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Cited by 16Traumatic Brain Injury ResearchPituitary Gland Disorders and TreatmentsTraumatic Brain Injury and Neurovascular Disturbances

The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.

Decreased apparent diffusion coefficient in the pituitary and correlation with hypopituitarism in patients with traumatic brain injury

Zheng, Ping, He, Bin, Guo, Yijun, Zeng, Jingsong, Tong, Wusong·2015·Journal of Neurosurgery
DOI 10.3171/2014.12.jns132308
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Abstract

OBJECT: The relationship between microstructural abnormality in patients with traumatic brain injury (TBI) and hormone-secreting status remains unknown. In this study, the authors aimed to identify the role of the apparent diffusion coefficient (ADC) using a diffusion-weighted imaging (DWI) technique and to evaluate the association of such changes with hypopituitarism in patients with TBI. METHODS: Diffusion-weighted images were obtained in 164 consecutive patients with TBI within 2 weeks after injury to generate the pituitary ADC as a measure of microstructural change. Patients with TBI were further grouped into those with and those without hypopituitarism based on the secretion status of pituitary hormones at 6 months postinjury. Thirty healthy individuals were enrolled in the study and underwent MRI examinations for comparison. Mean ADC values were compared between this control group, the patients with TBI and hypopituitarism, and the patients with TBI without hypopituitarism; correlational studies were also performed. Neurological outcome was assessed with the Glasgow Outcome Scale (GOS) for all TBI patients 6 months postinjury. RESULTS: In the TBI group, 84 patients had hypopituitarism and 80 had normal pituitary function. The pituitary ADC in TBI patients was significantly less than that in controls (1.83 ± 0.16 vs 4.13 ± 0.33, p < 0.01). Furthermore, the mean ADC was much lower in TBI patients with hypopituitarism than in those without pituitary dysfunction (1.32 ± 0.09 vs 2.28 ± 0.17, p < 0.05). There was also a significant difference in ADC values between patients with hyperprolactinemia and those with normal prolactin levels (p < 0.05). Additionally, the receiver operating characteristic curve analysis showed that the pituitary ADC could predict hypopituitarism with a sensitivity of 90.0% and a specificity of 90.1% at the level of 1.720 (ADC value). Finally, the ADC value was positively correlated with neurological outcome at 6 months following TBI (r = 0.602, p < 0.05). CONCLUSIONS: Use of DWI demonstrated that the pituitary ADC is correlated with hormone-secreting status in TBI patients. The authors suggest that pituitary ADC may be a useful biomarker to predict pituitary function in patients with TBI.

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Crossref · 10.3171/2014.12.jns132308

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Metadata

Authors
Zheng, P., He, B., Guo, Y., Zeng, J., & Tong, W.
Affiliations
Pudong New Area People's Hospital (CN)
ORCID
Venue
Journal of Neurosurgery
Publisher
Journal of Neurosurgery Publishing Group (JNSPG)
Published
2015-07
Volume
123
Issue
1
Pages
75-80
ISSN
  • 0022-3085 (ISSN-L)
  • 1933-0693
DOI
10.3171/2014.12.jns132308
OpenAlex
W2003802121
Semantic Scholar
30e27b84635fc9e46e6810d8a79081d471a1ee0f
Cited by
16
References
21
Citations by year
2026: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 1 · 2017: 3 · 2016: 2 · 2015: 1
FWCI
1.43
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of neurosurgery (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
  • Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Keywords
traumatic brain injury, hypopituitarism, pituitary gland, apparent diffusion coefficient, diffusion-weighted imaging, microstructural damage, hyperprolactinemia, pituitary hormone secretion, neurological outcome, prognosis, MRI biomarkers, Glasgow Outcome Scale, pituitary MRI, prognostic value, ROC curve
MeSH terms
Adolescent, Adult, Aged, Brain, Brain Injuries, Female, Humans, Hypopituitarism, Male, Middle Aged, Pituitary Gland, Pituitary Hormones, Prolactin, Prospective Studies, Sensitivity and Specificity, Case-Control Studies, Diffusion Magnetic Resonance Imaging, Young Adult

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