Glucose, Energy Intake, Cattle, Diet, Epithelium, Fatty Acids, Volatile, Insulin, Liver, Rumen, Gene Expression, 3-Hydroxybutyric Acid, Real-Time Polymerase Chain Reaction
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