Effect of Coagulants, Somatic Cell Enzymes, and Extracellular Bacterial Enzymes on Plasminogen Activation
Open accessAbstract
Any factor that converts plasminogen (inactive form of the proteolytic enzyme plasmin) to plasmin in milk may have a negative impact on milk protein functionality.The effect of milk coagulants (calf rennet and proteases from Mucor miehei, Enabthia parasitica, Mucor pusillus), leukocytes from bovine blood, somatic cells from high SCC bovine milk, and extracellular bacterial enzymes from psychrotrophic bacteria and mastitis pathogens on the conversion of plasminogen to plasmin was determined.Constituents of somatic cells isolated from high SCC bovine milk were able to convert plasminogen to plasmin.This plasminogen activator was inactivated by heating milk to 63'C for 30 min.Leukocytes from bovine blood, milk coagulants, and extracellular bacterial enzymes were not able to convert plasminogen to plasmin.Therefore, a source of plasminogen activator in milk is somatic cells.Plasminogen present in milk could be converted to plasmin in the udder before millcing or during milk storage after milking, resulting in increased proteolysis of casein.Proteolytic damage to casein influences cheese yield, milk protein functionality, and dairy product quality.
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Somatic cell proteinases are capable of activating plasminogen.
“Somatic cell proteinases are capable of activating plasminogen [141]”
From Biochemical pathways for the production of flavour compounds in cheeses during ripening: A review (2000) · cites this paper as [141]
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- Authors
- Verdi, R. J., & Barbano, D. M.
- Affiliations
- Cornell University (US)
- ORCID
- Barbano, David M.
- Venue
- Journal of Dairy Science
- Publisher
- American Dairy Science Association
- Published
- 1991-03
- Volume
- 74
- Issue
- 3
- Pages
- 772-782
- ISSN
- 0022-0302 (ISSN-L)
- OpenAlex
- W2062989498
- Cited by
- 46
- References
- 34
- Citations by year
- 2022: 1 · 2019: 2 · 2013: 2 · 2012: 2
- FWCI
- 3.00
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Dairy Science (publishedVersion, cc-by-nc-nd)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Milk Quality and Mastitis in Dairy Cows
- Life Sciences › Agricultural and Biological Sciences › Food Science › Proteins in Food Systems
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Enzyme Production and Characterization
- Keywords
- plasminogen activation, plasminogen activator, somatic cells, milk coagulants, calf rennet, Mucor pusillus, bovine leukocytes, psychrotrophic bacteria, mastitis pathogens, casein hydrolysis, cheese yield, thermal inactivation
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