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Methylprednisolone and neurological function 1 year after spinal cord injury: Results of the National Acute Spinal Cord Injury Study
Abstract
✓ A multi-center double-blind randomized clinical trial was conducted by the National Acute Spinal Cord Injury Study Group to examine the efficacy of high-dose methylprednisolone (1000-mg bolus and 1000 mg daily thereafter for 10 days) compared with that of a standard dose (100-mg bolus and 100 mg daily for 10 days). No significant difference was observed in neurological recovery of motor function, pinprick response, or touch sensation 1 year after injury between the two treatment groups, after adjustment for other potentially confounding factors. Analyses that specifically took into account the patients' total steroid dose and relative weight confirmed the lack of a steroid treatment effect. The case fatality rate was 10.7% during the 1st year after injury, and this was not associated with the steroid treatment protocol or the patient's gender. Deaths did occur significantly more frequently among patients who were completely (15.3%) and partially (8.6%) plegic than among those who were paretic (2.5%, p = 0.0005), and among patients aged 50 years or older (38.6%, p = 0.0001).
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Citations
Cited by
Central nervous system trauma and stroke
Hall, E. D., & Braughler, J. M. (1989) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(89)90057-9 · Cited by 586
Liu, W.-Z., Ma, Z.-J., Li, J.-R., & Kang, X.-W. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02153-8 · Cited by 252
Datto, J. P., Bastidas, J. C., Miller, N. L., Shah, A. K., Arheart, K. L., Marcillo, A. E., Dietrich, W. D., & Pearse, D. D. (2015) · Journal of Neurotrauma · doi:10.1089/neu.2014.3702 · Cited by 96
Dulin, J. N., Moore, M. L., & Grill, R. J. (2013) · Journal of Neurotrauma · doi:10.1089/neu.2012.2587 · Cited by 24
Metadata
- Authors
- Bracken, M. B., Shepard, M. J., Hellenbrand, K. G., Collins, W. F., Leo, L. S., Freeman, D. F., Wagner, F. C., Flamm, E. S., Eisenberg, H. M., Goodman, J. H., Perot, P. L., Green, B. A., Grossman, R. G., Meagher, J. N., Young, W., Fischer, B., Clifton, G. L., Hunt, W. E., & Rifkinson, N.
- Venue
- Journal of Neurosurgery
- Published
- 1985-11
- Volume
- 63
- Issue
- 5
- Pages
- 704-713
- ISSN
- 0022-3085 (ISSN-L)
- OpenAlex
- W1510677902
- Cited by
- 350
- References
- 0
- FWCI
- 3.72
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Methylprednisolone and neurological function 1 year after spinal cord injury: Results of the National Acute Spinal Cord Injury Study. https://app.cochat.ai/papers/10.3171/jns.1985.63.5.0704
- The paper
- Bracken, M. B., Shepard, M. J., Hellenbrand, K. G., Collins, W. F., Leo, L. S., Freeman, D. F., Wagner, F. C., Flamm, E. S., Eisenberg, H. M., Goodman, J. H., Perot, P. L., Green, B. A., Grossman, R. G., Meagher, J. N., Young, W., Fischer, B., Clifton, G. L., Hunt, W. E., & Rifkinson, N. (1985). Methylprednisolone and neurological function 1 year after spinal cord injury: Results of the National Acute Spinal Cord Injury Study. Journal of Neurosurgery. https://doi.org/10.3171/jns.1985.63.5.0704
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
