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Nitric Oxide Production During Endotoxin-Induced Mastitis in the Cow
Open accessAbstract
Nitric oxide production was measured during endotoxin-induced mastitis. One hour after morning milking, the right hind quarters of 15 cows were infused with saline containing Escherichia coli endotoxin. Left hind control quarters were infused with saline only. At varying intervals before and after infusion, diagnostic markers of mastitis were recorded and nitric oxide production was evaluated by measuring nitrite plus nitrate levels in milk. In endotoxin-infused quarters, a significant increase in nitrite plus nitrate concentrations was observed 3 h postinfusion; concentrations decreased to preinfusion levels within 48 h. This change indicates that significant amounts of nitric oxide are released during endotoxin-induced mastitis. At 3 different time points, somatic cells were harvested from milk samples, plated, and maintained in culture for 24 h. The concentration of nitrite plus nitrate in medium from cells harvested 12 h postinfusion was increased, suggesting that nitric oxide is released, at least in part, by milk somatic cells. In a second set of experiments, we evaluated nitric oxide production when animals were infused with endotoxin and aminoguanidine, a specific inhibitor of the inducible form of nitric oxide synthase. In cows treated with aminoguanidine, the increase in nitrite plus nitrate observed after endotoxin infusion was prevented. These results suggest that nitric oxide production during endotoxin-induced mastitis resulted from the activity of the inducible form of nitric oxide synthase. They also support a possible involvement for nitric oxide in the inflammatory reaction observed during mastitis.
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“Decreased milk production during clinical coliform mastitis results both directly and indirectly from the local and systemic effects of endotoxin [3, 21, 22].”
From Coliform mastitis (2003) · cites this paper as [3]
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“Damage to the host is mediated by the release of endotoxin.”
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Metadata
- Authors
- Bouchard, L., Blais, S., Desrosiers, C., Zhao, X., & Lacasse, P.
- Affiliations
- Agriculture and Agri-Food Canada (CA)
- Sherbrooke Research and Development Centre (CA)
- Venue
- Journal of Dairy Science
- Publisher
- American Dairy Science Association
- Published
- 1999-12
- Volume
- 82
- Issue
- 12
- Pages
- 2574-2581
- ISSN
- 0022-0302 (ISSN-L)
- OpenAlex
- W1978572081
- Cited by
- 108
- References
- 36
- Citations by year
- 2024: 3 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 4 · 2019: 2 · 2018: 4 · 2017: 10 · 2016: 7 · 2015: 5 · 2014: 6 · 2013: 8 · 2012: 7
- FWCI
- 5.61
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Dairy Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Dairy Farmers of Canada
- Novalait
- Topics
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Milk Quality and Mastitis in Dairy Cows
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal health and immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- nitric oxide, bovine mastitis, endotoxin, Escherichia coli endotoxin, milk, milk somatic cells, inducible nitric oxide synthase, aminoguanidine, inflammation, dairy cattle
- MeSH terms
- Animals, Cattle, Cells, Cultured, Endotoxins, Enzyme Inhibitors, Escherichia coli, Female, Guanidines, Kinetics, Mastitis, Bovine, Milk, Nitrates, Nitric Oxide, Nitrites, Nitric Oxide Synthase, Nitric Oxide Synthase Type II
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