Language supplementary motor area syndrome correlated with dynamic changes in perioperative task-based functional MRI activations: case report
Open accessAbstract
Supplementary motor area (SMA) syndrome is well known; however, the mechanism underlying recovery from language SMA syndrome is unclear. Herein the authors report the case of a right-handed woman with speech aphasia following resection of an oligodendroglioma located in the anterior aspect of the left superior frontal gyrus. The patient exhibited language SMA syndrome, and functional MRI (fMRI) findings 12 days postoperatively demonstrated a complete shift of blood oxygen level–dependent (BOLD) activation to the contralateral right language SMA/pre-SMA as well as coequal activation and an increased volume of activation in the left Broca’s area and the right Broca’s homolog. The authors provide, to the best of their knowledge, the first description of dynamic changes in task-based hemispheric language BOLD fMRI activations across the preoperative, immediate postoperative, and more distant postoperative settings associated with the development and subsequent complete resolution of the clinical language SMA syndrome.
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A recent non-peer-reviewed preprint found that neural populations in the SMA are among the earliest predictors of speech onset and may remain strongly activated in imagined and attempted speech.
“A recent non-peer-reviewed preprint found that neural populations in the SMA are among the earliest predictors of speech onset and may remain strongly activated in imagined and attempted speech170.”
From The speech neuroprosthesis (2024) · cites this paper as [170]
The fMRI Paradigms section describes covert word-generation tasks, and the Figure 2 caption reports pre-SMA activation during those tasks. But this Journal of Neurosurgery case report does not establish that SMA neural populations are among the earliest predictors of speech onset or that they remain strongly activated during attempted speech; it is also not a non-peer-reviewed preprint. (LLM, conf=0.84)
Experimental — accuracy not yet measuredThe SMA is an important region in the speech production network and is involved in speech initiation.
“The supplementary motor area (SMA) is another important region in the speech production network165,169 that is involved in speech initiation170.”
From The speech neuroprosthesis (2024) · cites this paper as [170]
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“The supplementary motor area (SMA) is another important region in the speech production network 165,169 that is involved in speech initiation 170 .”
- Authors
- Quirarte, J. A., Kumar, V. A., Liu, H.-L., Noll, K. R., Wefel, J. S., & Lang, F. F.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- Neuroradiology, and
- Corresponding author
- Kumar, Vinodh A.
- Venue
- Journal of Neurosurgery
- Published
- 2021-06
- Volume
- 134
- Issue
- 6
- Pages
- 1738-1742
- ISSN
- 0022-3085 (ISSN-L)
- 1933-0693
- OpenAlex
- W3033821311
- Cited by
- 15
- References
- 20
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 5 · 2022: 2 · 2021: 3 · 2012: 1
- FWCI
- 1.35
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of neurosurgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hemispheric Asymmetry in Neuroscience
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Neurological and metabolic disorders
- Keywords
- oligodendroglioma, pre-supplementary motor area, Broca's area, postoperative recovery, task-based fMRI, BOLD activation
- MeSH terms
- Aphasia, Broca, Brain Neoplasms, Female, Glioma, Humans, Language, Magnetic Resonance Imaging, Motor Cortex, Postoperative Care, Psychomotor Performance, Perioperative Care, Young Adult, Broca Area
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